You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
DSG1
Desmoglein-1

Protein Summary
Description
Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. This gene encodes a member of the desmoglein protein subfamily. Desmogleins, along with desmocollins, are cadherin-like transmembrane glycoproteins that are major components of the desmosome. Desmosomes are cell-cell junctions that help resist shearing forces and are found in high concentrations in cells subject to mechanical stress. This gene is found in a cluster with other desmoglein family members on chromosome 18. The encoded protein has been identified as a target of auto-antibodies in the autoimmune skin blistering disease pemphigus foliaceus. Disruption of this gene has also been associated with the skin diseases palmoplantar keratoderma and erythroderma. [provided by RefSeq, Feb 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000257192
  • ENSP00000257192
  • ENSG00000134760
  • ENST00000462981
  • ENSP00000462666

Symbol
  • CDHF4
  • DG1
  • DSG
  • CDHF4
  • EPKHE
  • PPKS1
  • SPPK1
  • EPKHIA
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein complex
1
interacting protein
0.98
protein domain
0.92
gene perturbation
0.76
cellular component
0.74


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 863.28   (req: < 5)
Gene RIFs: 55   (req: <= 3)
Antibodies: 733   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 863.28   (req: >= 5)
Gene RIFs: 55   (req: > 3)
Antibodies: 733   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (112)
CCDC51
Tdark
Novelty:  1.19203634
p_int:  0.936203192
p_ni:  0.063796808
Score:  0.175
Data Source:  BioPlex,STRINGDB
PI4KA
Tchem
Family:  Kinase
Novelty:  0.01701469
p_int:  0.904551138
p_ni:  0.095448862
Data Source:  BioPlex
TBC1D22B
Tbio
Novelty:  0.49852962
p_int:  0.869865587
p_ni:  0.130134413
Data Source:  BioPlex
VAV1
Tchem
Novelty:  0.00180518
p_int:  0.828215187
p_ni:  0.171784813
Score:  0.221
Data Source:  BioPlex,STRINGDB
CFAP298
Tbio
Novelty:  0.1550579
p_int:  0.819776528
p_ni:  0.180223471
Score:  0.161
Data Source:  BioPlex,STRINGDB
PKP1
Tbio
Novelty:  0.0100609
Score:  0.993
Data Source:  STRINGDB
PKP2
Tbio
Novelty:  0.00493803
Score:  0.992
Data Source:  STRINGDB
DSP
Tbio
Novelty:  0.00178018
Score:  0.992
Data Source:  STRINGDB
PKP3
Tbio
Novelty:  0.0269462
Score:  0.991
Data Source:  STRINGDB
JUP
Tbio
Novelty:  0.0081803
Score:  0.985
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (19)
Apoptosis (R-HSA-109581)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 11
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Apoptosis
Reactome
Apoptotic cleavage of cell adhesion proteins
Reactome
Apoptotic cleavage of cellular proteins
Reactome
Apoptotic execution phase
Reactome
Developmental Biology
Name
Explore in Pharos
Explore in Source
Apoptosis
Apoptotic cleavage of cell adhesion proteins
Apoptotic cleavage of cellular proteins
Apoptotic execution phase
Developmental Biology
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood protein measurement
1
1
0
1
73.5
vitamin D measurement
3
2
3
72.2
susceptibility to vaginal yeast infection measurement
1
1
1
70.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood protein measurement
0
1
73.5
vitamin D measurement
3
72.2
susceptibility to vaginal yeast infection measurement
1
70.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
desmoglein 1
VGNC:5158
468510
Macaque
desmoglein 1
705452
Mouse
MGI:94930
13510
Rat
RGD:1309925
291755
Dog
desmoglein 1
VGNC:40105
403401
Species
Name
OMA
EggNOG
Inparanoid
Chimp
desmoglein 1
Macaque
desmoglein 1
Mouse
Rat
Dog
desmoglein 1
Publication Statistics
PubMed Score 863.28
PubMed score by year
PubTator Score 526.20
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title