Tbio ROR2 Tyrosine-protein kinase transmembrane receptor ROR2

Protein Summary

Description

Tyrosine-protein kinase receptor which may be involved in the early formation of the chondrocytes. It seems to be required for cartilage and growth plate development (By similarity). Phosphorylates YWHAB, leading to induction of osteogenesis and bone formation (PubMed:17717073). In contrast, has also been shown to have very little tyrosine kinase activity in vitro. May act as a receptor for wnt ligand WNT5A which may result in the inhibition of WNT3A-mediated signaling (PubMed:25029443). The protein encoded by this gene is a receptor protein tyrosine kinase and type I transmembrane protein that belongs to the ROR subfamily of cell surface receptors. The protein may be involved in the early formation of the chondrocytes and may be required for cartilage and growth plate development. Mutations in this gene can cause brachydactyly type B, a skeletal disorder characterized by hypoplasia/aplasia of distal phalanges and nails. In addition, mutations in this gene can cause the autosomal recessive form of Robinow syndrome, which is characterized by skeletal dysplasia with generalized limb bone shortening, segmental defects of the spine, brachydactyly, and a dysmorphic facial appearance. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q01974
• Q59GF5
• Q5SPI5
• Q9HAY7
• Q9HB61

Gene Name

• ROR2

Ensembl ID

• ENST00000375708
• ENSP00000364860
• ENSG00000169071

Symbol

• NTRKR2
• BDB
• BDB1
• NTRKR2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	1
molecular function	0.99
biological process	0.87
phenotype	0.79
PubMedID	0.73

Protein Classes

DTO Classes

Protein / Kinase / Protein Kinase / Tk Group / Ror Family / Tyrosine-protein Kinase Transmembrane Receptor Ror2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 85.8   (req: < 5)

Gene RIFs: 105   (req: <= 3)

Antibodies: 588   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 85.8   (req: >= 5)

Gene RIFs: 105   (req: > 3)

Antibodies: 588   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 40

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0