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Tbio
BDH1
D-beta-hydroxybutyrate dehydrogenase, mitochondrial

Protein Summary
Description
This gene encodes a member of the short-chain dehydrogenase/reductase gene family. The encoded protein forms a homotetrameric lipid-requiring enzyme of the mitochondrial membrane and has a specific requirement for phosphatidylcholine for optimal enzymatic activity. The encoded protein catalyzes the interconversion of acetoacetate and (R)-3-hydroxybutyrate, the two major ketone bodies produced during fatty acid catabolism. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000358186
  • ENSP00000350914
  • ENSG00000161267
  • ENST00000392378
  • ENSP00000376183
  • ENST00000392379
  • ENSP00000376184
  • ENST00000612690
  • ENSP00000484421
  • ENSG00000275544
  • ENST00000617317
  • ENSP00000482744

Symbol
  • BDH
  • SDR9C1
  • BDH
  • SDR9C1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.91
metabolite
0.78
transcription factor perturbation
0.74
virus perturbation
0.72
small molecule perturbation
0.67


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 79.86   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 217   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 79.86   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 217   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
3-hydroxybutyrate dehydrogenase 1
VGNC:53359
460970
Macaque
3-hydroxybutyrate dehydrogenase 1
709490
Mouse
MGI:1919161
71911
Rat
RGD:620131
117099
Dog
3-hydroxybutyrate dehydrogenase 1
VGNC:38422
488037
Species
Name
OMA
EggNOG
Inparanoid
Chimp
3-hydroxybutyrate dehydrogenase 1
Macaque
3-hydroxybutyrate dehydrogenase 1
Mouse
Rat
Dog
3-hydroxybutyrate dehydrogenase 1
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q02338-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (15)
Ketone body metabolism (R-HSA-74182)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Ketone body metabolism
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
Synthesis of Ketone Bodies
Reactome
Utilization of Ketone Bodies
Name
Explore in Pharos
Explore in Source
Ketone body metabolism
Metabolism
Metabolism of lipids
Synthesis of Ketone Bodies
Utilization of Ketone Bodies
Gene Ontology Terms (7)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Protein-Protein Interactions (57)
1 – 10 of 57
LAMP2
Tbio
Novelty: 0.00168009
p_int: 0.980401447
p_ni: 0.019598552
p_wrong: 1e-9
Data Source: BioPlex
APLNR
Tchem
Family: GPCR
Novelty: 0.00224203
p_int: 0.935720385
p_ni: 0.064279615
Data Source: BioPlex
SLC15A1
Tchem
Family: Transporter
Novelty: 0.00149723
p_int: 0.918537526
p_ni: 0.081458254
p_wrong: 0.00000422
Data Source: BioPlex
B3GALT5
Tbio
Family: Enzyme
Novelty: 0.04158039
p_int: 0.913175219
p_ni: 0.086824719
p_wrong: 6.2e-8
Data Source: BioPlex
GLMP
Tdark
Novelty: 0.10163099
p_int: 0.905545828
p_ni: 0.094452189
p_wrong: 0.000001983
Data Source: BioPlex
CMTM8
Tbio
Novelty: 0.0953768
p_int: 0.845567087
p_ni: 0.154429348
p_wrong: 0.000003565
Data Source: BioPlex
SLC39A9
Tbio
Family: Transporter
Novelty: 0.06143625
p_int: 0.831275659
p_ni: 0.168717968
p_wrong: 0.000006373
Data Source: BioPlex
ERGIC3
Tbio
Novelty: 0.11095443
p_int: 0.829068788
p_ni: 0.170931145
p_wrong: 6.7e-8
Data Source: BioPlex
IL13RA2
Tbio
Novelty: 0.03465642
p_int: 0.807671605
p_ni: 0.19232728
p_wrong: 0.000001116
Data Source: BioPlex
TNF
Tclin
Novelty: 0.00001457
p_int: 0.806948777
p_ni: 0.193035555
p_wrong: 0.000015668
Data Source: BioPlex
Publication Statistics
PubMed Score  79.86

PubMed score by year
PubTator Score  51.98

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer