You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
ID2
DNA-binding protein inhibitor ID-2

Protein Classes
PANTHER Classes Protein / Transcription Factor / Dna-binding Protein Inhibitor Id-2
Protein Summary
Description
Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. Implicated in regulating a variety of cellular processes, including cellular growth, senescence, differentiation, apoptosis, angiogenesis, and neoplastic transformation. Inhibits skeletal muscle and cardiac myocyte differentiation. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer. Restricts the CLOCK and ARNTL/BMAL1 localization to the cytoplasm. Plays a role in both the input and output pathways of the circadian clock: in the input component, is involved in modulating the magnitude of photic entrainment and in the output component, contributes to the regulation of a variety of liver clock-controlled genes involved in lipid metabolism. The protein encoded by this gene belongs to the inhi ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000234091
  • ENSP00000234091
  • ENSG00000115738
  • ENST00000331129
  • ENSP00000385465
  • ENST00000396290
  • ENSP00000379585

Symbol
  • BHLHB26
  • GIG8
  • ID2A
  • ID2H
  • bHLHb26
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
gene perturbation
1
PubMedID
1
transcription factor perturbation
1
kinase perturbation
0.96


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 321.95   (req: < 5)
View Publications
Gene RIFs: 92   (req: <= 3)
View Gene RIFs
Antibodies: 399   (req: <= 50)
View Antibodies
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 321.95   (req: >= 5)
Gene RIFs: 92   (req: > 3)
Antibodies: 399   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 57
View GO Terms
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (19)
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
KEGG
TGF-beta signaling pathway
93 targets
path:hsa04350
KEGG
Signaling pathways regulating pluripotency of stem cells
139 targets
path:hsa04550
KEGG
Hippo signaling pathway
154 targets
path:hsa04390
KEGG
Transcriptional misregulation in cancer
172 targets
path:hsa05202
Name
Explore in Pharos
Explore in Source
TGF-beta signaling pathway
93 targets
path:hsa04350
Signaling pathways regulating pluripotency of stem cells
139 targets
path:hsa04550
Hippo signaling pathway
154 targets
path:hsa04390
Transcriptional misregulation in cancer
172 targets
path:hsa05202
Gene Ontology Terms (61)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
ion channel binding
Inferred from Physical Interaction (IPI)
BHF-UCL
DNA-binding transcription factor activity
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
RNA polymerase II transcription factor binding
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
transcription factor binding
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
DNA-binding transcription factor activity, RNA polymerase II-specific
Inferred from Sequence Model (ISM)
NTNU_SB
protein dimerization activity
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (168)
1 – 10 of 168
TCF3
Tbio
Family: TF
Novelty: 0.00154157
p_int: 0.999999936
p_ni: 6.4e-8
Score: 0.881
Data Source: BioPlex,STRINGDB
TCF4
Tbio
Family: TF
Novelty: 0.00249816
p_int: 0.999999882
p_ni: 1.18e-7
Score: 0.89
Data Source: BioPlex,STRINGDB
TCF12
Tbio
Family: TF
Novelty: 0.00546341
p_int: 0.999997212
p_ni: 0.000002788
Score: 0.831
Data Source: BioPlex,STRINGDB
ID4
Tbio
Family: TF
Novelty: 0.00570969
p_int: 0.99994069
p_ni: 0.000057752
p_wrong: 0.000001558
Score: 0.703
Data Source: BioPlex,STRINGDB
PHF3
Tbio
Family: Epigenetic
Novelty: 0.07141035
p_int: 0.999518134
p_ni: 0.000481855
p_wrong: 1.2e-8
Score: 0.219
Data Source: BioPlex,STRINGDB
WBP11
Tbio
Novelty: 0.06200904
p_int: 0.994659898
p_ni: 0.005323416
p_wrong: 0.000016686
Score: 0.177
Data Source: BioPlex,STRINGDB
CLASP2
Tbio
Novelty: 0.04153995
p_int: 0.994144077
p_ni: 0.004588968
p_wrong: 0.001266954
Score: 0.181
Data Source: BioPlex,STRINGDB
YY1
Tbio
Family: TF
Novelty: 0.00149355
p_int: 0.981985099
p_ni: 0.011023875
p_wrong: 0.006991026
Score: 0.38
Data Source: BioPlex,STRINGDB
ZGPAT
Tbio
Family: Epigenetic
Novelty: 0.3373494
p_int: 0.959393717
p_ni: 0.040311538
p_wrong: 0.000294744
Data Source: BioPlex
MACF1
Tbio
Novelty: 0.01315618
p_int: 0.958664885
p_ni: 0.041335115
Score: 0.177
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  321.95

PubMed score by year
PubTator Score  262.26

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by: