Tbio ROR1 Inactive tyrosine-protein kinase transmembrane receptor ROR1

Protein Summary

Description

Has very low kinase activity in vitro and is unlikely to function as a tyrosine kinase in vivo (PubMed:25029443). Receptor for ligand WNT5A which activate downstream NFkB signaling pathway and may result in the inhibition of WNT3A-mediated signaling (PubMed:25029443, PubMed:27162350). In inner ear, crucial for spiral ganglion neurons to innervate auditory hair cells (PubMed:27162350). This gene encodes a receptor tyrosine kinase-like orphan receptor that modulates neurite growth in the central nervous system. The encoded protein is a glycosylated type I membrane protein that belongs to the ROR subfamily of cell surface receptors. It is a pseudokinase that lacks catalytic activity and may interact with the non-canonical Wnt signalling pathway. This gene is highly expressed during early embryonic development but expressed at very low levels in adult tissues. Increased expression of this gene is associated with B-cell chronic lymphocytic leukaemia. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jun 2012]

Uniprot Accession IDs

• Q01973
• Q5VVX6
• Q66K77
• Q92776

Gene Name

• ROR1

Ensembl ID

• ENST00000371079
• ENSP00000360120
• ENSG00000185483
• ENST00000371080
• ENSP00000360121

Symbol

• NTRKR1
• NTRKR1
• dJ537F10.1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	1
molecular function	0.98
trait	0.97
PubMedID	0.84
transcription factor binding site profile	0.78

Protein Classes

DTO Classes

Protein / Kinase / Protein Kinase / Tk Group / Ror Family / Tyrosine-protein Kinase Transmembrane Receptor Ror1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 55.04   (req: < 5)

Gene RIFs: 103   (req: <= 3)

Antibodies: 540   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 55.04   (req: >= 5)

Gene RIFs: 103   (req: > 3)

Antibodies: 540   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0