Tbio SP3 Transcription factor Sp3

Protein Summary

Description

Transcriptional factor that can act as an activator or repressor depending on isoform and/or post-translational modifications. Binds to GT and GC boxes promoter elements. Competes with SP1 for the GC-box promoters. Weak activator of transcription but can activate a number of genes involved in different processes such as cell-cycle regulation, hormone-induction and house-keeping. This gene belongs to a family of Sp1 related genes that encode transcription factors that regulate transcription by binding to consensus GC- and GT-box regulatory elements in target genes. This protein contains a zinc finger DNA-binding domain and several transactivation domains, and has been reported to function as a bifunctional transcription factor that either stimulates or represses the transcription of numerous genes. Transcript variants encoding different isoforms have been described for this gene, and one has been reported to initiate translation from a non-AUG (AUA) start codon. Additional isoforms, resulting from the use of alternate downstream translation initiation sites, have also been noted. A related pseudogene has been identified on chromosome 13. [provided by RefSeq, Feb 2010]

Uniprot Accession IDs

• Q02447
• A0AVL9
• B4E2B7
• Q69B26
• Q69B27
• Q8TD56
• Q8WWU4
• Q9BQR1

Gene Name

• SP3

Ensembl ID

• ENST00000310015
• ENSP00000310301
• ENSG00000172845
• ENST00000640958
• ENSP00000492253

Symbol

• SPR2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.95
transcription factor binding site profile	0.95
biological process	0.9
virus perturbation	0.88
hub protein	0.85

Protein Classes

PANTHER Classes

Protein / Transcription Factor / Zinc Finger Transcription Factor / Transcription Factor Sp3

Protein / Transcription Factor / Transcription Cofactor / Transcription Factor Sp3

Protein / Nucleic Acid Binding / Dna Binding Protein / Transcription Factor Sp3

DTO Classes

Protein / Nucleic Acid Binding / Dna Binding Protein / Transcription Factor Sp3

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1082.15   (req: < 5)

Gene RIFs: 144   (req: <= 3)

Antibodies: 380   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1082.15   (req: >= 5)

Gene RIFs: 144   (req: > 3)

Antibodies: 380   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 28

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0