You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
MEF2B
Myocyte-specific enhancer factor 2B

Protein Summary
Description
Transcriptional activator which binds specifically to the MEF2 element, 5'-YTA[AT](4)TAR-3', found in numerous muscle-specific genes. Activates transcription via this element. May be involved in muscle-specific and/or growth factor-related transcription. The product of this gene is a member of the MADS/MEF2 family of DNA binding proteins. The protein is thought to regulate gene expression, including expression of the smooth muscle myosin heavy chain gene. This region undergoes considerable alternative splicing, with transcripts supporting two non-overlapping loci (GeneID 729991 and 100271849) as well as numerous read-through transcripts that span both loci (annotated as GeneID 4207). Several isoforms of this protein are expressed from either this locus or from some of the read-through transcripts annotated on GeneID 4207. [provided by RefSeq, Jan 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000424583
  • ENSP00000402154
  • ENSG00000213999

Symbol
  • XMEF2
  • RSRFR2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 21.48   (req: < 5)
Gene RIFs: 16   (req: <= 3)
Antibodies: 132   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 21.48   (req: >= 5)
Gene RIFs: 16   (req: > 3)
Antibodies: 132   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
diastolic blood pressure
2
1
2
24.3
mean arterial pressure
1
1
1
19.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
diastolic blood pressure
2
24.3
mean arterial pressure
1
19.7
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
myocyte enhancer factor 2B
455870
Rat
RGD:1561733
498607
Dog
myocyte enhancer factor 2B
609739
Horse
myocyte enhancer factor 2B
100071129
Cow
myocyte enhancer factor 2B
100271851
Species
Name
OMA
EggNOG
Inparanoid
Chimp
myocyte enhancer factor 2B
Rat
Dog
myocyte enhancer factor 2B
Horse
myocyte enhancer factor 2B
Cow
myocyte enhancer factor 2B
Protein Structure (5 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q02080-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 5
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (67)
Developmental Biology (R-HSA-1266738)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Developmental Biology
Reactome
Myogenesis
Name
Explore in Pharos
Explore in Source
Developmental Biology
Myogenesis
Gene Ontology Terms (12)
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence Alignment (ISA)
NTNU_SB
Non-traceable Author Statement (NAS)
ProtInc
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (44)
1 – 10 of 44
MEF2A
Tbio
Family: TF
Novelty: 0.00439393
p_int: 0.999999999
p_ni: 1e-9
Score: 0.165
Data Source: BioPlex,STRINGDB
MEF2D
Tbio
Family: TF
Novelty: 0.00732653
p_int: 0.999999974
p_ni: 9e-9
p_wrong: 1.7e-8
Score: 0.172
Data Source: BioPlex,STRINGDB
MEF2C
Tbio
Family: TF
Novelty: 0.00232724
p_int: 0.999997108
p_wrong: 0.000002891
Data Source: BioPlex
CABIN1
Tbio
Novelty: 0.02528794
p_int: 0.991406975
p_ni: 0.008593017
p_wrong: 9e-9
Score: 0.944
Data Source: BioPlex,STRINGDB
UBN2
Tbio
Novelty: 0.09777456
p_int: 0.947954582
p_ni: 0.020858544
p_wrong: 0.031186874
Data Source: BioPlex
CREBBP
Tchem
Family: Epigenetic
Novelty: 0.00111166
Score: 0.798
Data Source: STRINGDB
RFXANK
Tbio
Novelty: 0.00355465
Score: 0.781
Data Source: STRINGDB
EP300
Tchem
Family: Epigenetic
Novelty: 0.00055009
Score: 0.758
Data Source: STRINGDB
BCL6
Tchem
Family: TF
Novelty: 0.00066258
Score: 0.749
Data Source: STRINGDB
NCAN
Tbio
Novelty: 0.00401824
Score: 0.746
Data Source: STRINGDB
Publication Statistics
PubMed Score  21.48

PubMed score by year
PubTator Score  20.86

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer