Tbio ID3 DNA-binding protein inhibitor ID-3

Protein Summary

Description

Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. Implicated in regulating a variety of cellular processes, including cellular growth, senescence, differentiation, apoptosis, angiogenesis, and neoplastic transformation. Involved in myogenesis by inhibiting skeletal muscle and cardiac myocyte differentiation and promoting muscle precursor cells proliferation. Inhibits the binding of E2A-containing protein complexes to muscle creatine kinase E-box enhancer. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer. The protein encoded by this gene is a helix-loop-helix (HLH) protein that can form heterodimers with other HLH proteins. However, the encoded protein lacks a basic DNA-binding domain and therefore inhibits the DNA binding of any HLH protein with which it interacts. [provided by RefSeq, Aug 2011]

Uniprot Accession IDs

• Q02535
• A8K1T8
• O75641

Gene Name

• ID3

Ensembl ID

• ENST00000374561
• ENSP00000363689
• ENSG00000117318
• ENST00000634790
• ENSP00000489102
• ENSG00000283060

Symbol

• 1R21
• BHLHB25
• HEIR1
• HEIR-1
• bHLHb25

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
PubMedID	1
gene perturbation	0.99
transcription factor perturbation	0.96
kinase perturbation	0.93
small molecule perturbation	0.93

Protein Classes

PANTHER Classes

Protein / Transcription Factor / Dna-binding Protein Inhibitor Id-3

DTO Classes

Protein / Transcription Factor / Dna-binding Protein Inhibitor Id-3

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 675.8   (req: < 5)

Gene RIFs: 76   (req: <= 3)

Antibodies: 541   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 675.8   (req: >= 5)

Gene RIFs: 76   (req: > 3)

Antibodies: 541   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 31

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0