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Tbio
RHAG
Ammonium transporter Rh type A

Protein Summary
Description
Associated with rhesus blood group antigen expression (PubMed:19744193). May be part of an oligomeric complex which is likely to have a transport or channel function in the erythrocyte membrane (PubMed:11062476, PubMed:11861637). Involved in ammonia transport across the erythrocyte membrane (PubMed:21849667, PubMed:22012326). Seems to act in monovalent cation transport (PubMed:18931342, PubMed:21849667). The protein encoded by this gene is erythrocyte-specific and is thought to be part of a membrane channel that transports ammonium and carbon dioxide across the blood cell membrane. The encoded protein appears to interact with Rh blood group antigens and Rh30 polypeptides. Defects in this gene are a cause of regulator type Rh-null hemolytic anemia (RHN), or Rh-deficiency syndrome.[provided by RefSeq, Mar 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000371175
  • ENSP00000360217
  • ENSG00000112077
  • ENST00000646939
  • ENSP00000494709

Symbol
  • RH50
  • OHS
  • RH2
  • OHST
  • RHNR
  • Rh50
  • CD241
  • RH50A
  • Rh50GP
  • SLC42A1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.6
kinase perturbation
0.6
molecular function
0.6
co-expressed gene
0.57
virus perturbation
0.5


Related Tools
RESOLUTE
RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1120.08   (req: < 5)
Gene RIFs: 25   (req: <= 3)
Antibodies: 60   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1120.08   (req: >= 5)
Gene RIFs: 25   (req: > 3)
Antibodies: 60   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular volume
1
1
1
6.7
reticulocyte measurement
1
1
1
3.3
reticulocyte count
1
1
1
3.2
mean reticulocyte volume
1
1
1
2.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular volume
1
6.7
reticulocyte measurement
1
3.3
reticulocyte count
1
3.2
mean reticulocyte volume
1
2.7
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
Rh associated glycoprotein
VGNC:48932
450105
Macaque
Rh associated glycoprotein
574120
Mouse
MGI:1202713
19743
Rat
RGD:61871
65207
Dog
Rh associated glycoprotein
VGNC:45542
481833
Species
Name
OMA
EggNOG
Inparanoid
Chimp
Rh associated glycoprotein
Macaque
Rh associated glycoprotein
Mouse
Rat
Dog
Rh associated glycoprotein
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q02094-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (11)
Defective RHAG causes regulator type Rh-null hemolytic anemia (RHN) (R-HSA-5619042)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 11
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Defective RHAG causes regulator type Rh-null hemolytic anemia (RHN)
Reactome
Disease
Reactome
Disorders of transmembrane transporters
Reactome
Erythrocytes take up carbon dioxide and release oxygen
Reactome
Erythrocytes take up oxygen and release carbon dioxide
Name
Explore in Pharos
Explore in Source
Defective RHAG causes regulator type Rh-null hemolytic anemia (RHN)
Disease
Disorders of transmembrane transporters
Erythrocytes take up carbon dioxide and release oxygen
Erythrocytes take up oxygen and release carbon dioxide
Protein-Protein Interactions (66)
1 – 10 of 66
GYPB
Tbio
Novelty: 0.00442195
Score: 0.922
Data Source: STRINGDB
CD47
Tchem
Novelty: 0.00129086
Score: 0.84
Data Source: STRINGDB
RBL2
Tbio
Novelty: 0.00121893
Score: 0.795
Data Source: STRINGDB
STMN4
Tbio
Novelty: 0.00422625
Score: 0.791
Data Source: STRINGDB
TYR
Tclin
Family: Enzyme
Novelty: 0.00048513
Score: 0.771
Data Source: STRINGDB
EFHD1
Tbio
Novelty: 0.00808906
Score: 0.766
Data Source: STRINGDB
SPTA1
Tbio
Novelty: 0.00456741
Score: 0.743
Data Source: STRINGDB
SLC4A1
Tbio
Family: Transporter
Novelty: 0.00290106
Score: 0.724
Data Source: STRINGDB
GYPA
Tbio
Novelty: 0.00067203
Score: 0.716
Data Source: STRINGDB
HBE1
Tbio
Novelty: 0.00125958
Score: 0.703
Data Source: STRINGDB
Publication Statistics
PubMed Score  1120.08

PubMed score by year
PubTator Score  375.48

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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