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Tclin
GHRHR
Growth hormone-releasing hormone receptor

Protein Summary
Description
Receptor for GRF, coupled to G proteins which activate adenylyl cyclase. Stimulates somatotroph cell growth, growth hormone gene transcription and growth hormone secretion. This gene encodes a receptor for growth hormone-releasing hormone. Binding of this hormone to the receptor leads to synthesis and release of growth hormone. Mutations in this gene have been associated with isolated growth hormone deficiency (IGHD), also known as Dwarfism of Sindh, a disorder characterized by short stature. [provided by RefSeq, Jun 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000326139
  • ENSP00000320180
  • ENSG00000106128

Symbol
  • GRFR
  • GHRFR
  • IGHD4
  • IGHD1B
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.96
ligand (chemical)
0.86
cellular component
0.82
co-expressed gene
0.79
cell type or tissue
0.75


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 170.93   (req: < 5)
Gene RIFs: 55   (req: <= 3)
Antibodies: 290   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 170.93   (req: >= 5)
Gene RIFs: 55   (req: > 3)
Antibodies: 290   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 30
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 3
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (172)
GHRH
Tbio
Novelty:  0.00058152
Score:  0.996
Data Source:  Reactome,STRINGDB
TSHB
Tbio
Novelty:  0.00194403
Score:  0.965
Data Source:  STRINGDB
POMC
Tbio
Novelty:  0.00002436
Score:  0.961
Data Source:  STRINGDB
CGA
Tbio
Novelty:  0.00394017
Score:  0.96
Data Source:  STRINGDB
Q5JWF2
Tbio
Novelty:  0.00284739
Score:  0.956
Data Source:  STRINGDB
P63092
Tbio
Novelty:  0.00284739
Score:  0.956
Data Source:  STRINGDB
P84996
Tbio
Novelty:  0.00284739
Score:  0.956
Data Source:  STRINGDB
O95467
Tbio
Novelty:  0.00284739
Score:  0.956
Data Source:  STRINGDB
FSHB
Tbio
Novelty:  0.00510815
Score:  0.955
Data Source:  STRINGDB
CRH
Tbio
Novelty:  0.000147
Score:  0.954
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (12)
Class B/2 (Secretin family receptors) (R-HSA-373080)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Class B/2 (Secretin family receptors)
Reactome
G alpha (s) signalling events
Reactome
GPCR downstream signalling
Reactome
GPCR ligand binding
Reactome
Glucagon-type ligand receptors
Name
Explore in Pharos
Explore in Source
Class B/2 (Secretin family receptors)
G alpha (s) signalling events
GPCR downstream signalling
GPCR ligand binding
Glucagon-type ligand receptors
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (39)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Mutant Phenotype (IMP)
BHF-UCL
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred by Curator (IC)
BHF-UCL
Disease Associations (null)
No disease associations found
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
3
2
6
94.8
1
1
1
84.9
2
2
0
1.2
64.4
bone density
1
1
2
59.8
urolithiasis
1
1
0
1.1
38.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
6
94.8
1
84.9
0
1.2
64.4
bone density
2
59.8
urolithiasis
0
1.1
38.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
growth hormone releasing hormone receptor
VGNC:4368
463331
Macaque
growth hormone releasing hormone receptor
696430
Mouse
MGI:95710
14602
Rat
RGD:2688
25321
Dog
growth hormone releasing hormone receptor
VGNC:41208
482385
Species
Name
OMA
EggNOG
Inparanoid
Chimp
growth hormone releasing hormone receptor
Macaque
growth hormone releasing hormone receptor
Mouse
Rat
Dog
growth hormone releasing hormone receptor
Publication Statistics
PubMed Score 170.93
PubMed score by year
PubTator Score 146.38
PubTator score by year
Patents
Patents by year
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Related Publications
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0 of 0
PMID
Year
Title