Tbio RHAG Ammonium transporter Rh type A

Protein Summary

Description

Associated with rhesus blood group antigen expression (PubMed:19744193). May be part of an oligomeric complex which is likely to have a transport or channel function in the erythrocyte membrane (PubMed:11062476, PubMed:11861637). Involved in ammonia transport across the erythrocyte membrane (PubMed:21849667, PubMed:22012326). Seems to act in monovalent cation transport (PubMed:18931342, PubMed:21849667). The protein encoded by this gene is erythrocyte-specific and is thought to be part of a membrane channel that transports ammonium and carbon dioxide across the blood cell membrane. The encoded protein appears to interact with Rh blood group antigens and Rh30 polypeptides. Defects in this gene are a cause of regulator type Rh-null hemolytic anemia (RHN), or Rh-deficiency syndrome.[provided by RefSeq, Mar 2009]

Uniprot Accession IDs

• Q02094
• B2R8T8
• O43514
• O43515
• Q7L8L3
• Q9H454

Gene Name

• RHAG

Ensembl ID

• ENST00000371175
• ENSP00000360217
• ENSG00000112077
• ENST00000646939
• ENSP00000494709

Symbol

• RH50
• OHS
• RH2
• OHST
• RHNR
• Rh50
• CD241
• RH50A
• Rh50GP
• SLC42A1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
gene perturbation	0.6
kinase perturbation	0.6
molecular function	0.6
co-expressed gene	0.57
virus perturbation	0.5

Protein Classes

PANTHER Classes

Protein / Transporter / Cation Transporter / Ammonium Transporter Rh Type A

DTO Classes

Protein / Transporter / Slc Superfamily Of Solute Carriers / Slc42 Family Of Rhesus Glycoprotein Ammonium Transporters / Ammonium Transporter Rh Type A

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1374.01   (req: < 5)

Gene RIFs: 30   (req: <= 3)

Antibodies: 60   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1374.01   (req: >= 5)

Gene RIFs: 30   (req: > 3)

Antibodies: 60   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0