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Tclin
DHODH
Dihydroorotate dehydrogenase (quinone), mitochondrial

Protein Summary
Description
Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor. The protein encoded by this gene catalyzes the fourth enzymatic step, the ubiquinone-mediated oxidation of dihydroorotate to orotate, in de novo pyrimidine biosynthesis. This protein is a mitochondrial protein located on the outer surface of the inner mitochondrial membrane. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000219240
  • ENSP00000219240
  • ENSG00000102967

Symbol
  • URA1
  • POADS
  • DHOdehase
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
drug
0.91
disease perturbation
0.87
histone modification site profile
0.85
biological process
0.84
cellular component
0.81


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 591.6   (req: < 5)
Gene RIFs: 17   (req: <= 3)
Antibodies: 315   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 591.6   (req: >= 5)
Gene RIFs: 17   (req: > 3)
Antibodies: 315   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 616
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2