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Tchem
PRKCE
Protein kinase C epsilon type

Protein Classes
Protein Summary
Description
Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin-dependent signaling, by mediating angiotensin-2-induced activation of integrin beta-1 (ITGB1) in cardiac fibroblasts. Phosphorylates MARCKS, which phosphorylates and activates PTK2/FAK, leading to the spread of cardiomyocytes. Involved in the control of the directional transport of ITGB1 in mesenchymal cells by phosphorylating vimentin (VIM), an intermediate filament (IF) protein. In epithelial cells, associates with and phosphorylates keratin-8 (KRT8), which induces targeting of desmoplakin at desmosomes and regulates ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000306156
  • ENSP00000306124
  • ENSG00000171132

Symbol
  • PKCE
  • PKCE
  • nPKC-epsilon
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
hub protein
1
molecular function
1
protein domain
1
biological term
0.97


Related Tools
ProKinO
Thumbnail image for ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 77.98   (req: < 5)
Gene RIFs: 199   (req: <= 3)
Antibodies: 587   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 77.98   (req: >= 5)
Gene RIFs: 199   (req: > 3)
Antibodies: 587   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 49
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 126
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2
Active Ligands (126)
1 – 10 of 126
staurosporine
Rendered image for staurosporine
CHEMBL4576489
Rendered image for CHEMBL4576489
GSK690693
Rendered image for GSK690693
balanol
Rendered image for balanol
7-hydroxystaurosporine
Rendered image for 7-hydroxystaurosporine
PP-242
Rendered image for PP-242
A-674563
Rendered image for A-674563
sotrastaurin
Rendered image for sotrastaurin
Bisindolylmaleimide I
Rendered image for Bisindolylmaleimide I
GWAS Traits (31)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hematocrit
9
13
20
99.9
hemoglobin measurement
8
11
17
99.8
erythrocyte count
4
6
7
98.4
birth weight
4
2
4
92.6
heel bone mineral density
2
2
2
88.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hematocrit
20
99.9
hemoglobin measurement
17
99.8
erythrocyte count
7
98.4
birth weight
4
92.6
heel bone mineral density
2
88.3
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
protein kinase C epsilon
VGNC:7700
459203
Macaque
protein kinase C epsilon
714533
Mouse
MGI:97599
18754
Rat
RGD:61925
29340
Dog
protein kinase C epsilon
VGNC:44980
609934
Species
Name
OMA
EggNOG
Inparanoid
Chimp
protein kinase C epsilon
Macaque
protein kinase C epsilon
Mouse
Rat
Dog
protein kinase C epsilon
Protein Structure (2 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q02156-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (80)
DAG and IP3 signaling (R-HSA-1489509)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 17
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
DAG and IP3 signaling
Reactome
Effects of PIP2 hydrolysis
Reactome
Fcgamma receptor (FCGR) dependent phagocytosis
Reactome
G alpha (q) signalling events
Reactome
G alpha (z) signalling events
Name
Explore in Pharos
Explore in Source
DAG and IP3 signaling
Effects of PIP2 hydrolysis
Fcgamma receptor (FCGR) dependent phagocytosis
G alpha (q) signalling events
G alpha (z) signalling events
Gene Ontology Terms (59)
Items per page:
10
1 – 10 of 11
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Mutant Phenotype (IMP)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (207)
1 – 10 of 207
PRKCH
Tchem
Family:  Kinase
Novelty:  0.01311926
p_int:  0.999999971
p_wrong:  2.9e-8
Score:  0.901
Data Source:  BioPlex,STRINGDB
CST2
Tbio
Novelty:  0.02114441
p_int:  0.999948938
p_ni:  0.000051056
p_wrong:  5e-9
Data Source:  BioPlex
HSP90AB3P
Tdark
p_int:  0.999897576
p_ni:  0.000102424
Data Source:  BioPlex
CST4
Tbio
Novelty:  0.00773554
p_int:  0.99947447
p_ni:  0.000525528
p_wrong:  2e-9
Data Source:  BioPlex
TIMM10B
Tdark
Family:  Enzyme
Novelty:  0.36798313
p_int:  0.999207637
p_ni:  0.000786403
p_wrong:  0.00000596
Data Source:  BioPlex
OGFR
Tbio
Novelty:  0.01046109
p_int:  0.991075429
p_ni:  0.008924571
Data Source:  BioPlex
CDC37
Tbio
Novelty:  0.03730196
p_int:  0.933800939
p_ni:  0.066199061
Score:  0.15
Data Source:  BioPlex,STRINGDB
ZG16B
Tbio
Novelty:  0.08792924
p_int:  0.849645586
p_ni:  0.150353816
p_wrong:  5.98e-7
Data Source:  BioPlex
PCBP3
Tbio
Novelty:  0.11681812
p_int:  0.843565462
p_ni:  0.156395032
p_wrong:  0.000039506
Data Source:  BioPlex
PRKCA
Tchem
Family:  Kinase
Novelty:  0.00057611
Score:  0.987
Data Source:  STRINGDB
Publication Statistics
PubMed Score  77.98

PubMed score by year
PubTator Score  496.35

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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