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Tchem
MAP3K10
Mitogen-activated protein kinase kinase kinase 10

Protein Summary
Description
Activates the JUN N-terminal pathway. The protein encoded by this gene is a member of the serine/threonine kinase family. This kinase has been shown to activate MAPK8/JNK and MKK4/SEK1, and this kinase itself can be phoshorylated, and thus activated by JNK kinases. This kinase functions preferentially on the JNK signaling pathway, and is reported to be involved in nerve growth factor (NGF) induced neuronal apoptosis. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000253055
  • ENSP00000253055
  • ENSG00000130758

Symbol
  • MLK2
  • MST
  • MST
  • MLK2
  • MEKK10
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
1
protein domain
0.97
biological process
0.9
histone modification site profile
0.86
hub protein
0.75


Related Tools
Dark Kinase Knowledgebase
The Dark Kinase Knowledgebase is an an online compendium of knowledge and experimental results of understudied kinases.
ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 25.35   (req: < 5)
Gene RIFs: 13   (req: <= 3)
Antibodies: 254   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 25.35   (req: >= 5)
Gene RIFs: 13   (req: > 3)
Antibodies: 254   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 21
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 7
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
birth weight
2
1
2
63.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
birth weight
2
63.1
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
mitogen-activated protein kinase kinase kinase 10
VGNC:11235
468880
Macaque
mitogen-activated protein kinase kinase kinase 10
700477
Mouse
MGI:1346879
269881
Rat
RGD:1308381
308463
Dog
mitogen-activated protein kinase kinase kinase 10
VGNC:53748
484504
Species
Name
OMA
EggNOG
Inparanoid
Chimp
mitogen-activated protein kinase kinase kinase 10
Macaque
mitogen-activated protein kinase kinase kinase 10
Mouse
Rat
Dog
mitogen-activated protein kinase kinase kinase 10
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q02779-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (10)
Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
PathwayCommons: panther
Huntington disease
PathwayCommons: panther
p38 MAPK pathway
PathwayCommons: inoh
Positive regulation of (Transcription of SOCS by STAT dimer) in JAK STAT pathway ( JAK-STAT pathway and regulation pathway Diagram )
PathwayCommons: inoh
VEGF signaling pathway ( VEGF signaling pathway )
PathwayCommons: inoh
AKT(PKB)-Bad signaling ( EPO signaling pathway(JAK2 STAT1 STAT3 STAT5) )
Name
Explore in Pharos
Explore in Source
Huntington disease
p38 MAPK pathway
Positive regulation of (Transcription of SOCS by STAT dimer) in JAK STAT pathway ( JAK-STAT pathway and regulation pathway Diagram )
VEGF signaling pathway ( VEGF signaling pathway )
AKT(PKB)-Bad signaling ( EPO signaling pathway(JAK2 STAT1 STAT3 STAT5) )
Gene Ontology Terms (22)
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (39)
1 – 10 of 39
MAP2K3
Tchem
Family: Kinase
Novelty: 0.00349605
Score: 0.924
Data Source: STRINGDB
MAP2K6
Tchem
Family: Kinase
Novelty: 0.00569655
Score: 0.922
Data Source: STRINGDB
MAPK8IP2
Tbio
Family: Enzyme
Novelty: 0.01788453
Score: 0.845
Data Source: STRINGDB
MAPK8IP1
Tbio
Family: Enzyme
Novelty: 0.00284875
Score: 0.782
Data Source: STRINGDB
KIF17
Tbio
Novelty: 0.00830285
Score: 0.671
Data Source: STRINGDB
HTT
Tchem
Novelty: 0.00034051
Score: 0.669
Data Source: STRINGDB
MAP2K4
Tchem
Family: Kinase
Novelty: 0.00252847
Score: 0.662
Data Source: STRINGDB
CLTC
Tbio
Novelty: 0.00256674
Score: 0.651
Data Source: STRINGDB
HPCA
Tbio
Novelty: 0.01360155
Score: 0.647
Data Source: STRINGDB
CDC42
Tchem
Family: Enzyme
Novelty: 0.00032619
Score: 0.631
Data Source: STRINGDB
Publication Statistics
PubMed Score  25.35

PubMed score by year
PubTator Score  39.27

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer