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Tbio
RPL18A
60S ribosomal protein L18a

Protein Summary
Description
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a member of the L18AE family of ribosomal proteins that is a component of the 60S subunit. The encoded protein may play a role in viral replication by interacting with the hepatitis C virus internal ribosome entry site (IRES). This gene is co-transcribed with the U68 snoRNA, located within the third intron. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed throughout the genome. [provided by RefSeq, Jul 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000222247
  • ENSP00000222247
  • ENSG00000105640

Symbol
  • L18A
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
1
hub protein
0.99
small molecule perturbation
0.99
kinase perturbation
0.98
transcription factor binding site profile
0.88


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.7   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 135   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.7   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 135   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte measurement
2
3
3
78.4
reticulocyte count
1
2
2
68.4
cancer antigen 19.9 measurement
1
1
1
57.8
cancer biomarker measurement
1
1
1
14.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte measurement
3
78.4
reticulocyte count
2
68.4
cancer antigen 19.9 measurement
1
57.8
cancer biomarker measurement
1
14.1
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ribosomal protein L18a
VGNC:12078
748555
Macaque
ribosomal protein L18a
719242
Mouse
MGI:1924058
76808
Rat
RGD:1302976
290641
Dog
ribosomal protein L18a
476672
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ribosomal protein L18a
Macaque
ribosomal protein L18a
Mouse
Rat
Dog
ribosomal protein L18a
Protein Structure (6 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q02543-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 6
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (34)
Axon guidance (R-HSA-422475)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 32
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Axon guidance
Reactome
Cap-dependent Translation Initiation
Reactome
Developmental Biology
Reactome
Disease
Reactome
Eukaryotic Translation Elongation
Name
Explore in Pharos
Explore in Source
Axon guidance
Cap-dependent Translation Initiation
Developmental Biology
Disease
Eukaryotic Translation Elongation
Gene Ontology Terms (13)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Traceable Author Statement (TAS)
ProtInc
Protein-Protein Interactions (509)
1 – 10 of 509
PUM3
Tbio
Novelty:  0.02344206
p_int:  0.99901895
p_ni:  0.00098105
Score:  0.539
Data Source:  BioPlex,STRINGDB
TAF1D
Tdark
Family:  Enzyme
Novelty:  0.26072519
p_int:  0.996277917
p_ni:  0.003722081
p_wrong:  2e-9
Score:  0.296
Data Source:  BioPlex,STRINGDB
TSPYL2
Tbio
Novelty:  0.03720016
p_int:  0.995494695
p_ni:  0.004503972
p_wrong:  0.000001332
Score:  0.22
Data Source:  BioPlex,STRINGDB
PDCD11
Tbio
Novelty:  0.02209612
p_int:  0.995399863
p_ni:  0.004600137
Score:  0.293
Data Source:  BioPlex,STRINGDB
RRP8
Tbio
Family:  Enzyme
Novelty:  0.04922797
p_int:  0.993285283
p_ni:  0.006714717
Score:  0.383
Data Source:  BioPlex,STRINGDB
CENPU
Tbio
Novelty:  0.03681625
p_int:  0.992565351
p_ni:  0.007434649
Score:  0.23
Data Source:  BioPlex,STRINGDB
NOC2L
Tbio
Novelty:  0.00226536
p_int:  0.992145165
p_ni:  0.007854835
Score:  0.515
Data Source:  BioPlex,STRINGDB
URB1
Tbio
Novelty:  0.04246076
p_int:  0.991437578
p_ni:  0.008562422
Score:  0.173
Data Source:  BioPlex,STRINGDB
DDX24
Tbio
Family:  Enzyme
Novelty:  0.17803446
p_int:  0.991098226
p_ni:  0.008901774
Score:  0.422
Data Source:  BioPlex,STRINGDB
CEBPZ
Tbio
Novelty:  0.00861664
p_int:  0.988081556
p_ni:  0.011918438
p_wrong:  6e-9
Score:  0.216
Data Source:  BioPlex,STRINGDB
Publication Statistics
PubMed Score  19.70

PubMed score by year
PubTator Score  2.22

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer