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Tbio
TAGLN
Transgelin

Protein Summary
Description
Actin cross-linking/gelling protein (By similarity). Involved in calcium interactions and contractile properties of the cell that may contribute to replicative senescence. This gene encodes a shape change and transformation sensitive actin-binding protein which belongs to the calponin family. It is ubiquitously expressed in vascular and visceral smooth muscle, and is an early marker of smooth muscle differentiation. The encoded protein is thought to be involved in calcium-independent smooth muscle contraction. It acts as a tumor suppressor, and the loss of its expression is an early event in cell transformation and the development of some tumors, coinciding with cellular plasticity. The encoded protein has a domain architecture consisting of an N-terminal calponin homology (CH) domain and a C-terminal calponin-like (CLIK) domain. Mice with a knockout of the orthologous gene are viable and fertile but their vascular smooth muscle cells exhibit alterations in the distribution of the acti ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000278968
  • ENSP00000278968
  • ENSG00000149591
  • ENST00000392951
  • ENSP00000376678
  • ENST00000525531
  • ENSP00000432054
  • ENST00000530649
  • ENSP00000431941
  • ENST00000532870
  • ENSP00000432282

Symbol
  • SM22
  • WS3-10
  • SM22
  • SMCC
  • TAGLN1
  • WS3-10
  • SM22-alpha
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.99
PubMedID
0.97
transcription factor perturbation
0.91
small molecule perturbation
0.86
disease perturbation
0.79


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 417.09   (req: < 5)
Gene RIFs: 55   (req: <= 3)
Antibodies: 635   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 417.09   (req: >= 5)
Gene RIFs: 55   (req: > 3)
Antibodies: 635   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Gene Ontology Terms (4)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (121)
1 – 10 of 121
PSMD3
Tbio
Family: Enzyme
Novelty: 0.05068389
p_int: 0.998462548
p_ni: 1.3e-8
p_wrong: 0.001537439
Data Source: BioPlex
MYOCD
Tbio
Novelty: 0.00397684
Score: 0.951
Data Source: STRINGDB
FABP5
Tchem
Novelty: 0.00700934
Score: 0.889
Data Source: STRINGDB
FKBP2
Tbio
Family: Enzyme
Novelty: 0.01101194
Score: 0.88
Data Source: STRINGDB
MYL9
Tbio
Novelty: 0.00271264
Score: 0.879
Data Source: STRINGDB
FKBP1A
Tclin
Family: Enzyme
Novelty: 0.00153087
Score: 0.874
Data Source: STRINGDB
FKBP1B
Tchem
Family: Enzyme
Novelty: 0.00640101
Score: 0.873
Data Source: STRINGDB
ENO2
Tbio
Family: Enzyme
Novelty: 0.00021254
Score: 0.865
Data Source: STRINGDB
ACTA2
Tbio
Novelty: 0.00281551
Score: 0.854
Data Source: STRINGDB
MYH11
Tbio
Novelty: 0.00189652
Score: 0.841
Data Source: STRINGDB
Publication Statistics
PubMed Score  417.09

PubMed score by year
PubTator Score  221.08

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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