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Tbio
SP3
Transcription factor Sp3

Protein Summary
Description
Transcriptional factor that can act as an activator or repressor depending on isoform and/or post-translational modifications. Binds to GT and GC boxes promoter elements. Competes with SP1 for the GC-box promoters. Weak activator of transcription but can activate a number of genes involved in different processes such as cell-cycle regulation, hormone-induction and house-keeping. This gene belongs to a family of Sp1 related genes that encode transcription factors that regulate transcription by binding to consensus GC- and GT-box regulatory elements in target genes. This protein contains a zinc finger DNA-binding domain and several transactivation domains, and has been reported to function as a bifunctional transcription factor that either stimulates or represses the transcription of numerous genes. Transcript variants encoding different isoforms have been described for this gene, and one has been reported to initiate translation from a non-AUG (AUA) start codon. Additional isoforms, res ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000310015
  • ENSP00000310301
  • ENSG00000172845
  • ENST00000640958
  • ENSP00000492253

Symbol
  • SPR2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.95
transcription factor binding site profile
0.95
biological process
0.9
virus perturbation
0.88
hub protein
0.85


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 774.59   (req: < 5)
Gene RIFs: 138   (req: <= 3)
Antibodies: 380   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 774.59   (req: >= 5)
Gene RIFs: 138   (req: > 3)
Antibodies: 380   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 28
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
1.1
63.9
appendicular lean mass
1
1
1
59.8
red blood cell distribution width
2
1
2
43.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
63.9
appendicular lean mass
1
59.8
red blood cell distribution width
2
43.5
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
Sp3 transcription factor
VGNC:2817
459750
Macaque
Sp3 transcription factor
699901
Mouse
MGI:1277166
20687
Rat
RGD:1583765
367846
Dog
Sp3 transcription factor
VGNC:53107
488405
Species
Name
OMA
EggNOG
Inparanoid
Chimp
Sp3 transcription factor
Macaque
Sp3 transcription factor
Mouse
Rat
Dog
Sp3 transcription factor
Pathways (13)
Metabolism of proteins (R-HSA-392499)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of proteins
Reactome
Post-translational protein modification
Reactome
SUMO E3 ligases SUMOylate target proteins
Reactome
SUMOylation
Reactome
SUMOylation of transcription factors
Name
Explore in Pharos
Explore in Source
Metabolism of proteins
Post-translational protein modification
SUMO E3 ligases SUMOylate target proteins
SUMOylation
SUMOylation of transcription factors
Gene Ontology Terms (33)
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
ARUK-UCL
Inferred from Sequence Alignment (ISA)
NTNU_SB
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (74)
1 – 10 of 74
SGCZ
Tbio
Novelty: 0.08511312
p_int: 0.999900626
p_ni: 0.000099356
p_wrong: 1.8e-8
Score: 0.297
Data Source: BioPlex,STRINGDB
ADAM18
Tdark
Family: Enzyme
Novelty: 0.22622379
p_int: 0.996562807
p_ni: 0.003317753
p_wrong: 0.000119441
Data Source: BioPlex
PDGFRL
Tbio
Novelty: 0.0709225
p_int: 0.971842102
p_ni: 0.028109521
p_wrong: 0.000048376
Data Source: BioPlex
TSHB
Tbio
Novelty: 0.00194403
p_int: 0.942704118
p_ni: 0.038813955
p_wrong: 0.018481928
Score: 0.381
Data Source: BioPlex,STRINGDB
MBTPS1
Tchem
Family: Enzyme
Novelty: 0.00845881
p_int: 0.862285858
p_ni: 0.137681606
p_wrong: 0.000032535
Data Source: BioPlex
HDAC2
Tclin
Family: Epigenetic
Novelty: 0.0011024
Score: 0.96
Data Source: STRINGDB
SUMO1
Tbio
Novelty: 0.00137629
Score: 0.959
Data Source: Reactome,STRINGDB
SP1
Tbio
Family: TF
Novelty: 0.0007915
Score: 0.952
Data Source: STRINGDB
CDKN1A
Tbio
Family: Enzyme
Novelty: 0.00033009
Score: 0.952
Data Source: STRINGDB
UBE2I
Tbio
Novelty: 0.00267883
Score: 0.951
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score  774.59

PubMed score by year
PubTator Score  790.74

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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