Tbio ID2 DNA-binding protein inhibitor ID-2

Protein Summary

Description

Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. Implicated in regulating a variety of cellular processes, including cellular growth, senescence, differentiation, apoptosis, angiogenesis, and neoplastic transformation. Inhibits skeletal muscle and cardiac myocyte differentiation. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer. Restricts the CLOCK and ARNTL/BMAL1 localization to the cytoplasm. Plays a role in both the input and output pathways of the circadian clock: in the input component, is involved in modulating the magnitude of photic entrainment and in the output component, contributes to the regulation of a variety of liver clock-controlled genes involved in lipid metabolism. The protein encoded by this gene belongs to the inhibitor of DNA binding family, members of which are transcriptional regulators that contain a helix-loop-helix (HLH) domain but not a basic domain. Members of the inhibitor of DNA binding family inhibit the functions of basic helix-loop-helix transcription factors in a dominant-negative manner by suppressing their heterodimerization partners through the HLH domains. This protein may play a role in negatively regulating cell differentiation. A pseudogene of this gene is located on chromosome 3. [provided by RefSeq, Aug 2011]

Uniprot Accession IDs

• Q02363

Gene Name

• ID2

Ensembl ID

• ENST00000234091
• ENSP00000234091
• ENSG00000115738
• ENST00000331129
• ENSP00000385465
• ENST00000396290
• ENSP00000379585

Symbol

• BHLHB26
• GIG8
• ID2A
• ID2H
• bHLHb26

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	1
gene perturbation	1
PubMedID	1
transcription factor perturbation	1
kinase perturbation	0.96

Protein Classes

PANTHER Classes

Protein / Transcription Factor / Dna-binding Protein Inhibitor Id-2

DTO Classes

Protein / Transcription Factor / Dna-binding Protein Inhibitor Id-2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 478.28   (req: < 5)

Gene RIFs: 111   (req: <= 3)

Antibodies: 399   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 478.28   (req: >= 5)

Gene RIFs: 111   (req: > 3)

Antibodies: 399   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 57

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0