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Tbio
MYL5
Myosin light chain 5

Protein Summary
Description
This gene encodes one of the myosin light chains, a component of the hexameric ATPase cellular motor protein myosin. Myosin is composed of two heavy chains, two nonphosphorylatable alkali light chains, and two phosphorylatable regulatory light chains. This gene product, one of the regulatory light chains, is expressed in fetal muscle and in adult retina, cerebellum, and basal ganglia. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000400159
  • ENSP00000383023
  • ENSG00000215375
  • ENST00000505477
  • ENSP00000423118
  • ENST00000506838
  • ENSP00000427153
  • ENST00000511290
  • ENSP00000425162

Symbol
  • MYLC2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
pathway
0.72
cellular component
0.57
tissue sample
0.52
small molecule perturbation
0.51
cell type or tissue
0.5


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 68.14   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 69   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 68.14   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 69   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Protein-Protein Interactions (98)
1 – 10 of 98
MYL2
Tbio
Novelty:  0.0018887
p_int:  0.999999672
p_wrong:  3.28e-7
Score:  0.493
Data Source:  BioPlex,STRINGDB
MYLK
Tchem
Family:  Kinase
Novelty:  0.00102277
Score:  0.992
Data Source:  STRINGDB
MYH11
Tbio
Novelty:  0.00142474
Score:  0.975
Data Source:  STRINGDB
TPM4
Tbio
Novelty:  0.00557194
Score:  0.956
Data Source:  STRINGDB
MYH13
Tbio
Novelty:  0.01077846
Score:  0.955
Data Source:  STRINGDB
TPM1
Tbio
Novelty:  0.00261206
Score:  0.954
Data Source:  STRINGDB
TPM2
Tbio
Novelty:  0.00406572
Score:  0.954
Data Source:  STRINGDB
TPM3
Tbio
Novelty:  0.00108151
Score:  0.953
Data Source:  STRINGDB
MYH14
Tchem
Novelty:  0.00874871
Score:  0.95
Data Source:  STRINGDB
MYH8
Tbio
Novelty:  0.01020559
Score:  0.95
Data Source:  STRINGDB
GWAS Traits (19)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil count
3
2
3
90.3
myeloid white cell count
2
2
2
89.7
monocyte percentage of leukocytes
2
2
2
89.5
leukocyte count
2
2
2
86.2
3
2
2
1.1
83.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil count
3
90.3
myeloid white cell count
2
89.7
monocyte percentage of leukocytes
2
89.5
leukocyte count
2
86.2
2
1.1
83.4
Find similar targets by:
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
myosin light chain 5
VGNC:48920
750383
Macaque
myosin light chain 5
697765
Dog
myosin light chain 5
VGNC:43545
479135
Horse
myosin light chain 5
VGNC:20486
100051591
Pig
myosin light chain 5 [Source:HGNC Symbol;Acc:HGNC:7586]
Species
Name
OMA
EggNOG
Inparanoid
Chimp
myosin light chain 5
Macaque
myosin light chain 5
Dog
myosin light chain 5
Horse
myosin light chain 5
Pig
myosin light chain 5 [Source:HGNC Symbol;Acc:HGNC:7586]
Publication Statistics
PubMed Score 68.14
PubMed score by year
PubTator Score 3.51
PubTator score by year