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Tclin
MAP2K1
Dual specificity mitogen-activated protein kinase kinase 1

Protein Summary
Description
Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Binding of extracellular ligands such as growth factors, cytokines and hormones to their cell-surface receptors activates RAS and this initiates RAF1 activation. RAF1 then further activates the dual-specificity protein kinases MAP2K1/MEK1 and MAP2K2/MEK2. Both MAP2K1/MEK1 and MAP2K2/MEK2 function specifically in the MAPK/ERK cascade, and catalyze the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in the extracellular signal-regulated kinases MAPK3/ERK1 and MAPK1/ERK2, leading to their activation and further transduction of the signal within the MAPK/ERK cascade. Depending on the cellular context, this pathway mediates diverse biological functions such as cell growth, adhesion, survival and differentiation, predominantly through the regulation of transcription, metabolism and cytoskeletal rearrangements. One target of th ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000307102
  • ENSP00000302486
  • ENSG00000169032

Symbol
  • MEK1
  • PRKMK1
  • CFC3
  • MEK1
  • MKK1
  • MAPKK1
  • PRKMK1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
chemical
1
hub protein
1
kinase
1
molecular function
1


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 959.74   (req: < 5)
Gene RIFs: 223   (req: <= 3)
Antibodies: 3023   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 959.74   (req: >= 5)
Gene RIFs: 223   (req: > 3)
Antibodies: 3023   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 47
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 230
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 7
Protein Data Bank (40)
1 – 5 of 40
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (303)
Axon guidance (R-HSA-422475)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 52
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Axon guidance
Reactome
Cytokine Signaling in Immune system
Reactome
Developmental Biology
Reactome
Disease
Reactome
Diseases of signal transduction
Name
Explore in Pharos
Explore in Source
Axon guidance
Cytokine Signaling in Immune system
Developmental Biology
Disease
Diseases of signal transduction
Gene Ontology Terms (58)
Items per page:
10
1 – 10 of 10
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
MGI
Inferred from Direct Assay (IDA)
MGI
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (410)
1 – 10 of 410
BRAF
Tclin
Family: Kinase
Novelty: 0.00382184
p_int: 0.999999989
p_ni: 9e-9
p_wrong: 2e-9
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
MAP2K2
Tclin
Family: Kinase
Novelty: 0.01210207
p_int: 0.999999978
p_ni: 2e-9
p_wrong: 2e-8
Score: 0.982
Data Source: BioPlex,Reactome,STRINGDB
FGB
Tbio
Novelty: 0.00757235
p_int: 0.996664432
p_ni: 0.003335543
p_wrong: 2.5e-8
Score: 0.908
Data Source: BioPlex,STRINGDB
P4HA1
Tchem
Family: Enzyme
Novelty: 0.02187424
p_int: 0.988622634
p_ni: 0.011376415
p_wrong: 9.51e-7
Score: 0.23
Data Source: BioPlex,STRINGDB
NUFIP1
Tbio
Novelty: 0.14861119
p_int: 0.977293989
p_ni: 0.022453383
p_wrong: 0.000252628
Data Source: BioPlex
NSUN5
Tbio
Family: Enzyme
Novelty: 0.13315656
p_int: 0.96617732
p_ni: 0.033817308
p_wrong: 0.000005371
Data Source: BioPlex
RNASE9
Tdark
Family: Enzyme
Novelty: 0.28571429
p_int: 0.918897782
p_ni: 0.071727783
p_wrong: 0.009374434
Score: 0.689
Data Source: BioPlex,STRINGDB
KSR2
Tbio
Family: Kinase
Novelty: 0.0686184
Score: 0.998
Data Source: STRINGDB
KSR1
Tbio
Family: Kinase
Novelty: 0.0074785
Score: 0.995
Data Source: Reactome,STRINGDB
HRAS
Tchem
Family: Enzyme
Novelty: 0.00008788
Score: 0.994
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score  959.74

PubMed score by year
PubTator Score  1225.77

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Sequence
MPKKKPTPIQLNPAPDGSAVNGTSSAETNLEALQKKLEELELDEQQRKRLEAFLTQKQKVGELKDDDFEK
1-70
ISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIVGFYGAFYSDGEIS
70-140
ICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFG
140-210
VSGQLIDSMANSFVGTRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVE
210-280
GDAAETPPRPRTPGRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERA
280-350
DLKQLMVHAFIKRSDAEEVDFAGWLCSTIGLNQPSTPTHAAGV
350-393
MPKKKPTPIQLNPAPDGSAVNGTSSAETNLEALQKKLEELELDEQQRKRLEAFLTQKQKVGELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAFIKRSDAEEVDFAGWLCSTIGLNQPSTPTHAAGV