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Tbio
TAGLN
Transgelin

Protein Summary
Description
Actin cross-linking/gelling protein (By similarity). Involved in calcium interactions and contractile properties of the cell that may contribute to replicative senescence. This gene encodes a shape change and transformation sensitive actin-binding protein which belongs to the calponin family. It is ubiquitously expressed in vascular and visceral smooth muscle, and is an early marker of smooth muscle differentiation. The encoded protein is thought to be involved in calcium-independent smooth muscle contraction. It acts as a tumor suppressor, and the loss of its expression is an early event in cell transformation and the development of some tumors, coinciding with cellular plasticity. The encoded protein has a domain architecture consisting of an N-terminal calponin homology (CH) domain and a C-terminal calponin-like (CLIK) domain. Mice with a knockout of the orthologous gene are viable and fertile but their vascular smooth muscle cells exhibit alterations in the distribution of the acti ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000278968
  • ENSP00000278968
  • ENSG00000149591
  • ENST00000392951
  • ENSP00000376678
  • ENST00000525531
  • ENSP00000432054
  • ENST00000530649
  • ENSP00000431941
  • ENST00000532870
  • ENSP00000432282

Symbol
  • SM22
  • WS3-10
  • SM22
  • SMCC
  • TAGLN1
  • WS3-10
  • SM22-alpha
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.99
PubMedID
0.97
transcription factor perturbation
0.91
small molecule perturbation
0.86
disease perturbation
0.79


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 397.64   (req: < 5)
Gene RIFs: 55   (req: <= 3)
Antibodies: 635   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 397.64   (req: >= 5)
Gene RIFs: 55   (req: > 3)
Antibodies: 635   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (121)
PSMD3
Tbio
Family:  Enzyme
Novelty:  0.03106272
p_int:  0.998462548
p_ni:  1.3e-8
p_wrong:  0.001537439
Data Source:  BioPlex
MYOCD
Tbio
Novelty:  0.00354211
Score:  0.951
Data Source:  STRINGDB
FABP5
Tchem
Novelty:  0.00570755
Score:  0.889
Data Source:  STRINGDB
FKBP2
Tchem
Family:  Enzyme
Novelty:  0.00796637
Score:  0.88
Data Source:  STRINGDB
MYL9
Tbio
Novelty:  0.00309239
Score:  0.879
Data Source:  STRINGDB
FKBP1A
Tclin
Family:  Enzyme
Novelty:  0.00116174
Score:  0.874
Data Source:  STRINGDB
FKBP1B
Tchem
Family:  Enzyme
Novelty:  0.00541222
Score:  0.873
Data Source:  STRINGDB
ENO2
Tbio
Family:  Enzyme
Novelty:  0.00016748
Score:  0.865
Data Source:  STRINGDB
ACTA2
Tbio
Novelty:  0.00199354
Score:  0.854
Data Source:  STRINGDB
MYH11
Tbio
Novelty:  0.00142474
Score:  0.841
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (22)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
triglyceride measurement
8
13
20
99.8
high density lipoprotein cholesterol measurement
7
10
12
17
99.1
apolipoprotein A 1 measurement
2
7
7
98.8
total cholesterol measurement
2
5
6
94.6
apolipoprotein B measurement
2
5
5
90.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
triglyceride measurement
20
99.8
high density lipoprotein cholesterol measurement
12
17
99.1
apolipoprotein A 1 measurement
7
98.8
total cholesterol measurement
6
94.6
apolipoprotein B measurement
5
90.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
transgelin
VGNC:11650
100615570
Macaque
transgelin
106993487
Mouse
MGI:106012
21345
Rat
RGD:3723
25123
Dog
transgelin
VGNC:47093
479424
Species
Name
OMA
EggNOG
Inparanoid
Chimp
transgelin
Macaque
transgelin
Mouse
Rat
Dog
transgelin
Publication Statistics
PubMed Score 397.64
PubMed score by year
PubTator Score 221.08
PubTator score by year
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Related Publications
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PMID
Year
Title