You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
PAX5
Paired box protein Pax-5

Protein Summary
Description
May play an important role in B-cell differentiation as well as neural development and spermatogenesis. Involved in the regulation of the CD19 gene, a B-lymphoid-specific target gene. This gene encodes a member of the paired box (PAX) family of transcription factors. The central feature of this gene family is a novel, highly conserved DNA-binding motif, known as the paired box. Paired box transcription factors are important regulators in early development, and alterations in the expression of their genes are thought to contribute to neoplastic transformation. This gene encodes the B-cell lineage specific activator protein that is expressed at early, but not late stages of B-cell differentiation. Its expression has also been detected in developing CNS and testis and so the encoded protein may also play a role in neural development and spermatogenesis. This gene is located at 9p13, which is involved in t(9;14)(p13;q32) translocations recurring in small lymphocytic lymphomas of the plasma ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000358127
  • ENSP00000350844
  • ENSG00000196092
  • ENST00000377840
  • ENSP00000367071
  • ENST00000377847
  • ENSP00000367078
  • ENST00000377852
  • ENSP00000367083
  • ENST00000377853
  • ENSP00000367084
  • ENST00000414447
  • ENSP00000412188
  • ENST00000446742
  • ENSP00000404687
  • ENST00000520281
  • ENSP00000430773
  • ENST00000523493
  • ENSP00000431038

Symbol
  • ALL3
  • BSAP
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.85
biological term
0.84
cell type or tissue
0.81
molecular function
0.79
PubMedID
0.78


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 797.04   (req: < 5)
Gene RIFs: 124   (req: <= 3)
Antibodies: 841   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 797.04   (req: >= 5)
Gene RIFs: 124   (req: > 3)
Antibodies: 841   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
unipolar depression
2
2
1
1
98.7
wellbeing measurement
3
2
3
72.1
chronotype measurement
1
2
2
62.6
depressive symptom measurement
1
1
1
53.6
neuroticism measurement
1
1
1
52.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
unipolar depression
1
1
98.7
wellbeing measurement
3
72.1
chronotype measurement
2
62.6
depressive symptom measurement
1
53.6
neuroticism measurement
1
52.5
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
paired box 5
VGNC:13933
747452
Macaque
paired box 5
716839
Mouse
MGI:97489
18507
Rat
RGD:1565236
500453
Dog
paired box 5
VGNC:44278
612021
Species
Name
OMA
EggNOG
Inparanoid
Chimp
paired box 5
Macaque
paired box 5
Mouse
Rat
Dog
paired box 5
Protein Data Bank (2)
1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (57)
Gene expression (Transcription) (R-HSA-74160)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
RNA Polymerase II Transcription
Reactome
RUNX1 regulates transcription of genes involved in BCR signaling
Reactome
Transcriptional regulation by RUNX1
Name
Explore in Pharos
Explore in Source
Gene expression (Transcription)
Generic Transcription Pathway
RNA Polymerase II Transcription
RUNX1 regulates transcription of genes involved in BCR signaling
Transcriptional regulation by RUNX1
Gene Ontology Terms (21)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Sequence Alignment (ISA)
NTNU_SB
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (190)
1 – 10 of 190
ETS1
Tbio
Family: TF
Novelty: 0.00105233
Score: 0.988
Data Source: STRINGDB
MYB
Tbio
Family: TF
Novelty: 0.00092053
Score: 0.97
Data Source: STRINGDB
LEF1
Tchem
Family: TF
Novelty: 0.00168638
Score: 0.964
Data Source: STRINGDB
EBF1
Tbio
Family: TF
Novelty: 0.00445405
Score: 0.963
Data Source: STRINGDB
RUNX1
Tbio
Family: TF
Novelty: 0.0085181
Score: 0.952
Data Source: Reactome,STRINGDB
PRDM1
Tbio
Family: TF; Epigenetic
Novelty: 0.00224931
Score: 0.946
Data Source: STRINGDB
BLK
Tchem
Family: Kinase
Novelty: 0.00480349
Score: 0.939
Data Source: STRINGDB
CBFB
Tchem
Family: TF
Novelty: 0.04825679
Score: 0.91
Data Source: Reactome,STRINGDB
ELF2
Tbio
Family: TF
Novelty: 0.01302604
Score: 0.907
Data Source: STRINGDB
ELF1
Tbio
Family: TF
Novelty: 0.10888716
Score: 0.9
Data Source: STRINGDB
Publication Statistics
PubMed Score  797.04

PubMed score by year
PubTator Score  2075.58

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by: