Tchem NUCB1 Nucleobindin-1

Protein Classes

PANTHER Classes

Protein / Nucleic Acid Binding / Nucleobindin-1

Protein / Calcium-binding Protein / Intracellular Calcium-sensing Protein / Calmodulin / Nucleobindin-1

Protein / Calcium-binding Protein / Annexin / Nucleobindin-1

DTO Classes

Protein / Calcium-binding Protein / Intracellular Calcium-sensing Protein / Calmodulin / Nucleobindin-1

Protein Summary

Description

Major calcium-binding protein of the Golgi. May have a role in calcium homeostasis (By similarity). This gene encodes a member of a small calcium-binding EF-hand protein family. The encoded protein is thought to have a key role in Golgi calcium homeostasis and Ca(2+)-regulated signal transduction events. [provided by RefSeq, Jun 2010]

Uniprot Accession IDs

• Q02818
• B2RD64
• Q15838
• Q7Z4J7
• Q9BUR1

Gene Name

• NUCB1

Ensembl ID

• ENST00000405315
• ENSP00000385923
• ENSG00000104805
• ENST00000407032
• ENSP00000385211

Symbol

• NUC
• NUC
• CALNUC

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	0.97
disease perturbation	0.95
viral protein	0.8
cellular component	0.67
virus	0.66

Related Tools

GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 233.39   (req: < 5)

Gene RIFs: 12   (req: <= 3)

Antibodies: 259   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 233.39   (req: >= 5)

Gene RIFs: 12   (req: > 3)

Antibodies: 259   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Active Ligands (2)

Explore Active Ligands

1 – 2 of 2

KML110

NUCB1Tchem

IC50 : 5.01999998

MJN228

NUCB1Tchem

IC50 : 5.48000002

Orthologs (9)

1 – 5 of 9

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Mouse	nucleobindin 1	MGI:97388	18220
Rat	nucleobindin 1	RGD:620030	84595
Dog	nucleobindin 1	VGNC:53746	484391
Cow	nucleobindin 1	VGNC:32318	505351
Pig	nucleobindin 1		100512538

Species	Name	OMA	EggNOG	Inparanoid
Mouse	nucleobindin 1
Rat	nucleobindin 1
Dog	nucleobindin 1
Cow	nucleobindin 1
Pig	nucleobindin 1

Protein Structure (1 Structure, 1 AlphaFold Model)

Representation

  axes   backbone   ball+stick   cartoon   rocket   rope   spacefill

Color Scheme

  target   atomindex   bfactor   chainname   electrostatic   element   hydrophobicity   resname   sstruc

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q02818-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1

PDB Structure Id	Ligand	Method	Resolution (Å)	Residues	Fraction of Total Protein	Pub Year	Title

PDB Structure Id	Fraction of Total Protein	Resolution	Pub Year

Pathways (4)

Reactome (4)

Metabolism of proteins (R-HSA-392499)

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Find Similar Targets

Items per page:

5

1 – 4 of 4

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Metabolism of proteins	2050 targets	R-HSA-392499
Reactome	Post-translational protein modification	1450 targets	R-HSA-597592
Reactome	Post-translational protein phosphorylation	107 targets	R-HSA-8957275
Reactome	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)	124 targets	R-HSA-381426

Name	Explore in Pharos	Explore in Source
Metabolism of proteins	2050 targets	R-HSA-392499
Post-translational protein modification	1450 targets	R-HSA-597592
Post-translational protein phosphorylation	107 targets	R-HSA-8957275
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)	124 targets	R-HSA-381426

Gene Ontology Terms (21)

Functions (3)

Components (14)

Processes (4)

Find Similar Targets

Items per page:

10

1 – 3 of 3

GO Term	Evidence	Assigned by
calcium ion binding	Inferred from Electronic Annotation (IEA)	Ensembl
DNA binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW
G-protein alpha-subunit binding	Inferred from Electronic Annotation (IEA)	Ensembl

Protein-Protein Interactions (169)

Explore Interacting Targets

1 – 10 of 169

• See Interactions on String-DB

PRXL2B

Tdark

Family: Enzyme

Novelty: 0.34235664

p_int: 0.999999771

p_ni: 2.29e-7

p_wrong: 1e-9

Score: 0.279

Data Source: BioPlex,STRINGDB

ADCYAP1

Tbio

Family: Enzyme

Novelty: 0.00080219

p_int: 0.999998175

p_ni: 0.000001825

Score: 0.191

Data Source: BioPlex,STRINGDB

HINT3

Tdark

Novelty: 1.14285714

p_int: 0.999986754

p_ni: 0.000013246

Data Source: BioPlex

DKKL1

Tbio

Novelty: 0.00544618

p_int: 0.999952017

p_ni: 0.000047983

Data Source: BioPlex

NUCB2

Tbio

Novelty: 0.00831106

p_int: 0.999893244

p_ni: 0.000106756

Data Source: BioPlex

MANSC1

Tdark

Novelty: 0.91681036

p_int: 0.999785303

p_ni: 0.000214697

Data Source: BioPlex

FGL1

Tbio

Novelty: 0.02650803

p_int: 0.999704506

p_ni: 0.000295493

Data Source: BioPlex

CSTL1

Tbio

Novelty: 0.13370814

p_int: 0.999481254

p_ni: 0.000518746

Data Source: BioPlex

RLN1

Tbio

Novelty: 0.03992636

p_int: 0.994817759

p_ni: 0.005182241

Data Source: BioPlex

FGF3

Tbio

Novelty: 0.00474087

p_int: 0.988794845

p_ni: 0.011205154

Data Source: BioPlex

Publication Statistics

PubMed Score  233.39

PubMed score by year

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PubTator Score  166.97

PubTator score by year

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Amino Acid Sequence

Residue Counts

Protein Sequence

Show Full Sequence

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UniProt Keyword Find Similar Targets

3D-structure
Calcium
Coiled coil
Complete proteome
Cytoplasm
DNA-binding
Glycoprotein
Golgi apparatus
Membrane
Metal-binding