Tchem NUCB1 Nucleobindin-1

Protein Summary

Description

Major calcium-binding protein of the Golgi. May have a role in calcium homeostasis (By similarity). This gene encodes a member of a small calcium-binding EF-hand protein family. The encoded protein is thought to have a key role in Golgi calcium homeostasis and Ca(2+)-regulated signal transduction events. [provided by RefSeq, Jun 2010]

Uniprot Accession IDs

• Q02818
• B2RD64
• Q15838
• Q7Z4J7
• Q9BUR1

Gene Name

• NUCB1

Ensembl ID

• ENST00000405315
• ENSP00000385923
• ENSG00000104805
• ENST00000407032
• ENSP00000385211

Symbol

• NUC
• NUC
• CALNUC

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	0.97
disease perturbation	0.95
viral protein	0.8
cellular component	0.67
virus	0.66

Protein Classes

PANTHER Classes

Protein / Nucleic Acid Binding / Nucleobindin-1

Protein / Calcium-binding Protein / Intracellular Calcium-sensing Protein / Calmodulin / Nucleobindin-1

Protein / Calcium-binding Protein / Annexin / Nucleobindin-1

DTO Classes

Protein / Calcium-binding Protein / Intracellular Calcium-sensing Protein / Calmodulin / Nucleobindin-1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1096.27   (req: < 5)

Gene RIFs: 12   (req: <= 3)

Antibodies: 259   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1096.27   (req: >= 5)

Gene RIFs: 12   (req: > 3)

Antibodies: 259   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0