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Tbio
OCRL
Inositol polyphosphate 5-phosphatase OCRL-1

Protein Summary
Description
Converts phosphatidylinositol 4,5-bisphosphate to phosphatidylinositol 4-phosphate. Also converts inositol 1,4,5-trisphosphate to inositol 1,4-bisphosphate and inositol 1,3,4,5-tetrakisphosphate to inositol 1,3,4-trisphosphate (PubMed:25869668, PubMed:7761412, PubMed:9430698). May function in lysosomal membrane trafficking by regulating the specific pool of phosphatidylinositol 4,5-bisphosphate that is associated with lysosomes. Involved in primary cilia assembly (PubMed:22228094, PubMed:22543976). This gene encodes an inositol polyphosphate 5-phosphatase. This protein is involved in regulating membrane trafficking and is located in numerous subcellular locations including the trans-Golgi network, clathrin-coated vesicles and, endosomes and the plasma membrane. This protein may also play a role in primary cilium formation. Mutations in this gene cause oculocerebrorenal syndrome of Lowe and also Dent disease. Alternate splicing results in multiple transcript variants. [provided by RefSe ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000357121
  • ENSP00000349635
  • ENSG00000122126
  • ENST00000371113
  • ENSP00000360154

Symbol
  • INPP5F
  • OCRL1
  • LOCR
  • NPHL2
  • OCRL1
  • INPP5F
  • OCRL-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.85
molecular function
0.84
cellular component
0.79
microRNA
0.71
tissue sample
0.7


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
View Data
 GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 200.78   (req: < 5)
View Publications
Gene RIFs: 60   (req: <= 3)
View Gene RIFs
Antibodies: 337   (req: <= 50)
View Antibodies
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 200.78   (req: >= 5)
Gene RIFs: 60   (req: > 3)
Antibodies: 337   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 19
View GO Terms
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (4)
Items per page:
1 – 4 of 4
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
Diarrhea
HP_0002014
1
1
0
4.1
2.3
coronary artery disease
EFO_0001645
1
1
0
4.1
2.3
response to darapladib
EFO_0008395
1
1
0
4.1
2.3
acute coronary syndrome
EFO_0005672
1
1
0
4.1
2.3
Items per page:
1 – 4 of 4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
Diarrhea
HP_0002014
0
4.1
2.3
coronary artery disease
EFO_0001645
0
4.1
2.3
response to darapladib
EFO_0008395
0
4.1
2.3
acute coronary syndrome
EFO_0005672
0
4.1
2.3
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
OCRL, inositol polyphosphate-5-phosphatase
VGNC:10468
465851
Macaque
OCRL, inositol polyphosphate-5-phosphatase
702345
Mouse
OCRL, inositol polyphosphate-5-phosphatase
MGI:109589
320634
Rat
OCRL, inositol polyphosphate-5-phosphatase
RGD:1594526
317576
Dog
OCRL, inositol polyphosphate-5-phosphatase
VGNC:44095
492123
Species
Name
OMA
EggNOG
Inparanoid
Chimp
OCRL, inositol polyphosphate-5-phosphatase
Macaque
OCRL, inositol polyphosphate-5-phosphatase
Mouse
OCRL, inositol polyphosphate-5-phosphatase
Rat
OCRL, inositol polyphosphate-5-phosphatase
Dog
OCRL, inositol polyphosphate-5-phosphatase
Protein Structure (5 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q01968-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 5
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (27)
Clathrin-mediated endocytosis (R-HSA-8856828)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 17
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Clathrin-mediated endocytosis
143 targets
R-HSA-8856828
Reactome
Golgi Associated Vesicle Biogenesis
56 targets
R-HSA-432722
Reactome
Inositol phosphate metabolism
48 targets
R-HSA-1483249
Reactome
Membrane Trafficking
612 targets
R-HSA-199991
Reactome
Metabolism
2112 targets
R-HSA-1430728
Name
Explore in Pharos
Explore in Source
Clathrin-mediated endocytosis
143 targets
R-HSA-8856828
Golgi Associated Vesicle Biogenesis
56 targets
R-HSA-432722
Inositol phosphate metabolism
48 targets
R-HSA-1483249
Membrane Trafficking
612 targets
R-HSA-199991
Metabolism
2112 targets
R-HSA-1430728
Gene Ontology Terms (33)
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
GTPase activator activity
Inferred from Direct Assay (IDA)
FlyBase
inositol phosphate phosphatase activity
Inferred from Direct Assay (IDA)
UniProtKB
Rac GTPase binding
Inferred from Physical Interaction (IPI)
FlyBase
phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity
Traceable Author Statement (TAS)
Reactome
inositol-1,4,5-trisphosphate 5-phosphatase activity
Traceable Author Statement (TAS)
Reactome
phosphatidylinositol phosphate 4-phosphatase activity
Traceable Author Statement (TAS)
Reactome
phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity
Traceable Author Statement (TAS)
Reactome
Protein-Protein Interactions (295)
1 – 10 of 295
PHETA1
Tbio
Novelty: 0.52415295
p_int: 0.999988829
p_ni: 0.000011171
Score: 0.995
Data Source: BioPlex,STRINGDB
PHETA2
Tbio
Novelty: 2.16796164
p_int: 0.999966344
p_ni: 0.000033656
Score: 0.933
Data Source: BioPlex,STRINGDB
INPP5B
Tbio
Family: Enzyme
Novelty: 0.02981249
p_int: 0.998935319
p_ni: 6.8e-7
p_wrong: 0.001064001
Score: 0.971
Data Source: BioPlex,STRINGDB
PLEKHJ1
Tdark
Novelty: 1.44399298
p_int: 0.994843243
p_ni: 0.005156708
p_wrong: 4.9e-8
Score: 0.874
Data Source: BioPlex,STRINGDB
PAK2
Tchem
Family: Kinase
Novelty: 0.0149123
p_int: 0.993284146
p_ni: 0.005605052
p_wrong: 0.001110803
Score: 0.427
Data Source: BioPlex,STRINGDB
TPCN2
Tchem
Family: IC
Novelty: 0.01351129
p_int: 0.962878661
p_ni: 0.037121339
Data Source: BioPlex
AP2A1
Tbio
Novelty: 0.08554974
p_int: 0.961152231
p_ni: 0.038847769
Score: 0.965
Data Source: BioPlex,STRINGDB
C16orf70
Tdark
Novelty: 2.12573065
p_int: 0.957538145
p_ni: 0.042461855
Data Source: BioPlex
RAB6A
Tbio
Family: Enzyme
Novelty: 0.00546034
p_int: 0.942028841
p_ni: 0.057971158
p_wrong: 1e-9
Score: 0.923
Data Source: BioPlex,STRINGDB
PCBP3
Tbio
Novelty: 0.11681812
p_int: 0.898401662
p_ni: 0.101488639
p_wrong: 0.000109699
Data Source: BioPlex
Publication Statistics
PubMed Score  200.78

PubMed score by year
PubTator Score  169.16

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer