Tbio POU5F1 POU domain, class 5, transcription factor 1

Protein Summary

Description

Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3'). Forms a trimeric complex with SOX2 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206. Critical for early embryogenesis and for embryonic stem cell pluripotency. This gene encodes a transcription factor containing a POU homeodomain that plays a key role in embryonic development and stem cell pluripotency. Aberrant expression of this gene in adult tissues is associated with tumorigenesis. This gene can participate in a translocation with the Ewing's sarcoma gene on chromosome 21, which also leads to tumor formation. Alternative splicing, as well as usage of alternative AUG and non-AUG translation initiation codons, results in multiple isoforms. One of the AUG start codons is polymorphic in human populations. Related pseudogenes have been identified on chromosomes 1, 3, 8, 10, and 12. [provided by RefSeq, Oct 2013]

Uniprot Accession IDs

• Q01860
• A6NCS1
• A6NLL8
• D2IYK4
• P31359
• Q15167
• Q15168
• Q16422
• Q5STF3
• Q5STF4

Gene Name

• POU5F1

Ensembl ID

• ENST00000259915
• ENSP00000259915
• ENSG00000204531
• ENST00000376243
• ENSP00000365419
• ENSG00000206454
• ENST00000383524
• ENSP00000373016
• ENST00000412166
• ENSP00000387646
• ENSG00000229094
• ENST00000419095
• ENSP00000413622
• ENSG00000235068
• ENST00000429314
• ENSP00000387619
• ENSG00000237582
• ENST00000429603
• ENSP00000392877
• ENSG00000233911
• ENST00000433063
• ENSP00000405041
• ENST00000433348
• ENSP00000412665
• ENSG00000230336
• ENST00000434616
• ENSP00000388842
• ENST00000437747
• ENSP00000391681
• ENST00000451077
• ENSP00000391507
• ENST00000454714
• ENSP00000400047

Symbol

• OCT3
• OCT4
• OTF3
• OCT3
• OCT4
• OTF3
• OTF4
• OTF-3
• Oct-3
• Oct-4

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
virus	0.98
viral protein	0.93
protein domain	0.92
disease	0.79
PubMedID	0.78

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3593.36   (req: < 5)

Gene RIFs: 597   (req: <= 3)

Antibodies: 1330   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3593.36   (req: >= 5)

Gene RIFs: 597   (req: > 3)

Antibodies: 1330   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 31

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0