Tbio GUCA2A Guanylin

Protein Summary

Description

Endogenous activator of intestinal guanylate cyclase. It stimulates this enzyme through the same receptor binding region as the heat-stable enterotoxins.

Uniprot Accession IDs

• Q02747

Gene Name

• GUCA2A

Ensembl ID

• ENST00000357001
• ENSP00000349493
• ENSG00000197273

Symbol

• GUCA2
• GUCA2
• STARA
• GCAP-I

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
cell type or tissue	0.78
gene perturbation	0.63
tissue	0.56
PubMedID	0.48
cell line	0.46

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 141.05   (req: < 5)

Gene RIFs: 15   (req: <= 3)

Antibodies: 170   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 141.05   (req: >= 5)

Gene RIFs: 15   (req: > 3)

Antibodies: 170   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0