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Tbio
NRG1
Pro-neuregulin-1, membrane-bound isoform

Protein Summary
Description
Direct ligand for ERBB3 and ERBB4 tyrosine kinase receptors. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. The multiple isoforms perform diverse functions such as inducing growth and differentiation of epithelial, glial, neuronal, and skeletal muscle cells; inducing expression of acetylcholine receptor in synaptic vesicles during the formation of the neuromuscular junction; stimulating lobuloalveolar budding and milk production in the mammary gland and inducing differentiation of mammary tumor cells; stimulating Schwann cell proliferation; implication in the development of the myocardium such as trabeculation of the developing heart. Isoform 10 may play a role in motor and sensory neuron development. Binds to ERBB4 (PubMed:10867024, PubMed:7902537). Binds to ERBB3 (PubMed:20682778). Acts as a ligand for integrins and binds (via EGF domain) to integrins ITGAV:ITGB3 or ITGA6:ITGB4. Its bin ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000287842
  • ENSP00000287842
  • ENSG00000157168
  • ENST00000356819
  • ENSP00000349275
  • ENST00000405005
  • ENSP00000384620
  • ENST00000519301
  • ENSP00000429582
  • ENST00000520407
  • ENSP00000434640
  • ENST00000520502
  • ENSP00000433289
  • ENST00000521670
  • ENSP00000428828
  • ENST00000523079
  • ENSP00000430120

Symbol
  • GGF
  • HGL
  • HRGA
  • NDF
  • SMDF
  • GGF
  • HGL
  • HRG
  • NDF
  • ARIA
  • GGF2
  • HRG1
  • HRGA
  • SMDF
  • MST131
  • MSTP131
  • NRG1-IT2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological term
1
trait
1
biological process
0.99
protein domain
0.97
disease
0.87


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1537.18   (req: < 5)
Gene RIFs: 362   (req: <= 3)
Antibodies: 854   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1537.18   (req: >= 5)
Gene RIFs: 362   (req: > 3)
Antibodies: 854   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 69
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0