You are using an outdated browser. Please upgrade your browser to improve your experience.

Tclin
GUCY1B1
Guanylate cyclase soluble subunit beta-1

Protein Summary
Description
Mediates responses to nitric oxide (NO) by catalyzing the biosynthesis of the signaling molecule cGMP. This gene encodes the beta subunit of the soluble guanylate cyclase (sGC), which catalyzes the conversion of GTP (guanosine triphosphate) to cGMP (cyclic guanosine monophosphate). The encoded protein contains an HNOX domain, which serves as a receptor for ligands such as nitric oxide, oxygen and nitrovasodilator drugs. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000264424
  • ENSP00000264424
  • ENSG00000061918
  • ENST00000503520
  • ENSP00000420842
  • ENST00000505764
  • ENSP00000426319

Symbol
  • GUC1B3
  • GUCSB3
  • GUCY1B3
  • GUCB3
  • GC-SB3
  • GUC1B3
  • GUCSB3
  • GUCY1B3
  • GC-S-beta-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 26.27   (req: < 5)
Gene RIFs: 15   (req: <= 3)
Antibodies: 264   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 26.27   (req: >= 5)
Gene RIFs: 15   (req: > 3)
Antibodies: 264   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 6
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
1
48.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
48.1
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
guanylate cyclase 1 soluble subunit beta 1
VGNC:49037
461565
Macaque
guanylate cyclase 1 soluble subunit beta 1
100424944
Mouse
MGI:1860604
54195
Rat
RGD:2769
25202
Dog
guanylate cyclase 1 soluble subunit beta 1
VGNC:41568
553102
Species
Name
OMA
EggNOG
Inparanoid
Chimp
guanylate cyclase 1 soluble subunit beta 1
Macaque
guanylate cyclase 1 soluble subunit beta 1
Mouse
Rat
Dog
guanylate cyclase 1 soluble subunit beta 1
Protein Structure (4 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q02153-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 4 of 4
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (33)
Items per page:
1 – 5 of 11
Data Source
Name
Explore in Pharos
Explore in Source
KEGG
Platelet activation
KEGG
Oxytocin signaling pathway
KEGG
Long-term depression
KEGG
Gap junction
KEGG
Circadian entrainment
Name
Explore in Pharos
Explore in Source
Platelet activation
Oxytocin signaling pathway
Long-term depression
Gap junction
Circadian entrainment
Gene Ontology Terms (14)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (139)
1 – 10 of 139
GUCY1A1
Tclin
Family: Enzyme
Novelty: 0.02289791
p_int: 1
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
GUCY1A2
Tclin
Family: Enzyme
Novelty: 0.05335767
p_int: 1
Score: 0.986
Data Source: BioPlex,Reactome,STRINGDB
MXRA7
Tdark
Novelty: 0.20850504
p_int: 1
Score: 0.282
Data Source: BioPlex,STRINGDB
ANKMY2
Tdark
Novelty: 0.50777631
p_int: 0.999999964
p_ni: 3.6e-8
Score: 0.665
Data Source: BioPlex,STRINGDB
UACA
Tbio
Novelty: 0.05853699
p_int: 0.999514058
p_ni: 0.000485942
Score: 0.226
Data Source: BioPlex,STRINGDB
NOX5
Tchem
Family: Enzyme
Novelty: 0.00743692
p_int: 0.999502657
p_ni: 0.000497262
p_wrong: 8.2e-8
Score: 0.38
Data Source: BioPlex,STRINGDB
MTFR2
Tbio
Novelty: 0.20272025
p_int: 0.999333209
p_ni: 0.000064938
p_wrong: 0.000601853
Score: 0.188
Data Source: BioPlex,STRINGDB
USP28
Tbio
Family: Enzyme
Novelty: 0.02432294
p_int: 0.999066041
p_ni: 0.000713466
p_wrong: 0.000220493
Data Source: BioPlex
MYCBP2
Tbio
Family: Enzyme
Novelty: 0.00413684
p_int: 0.988151988
p_ni: 0.011848011
p_wrong: 1e-9
Score: 0.183
Data Source: BioPlex,STRINGDB
BBS2
Tbio
Novelty: 0.00835161
p_int: 0.821975
p_ni: 0.178025
Score: 0.212
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  26.27

PubMed score by year
PubTator Score  3.46

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by: