SLC6A3
Sodium-dependent dopamine transporter
Protein Summary
Amine transporter. Terminates the action of dopamine by its high affinity sodium-dependent reuptake into presynaptic terminals. This gene encodes a dopamine transporter which is a member of the sodium- and chloride-dependent neurotransmitter transporter family. The 3' UTR of this gene contains a 40 bp tandem repeat, referred to as a variable number tandem repeat or VNTR, which can be present in 3 to 11 copies. Variation in the number of repeats is associated with idiopathic epilepsy, attention-deficit hyperactivity disorder, dependence on alcohol and cocaine, susceptibility to Parkinson disease and protection against nicotine dependence.[provided by RefSeq, Nov 2009]
- ENST00000270349
- ENSP00000270349
- ENSG00000142319
- ENST00000621716
- ENSP00000479597
- ENSG00000276996
- DAT1
- DAT
- DAT1
- PKDYS
- PKDYS1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
drug | 1 | ||
molecular function | 0.99 | ||
chemical | 0.97 | ||
gene perturbation | 0.92 | ||
biological process | 0.89 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 6214.65 (req: < 5)
Gene RIFs: 641 (req: <= 3)
Antibodies: 410 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 6214.65 (req: >= 5)
Gene RIFs: 641 (req: > 3)
Antibodies: 410 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 30
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 1842
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drugs: 49