Protein Summary
Major calcium-binding protein of the Golgi. May have a role in calcium homeostasis (By similarity). This gene encodes a member of a small calcium-binding EF-hand protein family. The encoded protein is thought to have a key role in Golgi calcium homeostasis and Ca(2+)-regulated signal transduction events. [provided by RefSeq, Jun 2010]
- ENST00000405315
- ENSP00000385923
- ENSG00000104805
- ENST00000407032
- ENSP00000385211
- NUC
- NUC
- CALNUC
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
kinase perturbation | 0.97 | ||
disease perturbation | 0.95 | ||
viral protein | 0.8 | ||
cellular component | 0.67 | ||
virus | 0.66 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 242.22 (req: < 5)
Gene RIFs: 12 (req: <= 3)
Antibodies: 259 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 242.22 (req: >= 5)
Gene RIFs: 12 (req: > 3)
Antibodies: 259 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 7
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 2
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (2)
Protein-Protein Interactions (169)
PRXL2B
Family: Enzyme
Novelty: 0.34235664
p_int: 0.999999771
p_ni: 2.29e-7
p_wrong: 1e-9
Score: 0.279
Data Source: BioPlex,STRINGDB
ADCYAP1
Family: Enzyme
Novelty: 0.00080219
p_int: 0.999998175
p_ni: 0.000001825
Score: 0.191
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (4)
Reactome (4)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Metabolism of proteins | ||||
Reactome | Post-translational protein modification | ||||
Reactome | Post-translational protein phosphorylation | ||||
Reactome | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Metabolism of proteins | ||||
Post-translational protein modification | ||||
Post-translational protein phosphorylation | ||||
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) | ||||
Viral Interactions (0)
Gene Ontology Terms (21)
Functions (3)
Components (14)
Processes (4)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Disease Associations ()
GWAS Traits (12)
Items per page:
1 – 5 of 12
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
reticulocyte measurement | 3 | 5 | 6 | 96.1 | |||||
red blood cell distribution width | 4 | 3 | 5 | 95.1 | |||||
reticulocyte count | 6 | 4 | 12 | 94.4 | |||||
testosterone measurement | 5 | 5 | 5 | 87.6 | |||||
eosinophil count | 3 | 1 | 3 | 70.9 | |||||
Items per page:
1 – 5 of 12
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
reticulocyte measurement | 6 | 96.1 | |||||
red blood cell distribution width | 5 | 95.1 | |||||
reticulocyte count | 12 | 94.4 | |||||
testosterone measurement | 5 | 87.6 | |||||
eosinophil count | 3 | 70.9 | |||||
Find similar targets by:
IDG Resources
Orthologs (9)
1 – 5 of 9
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Mouse | MGI:97388 | 18220 | ||||||
Rat | RGD:620030 | 84595 | ||||||
Dog | nucleobindin 1 | VGNC:53746 | 484391 | |||||
Cow | nucleobindin 1 | VGNC:32318 | 505351 | |||||
Pig | nucleobindin 1 | 100512538 | ||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Mouse | ||||||
Rat | ||||||
Dog | nucleobindin 1 | |||||
Cow | nucleobindin 1 | |||||
Pig | nucleobindin 1 | |||||
Publication Statistics
PubMed Score 242.22
PubMed score by year
PubTator Score 166.97
PubTator score by year
Related Publications
Text Mined References (32)
GeneRif Annotations (12)
Items per page:
0 of 0
PMID | Year | Title |
|---|