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Tbio
ROR2
Tyrosine-protein kinase transmembrane receptor ROR2

Protein Summary
Description
Tyrosine-protein kinase receptor which may be involved in the early formation of the chondrocytes. It seems to be required for cartilage and growth plate development (By similarity). Phosphorylates YWHAB, leading to induction of osteogenesis and bone formation (PubMed:17717073). In contrast, has also been shown to have very little tyrosine kinase activity in vitro. May act as a receptor for wnt ligand WNT5A which may result in the inhibition of WNT3A-mediated signaling (PubMed:25029443). The protein encoded by this gene is a receptor protein tyrosine kinase and type I transmembrane protein that belongs to the ROR subfamily of cell surface receptors. The protein may be involved in the early formation of the chondrocytes and may be required for cartilage and growth plate development. Mutations in this gene can cause brachydactyly type B, a skeletal disorder characterized by hypoplasia/aplasia of distal phalanges and nails. In addition, mutations in this gene can cause the autosomal rec ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000375708
  • ENSP00000364860
  • ENSG00000169071

Symbol
  • NTRKR2
  • BDB
  • BDB1
  • NTRKR2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
molecular function
0.99
biological process
0.87
phenotype
0.79
PubMedID
0.73


Related Tools
ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 63.84   (req: < 5)
Gene RIFs: 79   (req: <= 3)
Antibodies: 588   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 63.84   (req: >= 5)
Gene RIFs: 79   (req: > 3)
Antibodies: 588   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 40
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
facial morphology measurement
1
1
1
33
nose morphology measurement
1
1
1
20.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
facial morphology measurement
1
33
nose morphology measurement
1
20.8
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
receptor tyrosine kinase like orphan receptor 2
VGNC:9218
464589
Macaque
receptor tyrosine kinase like orphan receptor 2
715482
Mouse
MGI:1347521
26564
Rat
RGD:1305275
306782
Dog
receptor tyrosine kinase like orphan receptor 2
VGNC:45694
484193
Species
Name
OMA
EggNOG
Inparanoid
Chimp
receptor tyrosine kinase like orphan receptor 2
Macaque
receptor tyrosine kinase like orphan receptor 2
Mouse
Rat
Dog
receptor tyrosine kinase like orphan receptor 2
Protein Structure (2 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q01974-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (40)
Beta-catenin independent WNT signaling (R-HSA-3858494)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Beta-catenin independent WNT signaling
Reactome
PCP/CE pathway
Reactome
Signal Transduction
Reactome
Signaling by WNT
Reactome
WNT5A-dependent internalization of FZD2, FZD5 and ROR2
Name
Explore in Pharos
Explore in Source
Beta-catenin independent WNT signaling
PCP/CE pathway
Signal Transduction
Signaling by WNT
WNT5A-dependent internalization of FZD2, FZD5 and ROR2
Gene Ontology Terms (50)
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
WormBase
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
ParkinsonsUK-UCL
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (73)
1 – 10 of 73
CLEC4A
Tbio
Novelty: 0.01821643
p_int: 0.999999748
p_ni: 2.51e-7
p_wrong: 1e-9
Data Source: BioPlex
ACVR2B
Tchem
Family: Kinase
Novelty: 0.00555742
p_int: 0.834577888
p_ni: 0.000137798
p_wrong: 0.165284314
Data Source: BioPlex
WNT5A
Tbio
Novelty: 0.00125563
Score: 0.99
Data Source: Reactome,STRINGDB
FZD2
Tbio
Family: GPCR
Novelty: 0.00774893
Score: 0.978
Data Source: STRINGDB
FZD5
Tbio
Family: GPCR
Novelty: 0.01673829
Score: 0.975
Data Source: STRINGDB
VANGL2
Tbio
Novelty: 0.00529796
Score: 0.967
Data Source: Reactome,STRINGDB
DVL1
Tchem
Novelty: 0.00356876
Score: 0.967
Data Source: STRINGDB
DVL3
Tbio
Novelty: 0.01606014
Score: 0.962
Data Source: STRINGDB
DVL2
Tbio
Novelty: 0.00833084
Score: 0.961
Data Source: STRINGDB
FZD4
Tchem
Family: GPCR
Novelty: 0.00577957
Score: 0.959
Data Source: STRINGDB
Publication Statistics
PubMed Score  63.84

PubMed score by year
PubTator Score  139.66

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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