Tbio MUC3A Mucin-3A

Protein Summary

Description

Major glycoprotein component of a variety of mucus gels. Thought to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces. May be involved in ligand binding and intracellular signaling. The mucin genes encode epithelial glycoproteins, some of which are secreted and some membrane bound. Each of the genes contains at least one large domain of tandemly repeated sequence that encodes the peptide sequence rich in serine and/or threonine residues, which carries most of the O-linked glycosylation (Gendler and Spicer, 1995 [PubMed 7778880]).[supplied by OMIM, Aug 2008]

Uniprot Accession IDs

• Q02505
• A6NP22
• O14650
• O14651
• O43418
• O43421
• Q02506
• Q6W763
• Q9H3Q7
• Q9UKW9
• Q9UN93
• Q9UN94
• Q9UN95
• MUC-3A

Gene Name

• MUC3A

Ensembl ID

• ENST00000379458
• ENSP00000368771
• ENSG00000169894
• ENST00000483366
• ENSP00000483541

Symbol

• MUC3
• MUC3
• MUC-3A

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
cell type or tissue	0.67
interacting protein	0.61
small molecule perturbation	0.61
cellular component	0.58
cell line	0.52

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.47   (req: < 5)

Gene RIFs: 9   (req: <= 3)

Antibodies: 0   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.47   (req: >= 5)

Gene RIFs: 9   (req: > 3)

Antibodies: 0   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

GWAS Traits (17)

• Explore on Target Illumination GWAS Analytics (TIGA)

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1 – 5 of 17

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
sex hormone-binding globulin measurement	EFO_0004696	6	3	6		96.5
hair color	EFO_0003924	1	2	0	1.4	90.9
heart rate response to recovery post exercise	EFO_0009185	5	2	5		81.2
alkaline phosphatase measurement	EFO_0004533	2	2	1	6.8	75.7
heel bone mineral density	EFO_0009270	2	2	2		57.7

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 5 of 17

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
sex hormone-binding globulin measurement	EFO_0004696	6		96.5
hair color	EFO_0003924	0	1.4	90.9
heart rate response to recovery post exercise	EFO_0009185	5		81.2
alkaline phosphatase measurement	EFO_0004533	1	6.8	75.7
heel bone mineral density	EFO_0009270	2		57.7

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Protein Structure (0 Structures, 11 AlphaFold Models)

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Representation

  axes   backbone   ball+stick   cartoon   rocket   rope   spacefill

Color Scheme

  target   atomindex   bfactor   chainname   electrostatic   element   hydrophobicity   resname   sstruc

AF-Q02505-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (15)

Reactome (15)

C-type lectin receptors (CLRs) (R-HSA-5621481)

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	C-type lectin receptors (CLRs)	144 targets	R-HSA-5621481
Reactome	Dectin-2 family	29 targets	R-HSA-5621480
Reactome	Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS)	20 targets	R-HSA-5083632
Reactome	Defective GALNT12 causes colorectal cancer 1 (CRCS1)	19 targets	R-HSA-5083636
Reactome	Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC)	19 targets	R-HSA-5083625

Name	Explore in Pharos	Explore in Source
C-type lectin receptors (CLRs)	144 targets	R-HSA-5621481
Dectin-2 family	29 targets	R-HSA-5621480
Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS)	20 targets	R-HSA-5083632
Defective GALNT12 causes colorectal cancer 1 (CRCS1)	19 targets	R-HSA-5083636
Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC)	19 targets	R-HSA-5083625

Gene Ontology Terms (8)

Functions (2)

Components (4)

Processes (2)

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1 – 2 of 2

GO Term	Evidence	Assigned by
extracellular matrix constituent, lubricant activity	Non-traceable Author Statement (NAS)	UniProtKB
extracellular matrix structural constituent	Non-traceable Author Statement (NAS)	UniProtKB

Protein-Protein Interactions (83)

Explore Interacting Targets

1 – 10 of 83

• See Interactions on String-DB

MUC13

Tbio

Novelty:  0.01282861

Score:  0.974

Data Source:  STRINGDB

MUC15

Tbio

Novelty:  0.02213624

Score:  0.971

Data Source:  STRINGDB

MUC5B

Tbio

Novelty:  0.000832

Score:  0.97

Data Source:  STRINGDB

GALNT13

Tbio

Family:  Enzyme

Novelty:  0.12592259

Score:  0.969

Data Source:  STRINGDB

MUC7

Tbio

Novelty:  0.00750654

Score:  0.969

Data Source:  STRINGDB

MUC6

Tbio

Novelty:  0.00304872

Score:  0.969

Data Source:  STRINGDB

MUC20

Tbio

Novelty:  0.04645313

Score:  0.969

Data Source:  STRINGDB

MUC16

Tbio

Novelty:  0.00444587

Score:  0.967

Data Source:  STRINGDB

MUC5AC

Tbio

Novelty:  0.00074159

Score:  0.966

Data Source:  STRINGDB

MUC21

Tbio

Novelty:  0.02583488

Score:  0.966

Data Source:  STRINGDB

Publication Statistics

PubMed Score  17.47

PubMed score by year

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PubTator Score  8.56

PubTator score by year

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Amino Acid Sequence

Residue Counts

Protein Sequence

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UniProt Keyword Find Similar Targets

No Header	No Header
Alternative splicing
Complete proteome
Disulfide bond
EGF-like domain
Glycoprotein
Membrane
Polymorphism
Reference proteome
Repeat
Secreted

GWAS Trait Find Similar Targets

No Header	No Header
alkaline phosphatase measurement
apolipoprotein A 1 measurement
body mass index
chronic kidney disease
electrocardiography
hair color
heart rate
heart rate response to exercise
heart rate response to recovery post exercise
heel bone mineral density

MGI Phenotype Find Similar Targets

No Header	No Header
integument phenotype