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Tclin
GUCY1A1
Guanylate cyclase soluble subunit alpha-1

Protein Summary
Description
Soluble guanylate cyclases are heterodimeric proteins that catalyze the conversion of GTP to 3',5'-cyclic GMP and pyrophosphate. The protein encoded by this gene is an alpha subunit of this complex and it interacts with a beta subunit to form the guanylate cyclase enzyme, which is activated by nitric oxide. Several transcript variants encoding a few different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000296518
  • ENSP00000296518
  • ENSG00000164116
  • ENST00000455639
  • ENSP00000412201
  • ENST00000506455
  • ENSP00000424361
  • ENST00000511108
  • ENSP00000421493
  • ENST00000511507
  • ENSP00000426968
  • ENST00000513574
  • ENSP00000426040

Symbol
  • GUC1A3
  • GUCSA3
  • GUCY1A3
  • GUCA3
  • MYMY6
  • GC-SA3
  • GUC1A3
  • GUCSA3
  • GUCY1A3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 42.11   (req: < 5)
Gene RIFs: 21   (req: <= 3)
Antibodies: 267   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 42.11   (req: >= 5)
Gene RIFs: 21   (req: > 3)
Antibodies: 267   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 5
GWAS Traits (12)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
8
7
4
1.1
94.1
Agents acting on the renin-angiotensin system use measurement
1
1
1
58.4
lymphocyte count
2
2
2
57.1
2
1
0
1.1
56.4
Calcium channel blocker use measurement
1
1
1
42.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
4
1.1
94.1
Agents acting on the renin-angiotensin system use measurement
1
58.4
lymphocyte count
2
57.1
0
1.1
56.4
Calcium channel blocker use measurement
1
42.3
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
guanylate cyclase 1 soluble subunit alpha 1
VGNC:49078
100608597
Macaque
guanylate cyclase 1 soluble subunit alpha 1
699365
Mouse
MGI:1926562
60596
Rat
RGD:68436
497757
Dog
guanylate cyclase 1 soluble subunit alpha 1
VGNC:41567
482663
Species
Name
OMA
EggNOG
Inparanoid
Chimp
guanylate cyclase 1 soluble subunit alpha 1
Macaque
guanylate cyclase 1 soluble subunit alpha 1
Mouse
Rat
Dog
guanylate cyclase 1 soluble subunit alpha 1
Protein Structure (2 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q02108-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (36)
Items per page:
1 – 5 of 11
Data Source
Name
Explore in Pharos
Explore in Source
KEGG
Platelet activation
KEGG
Oxytocin signaling pathway
KEGG
Long-term depression
KEGG
Gap junction
KEGG
Circadian entrainment
Name
Explore in Pharos
Explore in Source
Platelet activation
Oxytocin signaling pathway
Long-term depression
Gap junction
Circadian entrainment
Gene Ontology Terms (15)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (117)
1 – 10 of 117
GUCY1B1
Tclin
Family:  Enzyme
Novelty:  0.03618378
p_int:  1
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
ANKMY2
Tdark
Novelty:  0.50777631
p_int:  0.898312754
p_ni:  0.000004325
p_wrong:  0.101682921
Score:  0.878
Data Source:  BioPlex,STRINGDB
PRKG2
Tchem
Family:  Kinase
Novelty:  0.0138455
Score:  0.912
Data Source:  STRINGDB
ITPA
Tbio
Family:  Enzyme
Novelty:  0.00235169
Score:  0.91
Data Source:  STRINGDB
PRKG1
Tchem
Family:  Kinase
Novelty:  0.0014943
Score:  0.907
Data Source:  STRINGDB
NUDT2
Tbio
Family:  Enzyme
Novelty:  0.0201004
Score:  0.9
Data Source:  STRINGDB
PDE5A
Tclin
Family:  Enzyme
Novelty:  0.00032205
Score:  0.831
Data Source:  STRINGDB
NOS1
Tchem
Family:  Enzyme
Novelty:  0.00032064
Score:  0.824
Data Source:  STRINGDB
GUCY1A2
Tclin
Family:  Enzyme
Novelty:  0.05335767
Score:  0.82
Data Source:  STRINGDB
GCH1
Tbio
Family:  Enzyme
Novelty:  0.0025793
Score:  0.81
Data Source:  STRINGDB
Publication Statistics
PubMed Score  42.11

PubMed score by year
PubTator Score  13.32

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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