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Tbio
MUC3A
Mucin-3A

Protein Summary
Description
Major glycoprotein component of a variety of mucus gels. Thought to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces. May be involved in ligand binding and intracellular signaling. The mucin genes encode epithelial glycoproteins, some of which are secreted and some membrane bound. Each of the genes contains at least one large domain of tandemly repeated sequence that encodes the peptide sequence rich in serine and/or threonine residues, which carries most of the O-linked glycosylation (Gendler and Spicer, 1995 [PubMed 7778880]).[supplied by OMIM, Aug 2008]
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.67
interacting protein
0.61
small molecule perturbation
0.61
cellular component
0.58
cell line
0.52


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.47   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 0   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.47   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 0   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (17)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
6
3
6
96.5
hair color
1
2
0
1.4
90.9
heart rate response to recovery post exercise
5
2
5
81.2
alkaline phosphatase measurement
2
2
1
6.8
75.7
heel bone mineral density
2
2
2
57.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
6
96.5
hair color
0
1.4
90.9
heart rate response to recovery post exercise
5
81.2
alkaline phosphatase measurement
1
6.8
75.7
heel bone mineral density
2
57.7
Protein Structure (0 Structures, 11 AlphaFold Models)
RepresentationColor Scheme

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (15)
C-type lectin receptors (CLRs) (R-HSA-5621481)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 15
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
C-type lectin receptors (CLRs)
Reactome
Dectin-2 family
Reactome
Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS)
Reactome
Defective GALNT12 causes colorectal cancer 1 (CRCS1)
Reactome
Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC)
Name
Explore in Pharos
Explore in Source
C-type lectin receptors (CLRs)
Dectin-2 family
Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS)
Defective GALNT12 causes colorectal cancer 1 (CRCS1)
Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC)
Protein-Protein Interactions (83)
1 – 10 of 83
MUC13
Tbio
Novelty:  0.01282861
Score:  0.974
Data Source:  STRINGDB
MUC15
Tbio
Novelty:  0.02213624
Score:  0.971
Data Source:  STRINGDB
MUC5B
Tbio
Novelty:  0.000832
Score:  0.97
Data Source:  STRINGDB
GALNT13
Tbio
Family:  Enzyme
Novelty:  0.12592259
Score:  0.969
Data Source:  STRINGDB
MUC7
Tbio
Novelty:  0.00750654
Score:  0.969
Data Source:  STRINGDB
MUC6
Tbio
Novelty:  0.00304872
Score:  0.969
Data Source:  STRINGDB
MUC20
Tbio
Novelty:  0.04645313
Score:  0.969
Data Source:  STRINGDB
MUC16
Tbio
Novelty:  0.00444587
Score:  0.967
Data Source:  STRINGDB
MUC5AC
Tbio
Novelty:  0.00074159
Score:  0.966
Data Source:  STRINGDB
MUC21
Tbio
Novelty:  0.02583488
Score:  0.966
Data Source:  STRINGDB
Publication Statistics
PubMed Score  17.47

PubMed score by year
PubTator Score  8.56

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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