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Tclin
MAP2K1
Dual specificity mitogen-activated protein kinase kinase 1

Protein Summary
Description
Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Binding of extracellular ligands such as growth factors, cytokines and hormones to their cell-surface receptors activates RAS and this initiates RAF1 activation. RAF1 then further activates the dual-specificity protein kinases MAP2K1/MEK1 and MAP2K2/MEK2. Both MAP2K1/MEK1 and MAP2K2/MEK2 function specifically in the MAPK/ERK cascade, and catalyze the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in the extracellular signal-regulated kinases MAPK3/ERK1 and MAPK1/ERK2, leading to their activation and further transduction of the signal within the MAPK/ERK cascade. Depending on the cellular context, this pathway mediates diverse biological functions such as cell growth, adhesion, survival and differentiation, predominantly through the regulation of transcription, metabolism and cytoskeletal rearrangements. One target of th ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000307102
  • ENSP00000302486
  • ENSG00000169032

Symbol
  • MEK1
  • PRKMK1
  • CFC3
  • MEK1
  • MKK1
  • MAPKK1
  • PRKMK1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
chemical
1
hub protein
1
kinase
1
molecular function
1


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1566.24   (req: < 5)
Gene RIFs: 223   (req: <= 3)
Antibodies: 3023   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1566.24   (req: >= 5)
Gene RIFs: 223   (req: > 3)
Antibodies: 3023   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 47
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 255
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 7