Tbio OCRL Inositol polyphosphate 5-phosphatase OCRL-1

Protein Summary

Description

Converts phosphatidylinositol 4,5-bisphosphate to phosphatidylinositol 4-phosphate. Also converts inositol 1,4,5-trisphosphate to inositol 1,4-bisphosphate and inositol 1,3,4,5-tetrakisphosphate to inositol 1,3,4-trisphosphate (PubMed:25869668, PubMed:7761412, PubMed:9430698). May function in lysosomal membrane trafficking by regulating the specific pool of phosphatidylinositol 4,5-bisphosphate that is associated with lysosomes. Involved in primary cilia assembly (PubMed:22228094, PubMed:22543976). This gene encodes an inositol polyphosphate 5-phosphatase. This protein is involved in regulating membrane trafficking and is located in numerous subcellular locations including the trans-Golgi network, clathrin-coated vesicles and, endosomes and the plasma membrane. This protein may also play a role in primary cilium formation. Mutations in this gene cause oculocerebrorenal syndrome of Lowe and also Dent disease. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]

Uniprot Accession IDs

• Q01968
• A6NKI1
• A8KAP2
• B7ZLX2
• O60800
• Q15684
• Q15774
• Q4VY09
• Q4VY10
• Q5JQF1
• Q5JQF2
• Q9UJG5
• Q9UMA5

Gene Name

• OCRL

Ensembl ID

• ENST00000357121
• ENSP00000349635
• ENSG00000122126
• ENST00000371113
• ENSP00000360154

Symbol

• INPP5F
• OCRL1
• LOCR
• NPHL2
• OCRL1
• INPP5F
• OCRL-1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
virus perturbation	0.85
molecular function	0.84
cellular component	0.79
microRNA	0.71
tissue sample	0.7

Protein Classes

PANTHER Classes

Protein / Hydrolase / Phosphatase / Inositol Polyphosphate 5-phosphatase Ocrl-1

DTO Classes

Protein / Enzyme / Hydrolase / Phosphatase / Inositol Polyphosphate 5-phosphatase Ocrl-1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 238.48   (req: < 5)

Gene RIFs: 77   (req: <= 3)

Antibodies: 337   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 238.48   (req: >= 5)

Gene RIFs: 77   (req: > 3)

Antibodies: 337   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 19

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0