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Tbio
CNTN2
Contactin-2

Protein Summary
Description
In conjunction with another transmembrane protein, CNTNAP2, contributes to the organization of axonal domains at nodes of Ranvier by maintaining voltage-gated potassium channels at the juxtaparanodal region. May be involved in cell adhesion. This gene encodes a member of the contactin family of proteins, part of the immunoglobulin superfamily of cell adhesion molecules. The encoded glycosylphosphatidylinositol (GPI)-anchored neuronal membrane protein plays a role in the proliferation, migration, and axon guidance of neurons of the developing cerebellum. A mutation in this gene may be associated with adult myoclonic epilepsy. [provided by RefSeq, Sep 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000331830
  • ENSP00000330633
  • ENSG00000184144
  • ENST00000638378
  • ENSP00000492617
  • ENST00000639302
  • ENSP00000491671
  • ENST00000640326
  • ENSP00000492495

Symbol
  • AXT
  • TAG1
  • TAX1
  • AXT
  • TAX
  • TAX1
  • FAME5
  • TAG-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.87
protein domain
0.85
hub protein
0.79
cell type or tissue
0.76
cellular component
0.72


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 495.6   (req: < 5)
Gene RIFs: 13   (req: <= 3)
Antibodies: 250   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 495.6   (req: >= 5)
Gene RIFs: 13   (req: > 3)
Antibodies: 250   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 25
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (26)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
3
4
4
98.5
basophil count
2
2
2
92.1
basophil percentage of leukocytes
2
2
2
90.8
red blood cell density measurement
1
1
1
82.1
risk-taking behaviour
2
3
3
79.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
4
98.5
basophil count
2
92.1
basophil percentage of leukocytes
2
90.8
red blood cell density measurement
1
82.1
risk-taking behaviour
3
79.1
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
contactin 2
VGNC:6115
457662
Macaque
contactin 2
574333
Mouse
MGI:104518
21367
Rat
RGD:3821
25356
Dog
contactin 2
VGNC:39433
100685268
Species
Name
OMA
EggNOG
Inparanoid
Chimp
contactin 2
Macaque
contactin 2
Mouse
Rat
Dog
contactin 2
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q02246-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (7)
Axon guidance (R-HSA-422475)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Axon guidance
Reactome
Developmental Biology
Reactome
L1CAM interactions
Reactome
NCAM signaling for neurite out-growth
Reactome
NCAM1 interactions
Name
Explore in Pharos
Explore in Source
Axon guidance
Developmental Biology
L1CAM interactions
NCAM signaling for neurite out-growth
NCAM1 interactions
Protein-Protein Interactions (221)
1 – 10 of 221
CNTNAP2
Tbio
Novelty:  0.00238905
Score:  0.987
Data Source:  STRINGDB
NRCAM
Tbio
Novelty:  0.00443497
Score:  0.959
Data Source:  Reactome,STRINGDB
L1CAM
Tbio
Novelty:  0.00307041
Score:  0.954
Data Source:  Reactome,STRINGDB
NCAM1
Tbio
Novelty:  0.00020994
Score:  0.948
Data Source:  Reactome,STRINGDB
TAX1BP3
Tbio
Novelty:  0.01605171
Score:  0.927
Data Source:  STRINGDB
LIN7A
Tbio
Novelty:  0.0202389
Score:  0.922
Data Source:  STRINGDB
USH1C
Tbio
Novelty:  0.01066917
Score:  0.902
Data Source:  STRINGDB
NCAN
Tbio
Novelty:  0.00401824
Score:  0.827
Data Source:  STRINGDB
IKBKG
Tbio
Family:  Kinase
Novelty:  0.0006149
Score:  0.761
Data Source:  STRINGDB
PTPRZ1
Tchem
Family:  Enzyme
Novelty:  0.00518159
Score:  0.753
Data Source:  STRINGDB
Publication Statistics
PubMed Score  495.60

PubMed score by year
PubTator Score  1289.74

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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