Protein Classes
Protein Summary
Major calcium-binding protein of the Golgi. May have a role in calcium homeostasis (By similarity). This gene encodes a member of a small calcium-binding EF-hand protein family. The encoded protein is thought to have a key role in Golgi calcium homeostasis and Ca(2+)-regulated signal transduction events. [provided by RefSeq, Jun 2010]
- ENST00000405315
- ENSP00000385923
- ENSG00000104805
- ENST00000407032
- ENSP00000385211
- NUC
- NUC
- CALNUC
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
kinase perturbation | 0.97 | ||
disease perturbation | 0.95 | ||
viral protein | 0.8 | ||
cellular component | 0.67 | ||
virus | 0.66 | ||
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 242.22 (req: < 5)
Gene RIFs: 12 (req: <= 3)
Antibodies: 259 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 242.22 (req: >= 5)
Gene RIFs: 12 (req: > 3)
Antibodies: 259 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 7
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 2
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Active Ligands (2)
1 – 2 of 2
GWAS Traits (12)
Items per page:
1 – 5 of 12
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
reticulocyte measurement | 3 | 5 | 6 | 96.1 | |||||
red blood cell distribution width | 4 | 3 | 5 | 95.1 | |||||
reticulocyte count | 6 | 4 | 12 | 94.4 | |||||
testosterone measurement | 5 | 5 | 5 | 87.6 | |||||
eosinophil count | 3 | 1 | 3 | 70.9 | |||||
Items per page:
1 – 5 of 12
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
reticulocyte measurement | 6 | 96.1 | |||||
red blood cell distribution width | 5 | 95.1 | |||||
reticulocyte count | 12 | 94.4 | |||||
testosterone measurement | 5 | 87.6 | |||||
eosinophil count | 3 | 70.9 | |||||
Orthologs (9)
1 – 5 of 9
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Mouse | MGI:97388 | 18220 | ||||||
Rat | RGD:620030 | 84595 | ||||||
Dog | nucleobindin 1 | VGNC:53746 | 484391 | |||||
Cow | nucleobindin 1 | VGNC:32318 | 505351 | |||||
Pig | nucleobindin 1 | 100512538 | ||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Mouse | ||||||
Rat | ||||||
Dog | nucleobindin 1 | |||||
Cow | nucleobindin 1 | |||||
Pig | nucleobindin 1 | |||||
Protein Structure (1 Structure, 1 AlphaFold Model)
Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB
1 – 1 of 1
PDB Structure Id | Ligand | Method | Resolution (Å) | Residues | Fraction of Total Protein | Pub Year | Title |
|---|
PDB Structure Id | Fraction of Total Protein | Resolution | Pub Year |
|---|
Pathways (4)
Reactome (4)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 4 of 4
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Metabolism of proteins | ||||
Reactome | Post-translational protein modification | ||||
Reactome | Post-translational protein phosphorylation | ||||
Reactome | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Metabolism of proteins | ||||
Post-translational protein modification | ||||
Post-translational protein phosphorylation | ||||
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) | ||||
Gene Ontology Terms (21)
Functions (3)
Components (14)
Processes (4)
Items per page:
10
1 – 3 of 3
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Protein-Protein Interactions (169)
1 – 10 of 169
PRXL2B
Family: Enzyme
Novelty: 0.34235664
p_int: 0.999999771
p_ni: 2.29e-7
p_wrong: 1e-9
Score: 0.279
Data Source: BioPlex,STRINGDB
ADCYAP1
Family: Enzyme
Novelty: 0.00080219
p_int: 0.999998175
p_ni: 0.000001825
Score: 0.191
Data Source: BioPlex,STRINGDB
HINT3
Novelty: 1.14285714
p_int: 0.999986754
p_ni: 0.000013246
Data Source: BioPlex
DKKL1
Novelty: 0.00544618
p_int: 0.999952017
p_ni: 0.000047983
Data Source: BioPlex
NUCB2
Novelty: 0.00831106
p_int: 0.999893244
p_ni: 0.000106756
Data Source: BioPlex
MANSC1
Novelty: 0.91681036
p_int: 0.999785303
p_ni: 0.000214697
Data Source: BioPlex
FGL1
Novelty: 0.02650803
p_int: 0.999704506
p_ni: 0.000295493
Data Source: BioPlex
CSTL1
Novelty: 0.13370814
p_int: 0.999481254
p_ni: 0.000518746
Data Source: BioPlex
RLN1
Novelty: 0.03992636
p_int: 0.994817759
p_ni: 0.005182241
Data Source: BioPlex
FGF3
Novelty: 0.00474087
p_int: 0.988794845
p_ni: 0.011205154
Data Source: BioPlex
Publication Statistics
PubMed Score 242.22
PubMed score by year
PubTator Score 166.97
PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by:
UniProt Keyword
No Header | No Header | ||
|---|---|---|---|