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Tchem
FKBP4
Peptidyl-prolyl cis-trans isomerase FKBP4

Protein Classes
Protein Summary
Description
Immunophilin protein with PPIase and co-chaperone activities. Component of steroid receptors heterocomplexes through interaction with heat-shock protein 90 (HSP90). May play a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors between cytoplasm and nuclear compartments. The isomerase activity controls neuronal growth cones via regulation of TRPC1 channel opening. Acts also as a regulator of microtubule dynamics by inhibiting MAPT/TAU ability to promote microtubule assembly. May have a protective role against oxidative stress in mitochondria. The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds to the immunosuppressants FK506 and rapamycin. It has high structural and functional similarity to FK506-binding protein 1A (FKBP1A), but unlike FKBP1A, th ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000001008
  • ENSP00000001008
  • ENSG00000004478

Symbol
  • FKBP52
  • HBI
  • p52
  • Hsp56
  • FKBP51
  • FKBP52
  • FKBP59
  • PPIase
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
molecular function
1
kinase perturbation
0.99
interacting protein
0.9
protein domain
0.85


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 479.32   (req: < 5)
Gene RIFs: 47   (req: <= 3)
Antibodies: 600   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 479.32   (req: >= 5)
Gene RIFs: 47   (req: > 3)
Antibodies: 600   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 25
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Approved Drugs (1)
1 – 1 of 1
ciclosporin
chemical structure image
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
testosterone measurement
6
1
6
98.3
sex hormone-binding globulin measurement
4
1
4
94.7
estradiol measurement
1
1
1
84.8
BMI-adjusted waist-hip ratio
1
1
1
61.2
vital capacity
1
1
1
50.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
testosterone measurement
6
98.3
sex hormone-binding globulin measurement
4
94.7
estradiol measurement
1
84.8
BMI-adjusted waist-hip ratio
1
61.2
vital capacity
1
50.1
Protein Data Bank (10)
1 – 5 of 10
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (21)
Attenuation phase (R-HSA-3371568)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 12
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Attenuation phase
Reactome
Cellular response to heat stress
Reactome
Cellular responses to external stimuli
Reactome
Cellular responses to stress
Reactome
ESR-mediated signaling
Name
Explore in Pharos
Explore in Source
Attenuation phase
Cellular response to heat stress
Cellular responses to external stimuli
Cellular responses to stress
ESR-mediated signaling
Gene Ontology Terms (35)
Items per page:
10
1 – 10 of 11
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Traceable Author Statement (TAS)
UniProtKB
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (179)
1 – 10 of 179
HSP90AA5P
Tdark
p_int: 0.999987372
p_ni: 0.000012628
Data Source: BioPlex
HSP90AB4P
Tdark
p_int: 0.999628774
p_ni: 0.000371225
p_wrong: 2e-9
Data Source: BioPlex
MGME1
Tbio
Family: Enzyme
Novelty: 0.05284418
p_int: 0.99892446
p_ni: 0.00107554
Score: 0.244
Data Source: BioPlex,STRINGDB
NPB
Tdark
Novelty: 0.00936692
p_int: 0.990662058
p_ni: 0.009337942
Score: 0.189
Data Source: BioPlex,STRINGDB
HSP90AA1
Tchem
Novelty: 0.00016774
p_int: 0.929137359
p_ni: 0.070862641
Score: 0.995
Data Source: BioPlex,Reactome,STRINGDB
HSP90AB1
Tchem
Novelty: 0.00907961
p_int: 0.923851483
p_ni: 0.076148517
Score: 0.987
Data Source: BioPlex,Reactome,STRINGDB
STIP1
Tbio
Novelty: 0.00590952
Score: 0.987
Data Source: Reactome,STRINGDB
NR3C1
Tclin
Family: NR
Novelty: 0.00029396
Score: 0.982
Data Source: STRINGDB
PTGES3
Tbio
Family: Enzyme
Novelty: 0.0082783
Score: 0.982
Data Source: Reactome,STRINGDB
AR
Tclin
Family: NR
Novelty: 0.00013531
Score: 0.982
Data Source: STRINGDB
Publication Statistics
PubMed Score  479.32

PubMed score by year
PubTator Score  154.97

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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