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Tbio
ROR1
Inactive tyrosine-protein kinase transmembrane receptor ROR1

Protein Summary
Description
Has very low kinase activity in vitro and is unlikely to function as a tyrosine kinase in vivo (PubMed:25029443). Receptor for ligand WNT5A which activate downstream NFkB signaling pathway and may result in the inhibition of WNT3A-mediated signaling (PubMed:25029443, PubMed:27162350). In inner ear, crucial for spiral ganglion neurons to innervate auditory hair cells (PubMed:27162350). This gene encodes a receptor tyrosine kinase-like orphan receptor that modulates neurite growth in the central nervous system. The encoded protein is a glycosylated type I membrane protein that belongs to the ROR subfamily of cell surface receptors. It is a pseudokinase that lacks catalytic activity and may interact with the non-canonical Wnt signalling pathway. This gene is highly expressed during early embryonic development but expressed at very low levels in adult tissues. Increased expression of this gene is associated with B-cell chronic lymphocytic leukaemia. Alternative splicing results in multiple ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000371079
  • ENSP00000360120
  • ENSG00000185483
  • ENST00000371080
  • ENSP00000360121

Symbol
  • NTRKR1
  • NTRKR1
  • dJ537F10.1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
molecular function
0.98
trait
0.97
PubMedID
0.84
transcription factor binding site profile
0.78


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 51.99   (req: < 5)
Gene RIFs: 68   (req: <= 3)
Antibodies: 540   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 51.99   (req: >= 5)
Gene RIFs: 68   (req: > 3)
Antibodies: 540   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
ProKinO
Thumbnail image for ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (54)
SERPINB13
Tbio
Novelty:  0.01753451
p_int:  0.999996804
p_ni:  0.00000311
p_wrong:  8.5e-8
Score:  0.29
Data Source:  BioPlex,STRINGDB
CLEC4A
Tbio
Novelty:  0.01821643
p_int:  0.999992905
p_ni:  0.00000698
p_wrong:  1.14e-7
Data Source:  BioPlex
WNT5A
Tbio
Novelty:  0.00125563
Score:  0.985
Data Source:  STRINGDB
FZD2
Tbio
Family:  GPCR
Novelty:  0.00774893
Score:  0.95
Data Source:  STRINGDB
FZD5
Tbio
Family:  GPCR
Novelty:  0.01673829
Score:  0.947
Data Source:  STRINGDB
ROR2
Tbio
Family:  Kinase
Novelty:  0.01698587
Score:  0.906
Data Source:  STRINGDB
AP2B1
Tbio
Novelty:  0.00921093
Score:  0.904
Data Source:  STRINGDB
AP2A1
Tbio
Novelty:  0.08554974
Score:  0.903
Data Source:  STRINGDB
AP2A2
Tbio
Novelty:  0.08851191
Score:  0.903
Data Source:  STRINGDB
AP2S1
Tbio
Novelty:  0.01931502
Score:  0.902
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (19)
Beta-catenin independent WNT signaling (R-HSA-3858494)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Beta-catenin independent WNT signaling
Reactome
PCP/CE pathway
Reactome
Signal Transduction
Reactome
Signaling by WNT
Reactome
WNT5A-dependent internalization of FZD2, FZD5 and ROR2
Name
Explore in Pharos
Explore in Source
Beta-catenin independent WNT signaling
PCP/CE pathway
Signal Transduction
Signaling by WNT
WNT5A-dependent internalization of FZD2, FZD5 and ROR2
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (24)
Find Similar Targets
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
ParkinsonsUK-UCL
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations ()
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
1
1
1
40.7
1
1
0
1.6
21.5
cortical surface area measurement
1
1
0
32.9
6.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
1
40.7
0
1.6
21.5
cortical surface area measurement
0
32.9
6.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
receptor tyrosine kinase like orphan receptor 1
700760
Mouse
MGI:1347520
26563
Rat
RGD:1559469
362550
Dog
receptor tyrosine kinase like orphan receptor 1
VGNC:45693
489557
Horse
receptor tyrosine kinase like orphan receptor 1
VGNC:22502
100069962
Species
Name
OMA
EggNOG
Inparanoid
Macaque
receptor tyrosine kinase like orphan receptor 1
Mouse
Rat
Dog
receptor tyrosine kinase like orphan receptor 1
Horse
receptor tyrosine kinase like orphan receptor 1
Publication Statistics
PubMed Score 51.99
PubMed score by year
PubTator Score 118.56
PubTator score by year
Patents
Patents by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title