Tbio DSG1 Desmoglein-1

Protein Summary

Description

Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. This gene encodes a member of the desmoglein protein subfamily. Desmogleins, along with desmocollins, are cadherin-like transmembrane glycoproteins that are major components of the desmosome. Desmosomes are cell-cell junctions that help resist shearing forces and are found in high concentrations in cells subject to mechanical stress. This gene is found in a cluster with other desmoglein family members on chromosome 18. The encoded protein has been identified as a target of auto-antibodies in the autoimmune skin blistering disease pemphigus foliaceus. Disruption of this gene has also been associated with the skin diseases palmoplantar keratoderma and erythroderma. [provided by RefSeq, Feb 2015]

Uniprot Accession IDs

• Q02413
• B7Z845

Gene Name

• DSG1

Ensembl ID

• ENST00000257192
• ENSP00000257192
• ENSG00000134760
• ENST00000462981
• ENSP00000462666

Symbol

• CDHF4
• DG1
• DSG
• CDHF4
• EPKHE
• PPKS1
• SPPK1
• EPKHIA

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein complex	1
interacting protein	0.98
protein domain	0.92
gene perturbation	0.76
cellular component	0.74

Protein Classes

PANTHER Classes

Protein / Cell Junction Protein / Desmoglein-1

Protein / Cell Adhesion Molecule / Cadherin / Desmoglein-1

DTO Classes

Protein / Cell Adhesion / Cadherin / Desmoglein-1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 863.28   (req: < 5)

Gene RIFs: 71   (req: <= 3)

Antibodies: 733   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 863.28   (req: >= 5)

Gene RIFs: 71   (req: > 3)

Antibodies: 733   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0