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Tclin
TEK
Angiopoietin-1 receptor

Protein Summary
Description
Tyrosine-protein kinase that acts as cell-surface receptor for ANGPT1, ANGPT2 and ANGPT4 and regulates angiogenesis, endothelial cell survival, proliferation, migration, adhesion and cell spreading, reorganization of the actin cytoskeleton, but also maintenance of vascular quiescence. Has anti-inflammatory effects by preventing the leakage of proinflammatory plasma proteins and leukocytes from blood vessels. Required for normal angiogenesis and heart development during embryogenesis. Required for post-natal hematopoiesis. After birth, activates or inhibits angiogenesis, depending on the context. Inhibits angiogenesis and promotes vascular stability in quiescent vessels, where endothelial cells have tight contacts. In quiescent vessels, ANGPT1 oligomers recruit TEK to cell-cell contacts, forming complexes with TEK molecules from adjoining cells, and this leads to preferential activation of phosphatidylinositol 3-kinase and the AKT1 signaling cascades. In migrating endothelial cells that ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000380036
  • ENSP00000369375
  • ENSG00000120156
  • ENST00000406359
  • ENSP00000383977
  • ENST00000519097
  • ENSP00000430686

Symbol
  • TIE2
  • VMCM
  • VMCM1
  • TIE2
  • VMCM
  • GLC3E
  • TIE-2
  • VMCM1
  • CD202B
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
protein domain
1
molecular function
0.98
transcription factor perturbation
0.96
gene perturbation
0.91


Related Tools
ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1174.35   (req: < 5)
Gene RIFs: 197   (req: <= 3)
Antibodies: 1276   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1174.35   (req: >= 5)
Gene RIFs: 197   (req: > 3)
Antibodies: 1276   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 50
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 273
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2
Approved Drugs (2)
1 – 2 of 2
crizotinib
chemical structure image
cabozantinib
chemical structure image
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hepatocyte growth factor measurement
1
1
1
90.8
endothelial growth factor measurement
1
1
1
90.8
angiopoietin-2 receptor measurement
1
1
1
90.8
angiopoietin-2 measurement
1
1
1
90.8
angiopoietin-1 receptor measurement
1
2
2
87.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hepatocyte growth factor measurement
1
90.8
endothelial growth factor measurement
1
90.8
angiopoietin-2 receptor measurement
1
90.8
angiopoietin-2 measurement
1
90.8
angiopoietin-1 receptor measurement
2
87.5
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
TEK receptor tyrosine kinase
VGNC:10114
465028
Macaque
TEK receptor tyrosine kinase
707455
Mouse
MGI:98664
21687
Rat
RGD:620980
89804
Dog
TEK receptor tyrosine kinase
VGNC:47241
403714
Species
Name
OMA
EggNOG
Inparanoid
Chimp
TEK receptor tyrosine kinase
Macaque
TEK receptor tyrosine kinase
Mouse
Rat
Dog
TEK receptor tyrosine kinase
Protein Structure (14 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q02763-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 14
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (186)
Cell surface interactions at the vascular wall (R-HSA-202733)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 12
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cell surface interactions at the vascular wall
Reactome
Cytokine Signaling in Immune system
Reactome
FLT3 Signaling
Reactome
Hemostasis
Reactome
Immune System
Name
Explore in Pharos
Explore in Source
Cell surface interactions at the vascular wall
Cytokine Signaling in Immune system
FLT3 Signaling
Hemostasis
Immune System
Gene Ontology Terms (64)
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (215)
1 – 10 of 215
ANGPT2
Tbio
Novelty: 0.00116183
Score: 0.999
Data Source: Reactome,STRINGDB
ANGPT1
Tbio
Novelty: 0.00115408
Score: 0.999
Data Source: Reactome,STRINGDB
ANGPT4
Tbio
Novelty: 0.02566013
Score: 0.978
Data Source: Reactome,STRINGDB
VEGFA
Tclin
Novelty: 0.0000378
Score: 0.968
Data Source: STRINGDB
GRB14
Tbio
Novelty: 0.02565119
Score: 0.967
Data Source: Reactome,STRINGDB
GRB2
Tchem
Novelty: 0.00091605
Score: 0.959
Data Source: Reactome,STRINGDB
DOK2
Tbio
Novelty: 0.02651438
Score: 0.957
Data Source: Reactome,STRINGDB
PTPN11
Tchem
Family: Enzyme
Novelty: 0.00073124
Score: 0.955
Data Source: Reactome,STRINGDB
SHC1
Tchem
Novelty: 0.00083615
Score: 0.953
Data Source: Reactome,STRINGDB
MMP2
Tchem
Family: Enzyme
Novelty: 0.00012762
Score: 0.95
Data Source: STRINGDB
Publication Statistics
PubMed Score  1174.35

PubMed score by year
PubTator Score  706.74

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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