Tbio CACNB1 Voltage-dependent L-type calcium channel subunit beta-1

Protein Summary

Description

Regulatory subunit of L-type calcium channels (PubMed:1309651, PubMed:8107964, PubMed:15615847). Regulates the activity of L-type calcium channels that contain CACNA1A as pore-forming subunit (By similarity). Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit and increases the presence of the channel complex at the cell membrane (PubMed:15615847). Required for functional expression L-type calcium channels that contain CACNA1D as pore-forming subunit (PubMed:1309651). Regulates the activity of L-type calcium channels that contain CACNA1B as pore-forming subunit (PubMed:8107964). The protein encoded by this gene belongs to the calcium channel beta subunit family. It plays an important role in the calcium channel by modulating G protein inhibition, increasing peak calcium current, controlling the alpha-1 subunit membrane targeting and shifting the voltage dependence of activation and inactivation. Alternative splicing occurs at this locus and three transcript variants encoding three distinct isoforms have been identified. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q02641
• A8K114
• O15331
• Q02639
• Q02640
• Q8N3X9
• Q9C085
• Q9UD79
• CAB1

Gene Name

• CACNB1

Ensembl ID

• ENST00000344140
• ENSP00000345461
• ENSG00000067191
• ENST00000394303
• ENSP00000377840
• ENST00000394310
• ENSP00000377847

Symbol

• CACNLB1
• CAB1
• CCHLB1
• CACNLB1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	0.91
molecular function	0.79
co-expressed gene	0.76
virus perturbation	0.76
protein domain	0.73

Protein Classes

PANTHER Classes

Protein / Transporter / Ion Channel / Voltage-gated Ion Channel / Voltage-gated Calcium Channel / Voltage-dependent L-type Calcium Channel Subunit Beta-1

Protein / Transporter / Ion Channel / Calcium Channel / Voltage-gated Calcium Channel / Voltage-dependent L-type Calcium Channel Subunit Beta-1

DTO Classes

Protein / Ion Channel / Calcium Channel Auxiliary Subunit Types 1-4 (Cca-) Family / Voltage-dependent L-type Calcium Channel Subunit Beta-1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.61   (req: < 5)

Gene RIFs: 4   (req: <= 3)

Antibodies: 370   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.61   (req: >= 5)

Gene RIFs: 4   (req: > 3)

Antibodies: 370   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0