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Tbio
MEF2A
Myocyte-specific enhancer factor 2A

Protein Summary
Description
Transcriptional activator which binds specifically to the MEF2 element, 5'-YTA[AT](4)TAR-3', found in numerous muscle-specific genes. Also involved in the activation of numerous growth factor- and stress-induced genes. Mediates cellular functions not only in skeletal and cardiac muscle development, but also in neuronal differentiation and survival. Plays diverse roles in the control of cell growth, survival and apoptosis via p38 MAPK signaling in muscle-specific and/or growth factor-related transcription. In cerebellar granule neurons, phosphorylated and sumoylated MEF2A represses transcription of NUR77 promoting synaptic differentiation. Associates with chromatin to the ZNF16 promoter. The protein encoded by this gene is a DNA-binding transcription factor that activates many muscle-specific, growth factor-induced, and stress-induced genes. The encoded protein can act as a homodimer or as a heterodimer and is involved in several cellular processes, including muscle development, neurona ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000338042
  • ENSP00000337202
  • ENSG00000068305
  • ENST00000354410
  • ENSP00000346389
  • ENST00000449277
  • ENSP00000399460
  • ENST00000557785
  • ENSP00000453441
  • ENST00000557942
  • ENSP00000453095
  • ENST00000558812
  • ENSP00000454120

Symbol
  • MEF2
  • mef2
  • ADCAD1
  • RSRFC4
  • RSRFC9
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
1
transcription factor perturbation
1
biological process
0.99
hub protein
0.95
transcription factor
0.9


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 250.7   (req: < 5)
Gene RIFs: 71   (req: <= 3)
Antibodies: 970   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 250.7   (req: >= 5)
Gene RIFs: 71   (req: > 3)
Antibodies: 970   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 33
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
vitamin D measurement
2
2
2
80.1
systolic blood pressure
1
1
1
48.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
vitamin D measurement
2
80.1
systolic blood pressure
1
48.6
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
myocyte enhancer factor 2A
VGNC:1917
453680
Macaque
myocyte enhancer factor 2A
708956
Mouse
MGI:99532
17258
Rat
RGD:1359360
309957
Dog
myocyte enhancer factor 2A
VGNC:43143
479021
Species
Name
OMA
EggNOG
Inparanoid
Chimp
myocyte enhancer factor 2A
Macaque
myocyte enhancer factor 2A
Mouse
Rat
Dog
myocyte enhancer factor 2A
Protein Data Bank (8)
1 – 5 of 8
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (47)
Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 31
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
Developmental Biology
Reactome
ERK/MAPK targets
Reactome
Immune System
Reactome
Innate Immune System
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
Developmental Biology
ERK/MAPK targets
Immune System
Innate Immune System
Gene Ontology Terms (38)
Items per page:
10
1 – 10 of 16
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Protein-Protein Interactions (165)
1 – 10 of 165
MEF2B
Tbio
Family: TF
Novelty: 0.03094093
p_int: 0.999999999
p_ni: 1e-9
Score: 0.165
Data Source: BioPlex,STRINGDB
TSR3
Tdark
Novelty: 0.09337944
p_int: 0.994249057
p_ni: 0.005750942
p_wrong: 1e-9
Score: 0.209
Data Source: BioPlex,STRINGDB
EP300
Tchem
Family: Epigenetic
Novelty: 0.00055009
Score: 0.999
Data Source: STRINGDB
MYOG
Tbio
Family: TF
Novelty: 0.00074867
Score: 0.988
Data Source: Reactome,STRINGDB
MYOD1
Tbio
Family: TF
Novelty: 0.00053412
Score: 0.987
Data Source: Reactome,STRINGDB
CREBBP
Tchem
Family: Epigenetic
Novelty: 0.00111166
Score: 0.983
Data Source: STRINGDB
HDAC5
Tclin
Family: Epigenetic
Novelty: 0.00484422
Score: 0.978
Data Source: STRINGDB
MAPK7
Tchem
Family: Kinase
Novelty: 0.00257226
Score: 0.978
Data Source: Reactome,STRINGDB
CABIN1
Tbio
Novelty: 0.02528794
Score: 0.976
Data Source: STRINGDB
HDAC9
Tclin
Family: Epigenetic
Novelty: 0.00382278
Score: 0.973
Data Source: STRINGDB
Publication Statistics
PubMed Score  250.70

PubMed score by year
PubTator Score  326.84

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer