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Tbio
GCNT1
Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase

Protein Summary
Description
Glycosyltransferase that catalyzes the transfer of an N-acetylglucosamine moiety onto mucin-type core 1 O-glycan to form the branched mucin-type core 2 O-glycan. Mucin-type core 2 O-glycans play an important role in leukocyte extravasation as they serve as scaffolds for the display of the selectin ligand sialyl Lewis X by leukocytes. This gene is a member of the beta-1,6-N-acetylglucosaminyltransferase gene family. It is essential to the formation of Gal beta 1-3(GlcNAc beta 1-6)GalNAc structures and the core 2 O-glycan branch. The gene coding this enzyme was originally mapped to 9q21, but was later localized to 9q13. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000376730
  • ENSP00000365920
  • ENSG00000187210
  • ENST00000442371
  • ENSP00000415454
  • ENST00000444201
  • ENSP00000390703

Symbol
  • NACGT2
  • G6NT
  • C2GNT
  • C2GNT1
  • NACGT2
  • NAGCT2
  • C2GNT-L
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.97
transcription factor perturbation
0.84
virus perturbation
0.79
cellular component
0.73
transcription factor
0.72


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 73.5   (req: < 5)
Gene RIFs: 30   (req: <= 3)
Antibodies: 211   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 73.5   (req: >= 5)
Gene RIFs: 30   (req: > 3)
Antibodies: 211   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil count
2
2
2
81.3
myeloid white cell count
1
1
1
61
leukocyte count
1
1
1
56.2
monocyte count
1
1
1
47.7
1
1
1
45.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil count
2
81.3
myeloid white cell count
1
61
leukocyte count
1
56.2
monocyte count
1
47.7
1
45.7
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
glucosaminyl (N-acetyl) transferase 1, core 2
704639
Mouse
MGI:95676
14537
Rat
RGD:621370
64043
Dog
glucosaminyl (N-acetyl) transferase 1, core 2
484158
Horse
glucosaminyl (N-acetyl) transferase 1, core 2
100061416
Species
Name
OMA
EggNOG
Inparanoid
Macaque
glucosaminyl (N-acetyl) transferase 1, core 2
Mouse
Rat
Dog
glucosaminyl (N-acetyl) transferase 1, core 2
Horse
glucosaminyl (N-acetyl) transferase 1, core 2
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q02742-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (8)
Metabolism of proteins (R-HSA-392499)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of proteins
Reactome
O-linked glycosylation
Reactome
O-linked glycosylation of mucins
Reactome
Post-translational protein modification
Name
Explore in Pharos
Explore in Source
Metabolism of proteins
O-linked glycosylation
O-linked glycosylation of mucins
Post-translational protein modification
Protein-Protein Interactions (145)
1 – 10 of 145
UBA52
Tbio
Novelty:  0.01637744
p_int:  0.999387237
p_ni:  0.000611873
p_wrong:  8.89e-7
Score:  0.188
Data Source:  BioPlex,STRINGDB
SCGB2A1
Tbio
Novelty:  0.01902973
p_int:  0.996425919
p_ni:  0.003574037
p_wrong:  4.4e-8
Data Source:  BioPlex
TTC19
Tbio
Novelty:  0.08251578
p_int:  0.99095806
p_ni:  0.00904194
Score:  0.163
Data Source:  BioPlex,STRINGDB
TMEM106A
Tbio
Novelty:  0.32470607
p_int:  0.975320199
p_ni:  0.024505696
p_wrong:  0.000174105
Data Source:  BioPlex
SCGB2A2
Tbio
Novelty:  0.01594053
p_int:  0.972551627
p_ni:  0.0274464
p_wrong:  0.000001973
Data Source:  BioPlex
HFE
Tbio
Novelty:  0.00042077
p_int:  0.970333776
p_ni:  0.029446409
p_wrong:  0.000219815
Data Source:  BioPlex
PTCH1
Tbio
Novelty:  0.00077635
p_int:  0.969645813
p_ni:  0.030349422
p_wrong:  0.000004764
Data Source:  BioPlex
ISLR
Tbio
Novelty:  0.02936208
p_int:  0.955112803
p_ni:  0.044869615
p_wrong:  0.000017582
Score:  0.172
Data Source:  BioPlex,STRINGDB
SLC25A46
Tbio
Family:  Transporter
Novelty:  0.02720146
p_int:  0.877511586
p_ni:  0.087999419
p_wrong:  0.034488995
Score:  0.158
Data Source:  BioPlex,STRINGDB
RLN1
Tbio
Novelty:  0.03992636
p_int:  0.866171972
p_ni:  0.127380832
p_wrong:  0.006447196
Data Source:  BioPlex
Publication Statistics
PubMed Score  73.50

PubMed score by year
PubTator Score  63.18

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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