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Tchem
CENPE
Centromere-associated protein E

Protein Summary
Description
Microtubule plus-end-directed kinetochore motor which plays an important role in chromosome congression, microtubule-kinetochore conjugation and spindle assembly checkpoint activation. Drives chromosome congression (alignment of chromosomes at the spindle equator resulting in the formation of the metaphase plate) by mediating the lateral sliding of polar chromosomes along spindle microtubules towards the spindle equator and by aiding the establishment and maintenance of connections between kinetochores and spindle microtubules (PubMed:7889940, PubMed:23891108, PubMed:25395579). The transport of pole-proximal chromosomes towards the spindle equator is favored by microtubule tracks that are detyrosinated (PubMed:25908662). Acts as a processive bi-directional tracker of dynamic microtubule tips; after chromosomes have congressed, continues to play an active role at kinetochores, enhancing their links with dynamic microtubule ends (PubMed:23955301). Suppresses chromosome congression in NDC ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000265148
  • ENSP00000265148
  • ENSG00000138778
  • ENST00000380026
  • ENSP00000369365

Symbol
  • KIF10
  • CENP-E
  • MCPH13
  • PPP1R61
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.98
histone modification site profile
0.89
biological process
0.83
co-expressed gene
0.82
cellular component
0.79


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 221.25   (req: < 5)
Gene RIFs: 45   (req: <= 3)
Antibodies: 214   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 221.25   (req: >= 5)
Gene RIFs: 45   (req: > 3)
Antibodies: 214   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 22
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 9
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
3
1
0
1.3
84.1
2
2
0
1.3
60.5
testosterone measurement
1
1
1
25.8
1
1
0
1
3.6
triglyceride measurement
1
1
1
2.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.3
84.1
0
1.3
60.5
testosterone measurement
1
25.8
0
1
3.6
triglyceride measurement
1
2.4
Protein Data Bank (2)
1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (31)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 27
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Reactome
Amplification of signal from the kinetochores
Reactome
COPI-dependent Golgi-to-ER retrograde traffic
Reactome
Cell Cycle
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Amplification of signal from the kinetochores
COPI-dependent Golgi-to-ER retrograde traffic
Cell Cycle
Gene Ontology Terms (38)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (439)
1 – 10 of 439
SYCE3
Tdark
Novelty: 0.22361224
p_int: 0.999999999
p_ni: 1e-9
Score: 0.188
Data Source: BioPlex,STRINGDB
BFSP2
Tbio
Novelty: 0.00206411
p_int: 0.999998843
p_ni: 0.000001157
Score: 0.332
Data Source: BioPlex,STRINGDB
MED4
Tbio
Family: Enzyme
Novelty: 0.01200585
p_int: 0.999978674
p_ni: 0.000021326
Data Source: BioPlex
LMO1
Tbio
Novelty: 0.01670419
p_int: 0.999859343
p_ni: 0.000140611
p_wrong: 4.6e-8
Data Source: BioPlex
RABEP1
Tbio
Family: Enzyme
Novelty: 0.02318446
p_int: 0.998769463
p_ni: 0.001230536
p_wrong: 1e-9
Data Source: BioPlex
BUB1B
Tbio
Family: Kinase
Novelty: 0.00239073
Score: 0.999
Data Source: STRINGDB
CENPF
Tbio
Novelty: 0.00676983
Score: 0.999
Data Source: STRINGDB
NDC80
Tbio
Novelty: 0.00331814
Score: 0.999
Data Source: STRINGDB
BUB1
Tchem
Family: Kinase
Novelty: 0.00327514
Score: 0.999
Data Source: STRINGDB
CDC20
Tbio
Novelty: 0.00197887
Score: 0.999
Data Source: STRINGDB
Publication Statistics
PubMed Score  221.25

PubMed score by year
PubTator Score  137.6

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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