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Tbio
GUCA2A
Guanylin

Protein Summary
Description
Endogenous activator of intestinal guanylate cyclase. It stimulates this enzyme through the same receptor binding region as the heat-stable enterotoxins.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000357001
  • ENSP00000349493
  • ENSG00000197273

Symbol
  • GUCA2
  • GUCA2
  • STARA
  • GCAP-I
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.78
gene perturbation
0.63
tissue
0.56
PubMedID
0.48
cell line
0.46


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 104.76   (req: < 5)
Gene RIFs: 14   (req: <= 3)
Antibodies: 170   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 104.76   (req: >= 5)
Gene RIFs: 14   (req: > 3)
Antibodies: 170   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
guanylate cyclase activator 2A
VGNC:6853
746977
Macaque
guanylate cyclase activator 2A
696455
Mouse
MGI:102738
14915
Rat
RGD:2766
25656
Dog
guanylate cyclase activator 2A
VGNC:41564
482446
Species
Name
OMA
EggNOG
Inparanoid
Chimp
guanylate cyclase activator 2A
Macaque
guanylate cyclase activator 2A
Mouse
Rat
Dog
guanylate cyclase activator 2A
Protein Structure (3 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q02747-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (57)
Digestion (R-HSA-8935690)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Digestion
Reactome
Digestion and absorption
Name
Explore in Pharos
Explore in Source
Digestion
Digestion and absorption
Gene Ontology Terms (4)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Non-traceable Author Statement (NAS)
UniProtKB
Protein-Protein Interactions (73)
1 – 10 of 73
GUCY2C
Tclin
Family: Kinase
Novelty: 0.00209733
Score: 0.994
Data Source: Reactome,STRINGDB
NPR3
Tchem
Novelty: 0.00227442
Score: 0.86
Data Source: STRINGDB
TMIGD1
Tbio
Novelty: 0.21889871
Score: 0.837
Data Source: STRINGDB
EMD
Tbio
Novelty: 0.00135202
Score: 0.8
Data Source: STRINGDB
GUCA2B
Tbio
Family: Enzyme
Novelty: 0.02002363
Score: 0.736
Data Source: STRINGDB
GUCA1A
Tbio
Family: Enzyme
Novelty: 0.01003665
Score: 0.728
Data Source: STRINGDB
CYREN
Tbio
Novelty: 0.00278834
Score: 0.718
Data Source: STRINGDB
GUCY2D
Tbio
Family: Kinase
Novelty: 0.00578343
Score: 0.7
Data Source: STRINGDB
CFTR
Tclin
Family: IC
Novelty: 0.00012639
Score: 0.681
Data Source: STRINGDB
CLCA1
Tbio
Family: IC
Novelty: 0.01111462
Score: 0.676
Data Source: STRINGDB
Publication Statistics
PubMed Score  104.76

PubMed score by year
PubTator Score  117.52

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer