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Tbio
AKAP17A
A-kinase anchor protein 17A

Protein Summary
Description
Splice factor regulating alternative splice site selection for certain mRNA precursors. Mediates regulation of pre-mRNA splicing in a PKA-dependent manner. This locus encodes a protein kinase A anchoring protein. The encoded protein is part of the spliceosome complex and is involved in the regulation of alternate splicing in some mRNA precursors. Alternatively spliced transcript variants have been identified for this gene.[provided by RefSeq, Sep 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000313871
  • ENSP00000324827
  • ENSG00000197976
  • ENST00000474361
  • ENSP00000435479

Symbol
  • CXYorf3
  • DXYS155E
  • SFRS17A
  • XE7
  • XE7
  • 721P
  • XE7Y
  • CCDC133
  • CXYorf3
  • PRKA17A
  • SFRS17A
  • AKAP-17A
  • DXYS155E
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.72
tissue sample
0.7
cellular component
0.67
kinase perturbation
0.6
tissue
0.59


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 69.02   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 206   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 69.02   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 206   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Gene Ontology Terms (12)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Protein-Protein Interactions (67)
1 – 10 of 67
JMJD6
Tbio
Family: Enzyme
Novelty: 0.00134844
p_int: 1
Data Source: BioPlex
ACTN3
Tbio
Novelty: 0.00478226
p_int: 0.999998985
p_ni: 0.000001015
Score: 0.187
Data Source: BioPlex,STRINGDB
CKM
Tbio
Family: Kinase
Novelty: 0.00329483
p_int: 0.999978786
p_ni: 0.000021192
p_wrong: 2.2e-8
Score: 0.173
Data Source: BioPlex,STRINGDB
PNN
Tbio
Novelty: 0.00945912
p_int: 0.999897846
p_ni: 0.000102154
Score: 0.356
Data Source: BioPlex,STRINGDB
MYH7
Tbio
Novelty: 0.00255398
p_int: 0.999635665
p_ni: 0.000291924
p_wrong: 0.000072412
Score: 0.167
Data Source: BioPlex,STRINGDB
MYH4
Tbio
Novelty: 0.00797522
p_int: 0.999516462
p_ni: 0.000318693
p_wrong: 0.000164845
Score: 0.173
Data Source: BioPlex,STRINGDB
ANKRD17
Tbio
Novelty: 0.05032241
p_int: 0.99630114
p_ni: 0.00369886
Score: 0.155
Data Source: BioPlex,STRINGDB
UBE2O
Tbio
Novelty: 0.07223942
p_int: 0.991940238
p_ni: 0.008059761
p_wrong: 1e-9
Data Source: BioPlex
ANKHD1
Tbio
Novelty: 0.08323329
p_int: 0.978481822
p_ni: 0.021518178
Score: 0.166
Data Source: BioPlex,STRINGDB
CAAP1
Tbio
Family: Enzyme
Novelty: 0.02206429
p_int: 0.967505368
p_ni: 0.032494632
Score: 0.825
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  69.02

PubMed score by year
PubTator Score  8

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer