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Tbio
KIF23
Kinesin-like protein KIF23

Protein Summary
Description
Component of the centralspindlin complex that serves as a microtubule-dependent and Rho-mediated signaling required for the myosin contractile ring formation during the cell cycle cytokinesis. Essential for cytokinesis in Rho-mediated signaling. Required for the localization of ECT2 to the central spindle. Plus-end-directed motor enzyme that moves antiparallel microtubules in vitro. The protein encoded by this gene is a member of kinesin-like protein family. This family includes microtubule-dependent molecular motors that transport organelles within cells and move chromosomes during cell division. This protein has been shown to cross-bridge antiparallel microtubules and drive microtubule movement in vitro. Alternate splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000260363
  • ENSP00000260363
  • ENSG00000137807
  • ENST00000352331
  • ENSP00000304978
  • ENST00000647715
  • ENSP00000497065

Symbol
  • KNSL5
  • MKLP1
  • CHO1
  • KNSL5
  • MKLP1
  • MKLP-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
hub protein
0.98
molecular function
0.98
transcription factor perturbation
0.88
drug perturbation
0.87
histone modification site profile
0.84


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 137.24   (req: < 5)
Gene RIFs: 23   (req: <= 3)
Antibodies: 172   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 137.24   (req: >= 5)
Gene RIFs: 23   (req: > 3)
Antibodies: 172   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean reticulocyte volume
1
1
1
48.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean reticulocyte volume
1
48.8
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
kinesin family member 23
695229
Mouse
MGI:1919069
71819
Rat
RGD:1308596
315740
Dog
kinesin family member 23
478355
Cow
kinesin family member 23
515748
Species
Name
OMA
EggNOG
Inparanoid
Macaque
kinesin family member 23
Mouse
Rat
Dog
kinesin family member 23
Cow
kinesin family member 23
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (17)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 15
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
COPI-dependent Golgi-to-ER retrograde traffic
Reactome
Cell Cycle
Reactome
Cell Cycle, Mitotic
Reactome
Factors involved in megakaryocyte development and platelet production
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
COPI-dependent Golgi-to-ER retrograde traffic
Cell Cycle
Cell Cycle, Mitotic
Factors involved in megakaryocyte development and platelet production
Gene Ontology Terms (26)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (419)
1 – 10 of 419
RACGAP1
Tbio
Family: Enzyme
Novelty: 0.01197099
p_int: 0.999999998
p_ni: 2e-9
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
FAM9B
Tdark
Novelty: 0.39508009
p_int: 0.999260041
p_ni: 0.000739959
Data Source: BioPlex
DMD
Tclin
Novelty: 0.00025661
p_int: 0.999051022
p_ni: 0.000948977
Score: 0.215
Data Source: BioPlex,STRINGDB
APOBEC3D
Tbio
Novelty: 0.01102619
p_int: 0.997715054
p_ni: 0.002284946
Data Source: BioPlex
MEAF6
Tbio
Novelty: 0.0914094
p_int: 0.978951947
p_ni: 0.011531416
p_wrong: 0.009516636
Score: 0.5
Data Source: BioPlex,STRINGDB
RNH1
Tbio
Family: Enzyme
Novelty: 0.00307468
p_int: 0.821550475
p_ni: 0.170517893
p_wrong: 0.007931632
Data Source: BioPlex
PLK1
Tchem
Family: Kinase
Novelty: 0.00062799
Score: 0.999
Data Source: Reactome,STRINGDB
KIF11
Tchem
Novelty: 0.00170673
Score: 0.998
Data Source: STRINGDB
ECT2
Tbio
Novelty: 0.00834186
Score: 0.998
Data Source: STRINGDB
AURKB
Tchem
Family: Kinase
Novelty: 0.00100972
Score: 0.998
Data Source: STRINGDB
Publication Statistics
PubMed Score  137.24

PubMed score by year
PubTator Score  86.49

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer