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Tclin
DHODH
Dihydroorotate dehydrogenase (quinone), mitochondrial

Protein Summary
Description
Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor. The protein encoded by this gene catalyzes the fourth enzymatic step, the ubiquinone-mediated oxidation of dihydroorotate to orotate, in de novo pyrimidine biosynthesis. This protein is a mitochondrial protein located on the outer surface of the inner mitochondrial membrane. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000219240
  • ENSP00000219240
  • ENSG00000102967

Symbol
  • URA1
  • POADS
  • DHOdehase
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
drug
0.91
disease perturbation
0.87
histone modification site profile
0.85
biological process
0.84
cellular component
0.81


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 458.62   (req: < 5)
Gene RIFs: 17   (req: <= 3)
Antibodies: 315   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 458.62   (req: >= 5)
Gene RIFs: 17   (req: > 3)
Antibodies: 315   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 475
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
total cholesterol measurement
2
1
3
89.2
low density lipoprotein cholesterol measurement
2
1
3
89.1
alcohol consumption measurement
1
1
1
60.8
alcohol use disorder measurement
1
1
1
60.8
fibrinogen measurement
1
1
1
13.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
total cholesterol measurement
3
89.2
low density lipoprotein cholesterol measurement
3
89.1
alcohol consumption measurement
1
60.8
alcohol use disorder measurement
1
60.8
fibrinogen measurement
1
13.5
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
dihydroorotate dehydrogenase (quinone)
VGNC:13696
454232
Macaque
dihydroorotate dehydrogenase (quinone)
706936
Mouse
MGI:1928378
56749
Rat
RGD:68352
65156
Dog
dihydroorotate dehydrogenase (quinone)
VGNC:53333
610755
Species
Name
OMA
EggNOG
Inparanoid
Chimp
dihydroorotate dehydrogenase (quinone)
Macaque
dihydroorotate dehydrogenase (quinone)
Mouse
Rat
Dog
dihydroorotate dehydrogenase (quinone)
Protein Structure (62 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q02127-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 62
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (12)
Metabolism (R-HSA-1430728)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Metabolism of nucleotides
Reactome
Nucleobase biosynthesis
Reactome
Pyrimidine biosynthesis
Name
Explore in Pharos
Explore in Source
Metabolism
Metabolism of nucleotides
Nucleobase biosynthesis
Pyrimidine biosynthesis
Gene Ontology Terms (22)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (176)
1 – 10 of 176
TMEM95
Tdark
Novelty: 0.32261678
p_int: 0.999999994
p_ni: 6e-9
Data Source: BioPlex
SDHD
Tbio
Family: Enzyme
Novelty: 0.00167904
p_int: 0.999999871
p_ni: 4.2e-8
p_wrong: 8.7e-8
Data Source: BioPlex
BST1
Tbio
Family: Enzyme
Novelty: 0.01329061
p_int: 0.999755078
p_ni: 0.000238813
p_wrong: 0.000006109
Data Source: BioPlex
VAC14
Tbio
Novelty: 0.02677738
p_int: 0.780670251
p_ni: 0.000018153
p_wrong: 0.219311596
Score: 0.29
Data Source: BioPlex,STRINGDB
UMPS
Tclin
Family: Enzyme
Novelty: 0.00848756
Score: 0.99
Data Source: STRINGDB
CAD
Tchem
Novelty: 0.00651422
Score: 0.975
Data Source: STRINGDB
DHFR
Tclin
Family: Enzyme
Novelty: 0.00074557
Score: 0.855
Data Source: STRINGDB
GMPS
Tbio
Family: Enzyme
Novelty: 0.00611806
Score: 0.851
Data Source: STRINGDB
MRTO4
Tbio
Novelty: 0.06676322
Score: 0.849
Data Source: STRINGDB
CYC1
Tbio
Novelty: 0.01369865
Score: 0.844
Data Source: STRINGDB
Publication Statistics
PubMed Score  458.62

PubMed score by year
PubTator Score  137.59

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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