You are using an outdated browser. Please upgrade your browser to improve your experience.

Tchem
NUCB1
Nucleobindin-1

Protein Summary
Description
Major calcium-binding protein of the Golgi. May have a role in calcium homeostasis (By similarity). This gene encodes a member of a small calcium-binding EF-hand protein family. The encoded protein is thought to have a key role in Golgi calcium homeostasis and Ca(2+)-regulated signal transduction events. [provided by RefSeq, Jun 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000405315
  • ENSP00000385923
  • ENSG00000104805
  • ENST00000407032
  • ENSP00000385211

Symbol
  • NUC
  • NUC
  • CALNUC
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.97
disease perturbation
0.95
viral protein
0.8
cellular component
0.67
virus
0.66


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1096.27   (req: < 5)
Gene RIFs: 12   (req: <= 3)
Antibodies: 259   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1096.27   (req: >= 5)
Gene RIFs: 12   (req: > 3)
Antibodies: 259   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0