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Tclin
GUCY1A1
Guanylate cyclase soluble subunit alpha-1

Protein Summary
Description
Soluble guanylate cyclases are heterodimeric proteins that catalyze the conversion of GTP to 3',5'-cyclic GMP and pyrophosphate. The protein encoded by this gene is an alpha subunit of this complex and it interacts with a beta subunit to form the guanylate cyclase enzyme, which is activated by nitric oxide. Several transcript variants encoding a few different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000296518
  • ENSP00000296518
  • ENSG00000164116
  • ENST00000455639
  • ENSP00000412201
  • ENST00000506455
  • ENSP00000424361
  • ENST00000511108
  • ENSP00000421493
  • ENST00000511507
  • ENSP00000426968
  • ENST00000513574
  • ENSP00000426040

Symbol
  • GUC1A3
  • GUCSA3
  • GUCY1A3
  • GUCA3
  • MYMY6
  • GC-SA3
  • GUC1A3
  • GUCSA3
  • GUCY1A3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 42.11   (req: < 5)
Gene RIFs: 21   (req: <= 3)
Antibodies: 267   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 42.11   (req: >= 5)
Gene RIFs: 21   (req: > 3)
Antibodies: 267   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 5
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (117)
GUCY1B1
Tclin
Family:  Enzyme
Novelty:  0.03618378
p_int:  1
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
ANKMY2
Tdark
Novelty:  0.50777631
p_int:  0.898312754
p_ni:  0.000004325
p_wrong:  0.101682921
Score:  0.878
Data Source:  BioPlex,STRINGDB
PRKG2
Tchem
Family:  Kinase
Novelty:  0.0138455
Score:  0.912
Data Source:  STRINGDB
ITPA
Tbio
Family:  Enzyme
Novelty:  0.00235169
Score:  0.91
Data Source:  STRINGDB
PRKG1
Tchem
Family:  Kinase
Novelty:  0.0014943
Score:  0.907
Data Source:  STRINGDB
NUDT2
Tbio
Family:  Enzyme
Novelty:  0.0201004
Score:  0.9
Data Source:  STRINGDB
PDE5A
Tclin
Family:  Enzyme
Novelty:  0.00032205
Score:  0.831
Data Source:  STRINGDB
NOS1
Tchem
Family:  Enzyme
Novelty:  0.00032064
Score:  0.824
Data Source:  STRINGDB
GUCY1A2
Tclin
Family:  Enzyme
Novelty:  0.05335767
Score:  0.82
Data Source:  STRINGDB
GCH1
Tbio
Family:  Enzyme
Novelty:  0.0025793
Score:  0.81
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (36)
Find Similar Targets
Items per page:
1 – 5 of 11
Data Source
Name
Explore in Pharos
Explore in Source
KEGG
Platelet activation
KEGG
Oxytocin signaling pathway
KEGG
Long-term depression
KEGG
Gap junction
KEGG
Circadian entrainment
Name
Explore in Pharos
Explore in Source
Platelet activation
Oxytocin signaling pathway
Long-term depression
Gap junction
Circadian entrainment
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (12)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
8
7
4
1.1
94.1
Agents acting on the renin-angiotensin system use measurement
1
1
1
58.4
lymphocyte count
2
2
2
57.1
2
1
0
1.1
56.4
diastolic blood pressure
1
1
1
42.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
4
1.1
94.1
Agents acting on the renin-angiotensin system use measurement
1
58.4
lymphocyte count
2
57.1
0
1.1
56.4
diastolic blood pressure
1
42.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
guanylate cyclase 1 soluble subunit alpha 1
VGNC:49078
100608597
Macaque
guanylate cyclase 1 soluble subunit alpha 1
699365
Mouse
MGI:1926562
60596
Rat
RGD:68436
497757
Dog
guanylate cyclase 1 soluble subunit alpha 1
VGNC:41567
482663
Species
Name
OMA
EggNOG
Inparanoid
Chimp
guanylate cyclase 1 soluble subunit alpha 1
Macaque
guanylate cyclase 1 soluble subunit alpha 1
Mouse
Rat
Dog
guanylate cyclase 1 soluble subunit alpha 1
Publication Statistics
PubMed Score 42.11
PubMed score by year
PubTator Score 13.32
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title