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Tclin
SLC6A3
Sodium-dependent dopamine transporter

Protein Summary
Description
Amine transporter. Terminates the action of dopamine by its high affinity sodium-dependent reuptake into presynaptic terminals. This gene encodes a dopamine transporter which is a member of the sodium- and chloride-dependent neurotransmitter transporter family. The 3' UTR of this gene contains a 40 bp tandem repeat, referred to as a variable number tandem repeat or VNTR, which can be present in 3 to 11 copies. Variation in the number of repeats is associated with idiopathic epilepsy, attention-deficit hyperactivity disorder, dependence on alcohol and cocaine, susceptibility to Parkinson disease and protection against nicotine dependence.[provided by RefSeq, Nov 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000270349
  • ENSP00000270349
  • ENSG00000142319
  • ENST00000621716
  • ENSP00000479597
  • ENSG00000276996

Symbol
  • DAT1
  • DAT
  • DAT1
  • PKDYS
  • PKDYS1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
drug
1
molecular function
0.99
chemical
0.97
gene perturbation
0.92
biological process
0.89


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5747.27   (req: < 5)
Gene RIFs: 575   (req: <= 3)
Antibodies: 410   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5747.27   (req: >= 5)
Gene RIFs: 575   (req: > 3)
Antibodies: 410   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 30
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 1827
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 48
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (5)
RESOLUTE
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RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
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ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (48)
clemastine
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metergoline
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carvedilol
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clomipramine
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benzatropine
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astemizole
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flunarizine
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econazole
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paroxetine
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phenelzine
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Active Ligands (1827)
CHEMBL4128926
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CHEMBL199824
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CHEMBL3752900
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NPS 2143
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CHEMBL486278
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CHEMBL3321792
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CHEMBL3321791
Rendered image for CHEMBL3321791
CHEMBL1940403
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CHEMBL2203406
Rendered image for CHEMBL2203406
Protein-Protein Interactions (147)
DRD2
Tclin
Family:  GPCR
Novelty:  0.00033797
Score:  0.99
Data Source:  STRINGDB
SNCA
Tchem
Novelty:  0.00012042
Score:  0.983
Data Source:  STRINGDB
SLC18A2
Tclin
Family:  Transporter
Novelty:  0.00072341
Score:  0.954
Data Source:  STRINGDB
STX1A
Tbio
Novelty:  0.00087207
Score:  0.952
Data Source:  STRINGDB
TH
Tclin
Family:  Enzyme
Novelty:  0.00025719
Score:  0.928
Data Source:  STRINGDB
FLOT1
Tbio
Novelty:  0.00504569
Score:  0.919
Data Source:  STRINGDB
FLOT2
Tbio
Novelty:  0.00727325
Score:  0.903
Data Source:  STRINGDB
CDH1
Tbio
Novelty:  0.00010629
Score:  0.902
Data Source:  STRINGDB
DRD4
Tchem
Family:  GPCR
Novelty:  0.00099622
Score:  0.898
Data Source:  STRINGDB
DRD1
Tclin
Family:  GPCR
Novelty:  0.00165886
Score:  0.892
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (27)
Defective SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS) (R-HSA-5619081)

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Find Similar Targets
Items per page:
1 – 5 of 12
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Defective SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS)
Reactome
Disease
Reactome
Disorders of transmembrane transporters
Reactome
Dopamine clearance from the synaptic cleft
Reactome
Na+/Cl- dependent neurotransmitter transporters
Name
Explore in Pharos
Explore in Source
Defective SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS)
Disease
Disorders of transmembrane transporters
Dopamine clearance from the synaptic cleft
Na+/Cl- dependent neurotransmitter transporters
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (42)
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Items per page:
10
1 – 10 of 10
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
MGI
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations (null)
No disease associations found
GWAS Traits (56)
Items per page:
1 – 5 of 56
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
6
3
1
1.2
96.2
6
3
1
1.2
96.2
5
4
0
1.1
93.8
5
4
0
1.1
93.8
1
2
0
1.1
86
Items per page:
1 – 5 of 56
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1.2
96.2
1
1.2
96.2
0
1.1
93.8
0
1.1
93.8
0
1.1
86
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 6 member 3
VGNC:50806
750842
Macaque
solute carrier family 6 member 3
574143
Mouse
MGI:94862
13162
Rat
RGD:3715
24898
Dog
solute carrier family 6 member 3
VGNC:46464
609304
Species
Name
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 6 member 3
Macaque
solute carrier family 6 member 3
Mouse
Rat
Dog
solute carrier family 6 member 3
Publication Statistics
PubMed Score 5747.27
PubMed score by year
PubTator Score 3176.87
PubTator score by year
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Related Publications
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0 of 0
PMID
Year
Title