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Tbio
POU5F1
POU domain, class 5, transcription factor 1

Protein Summary
Description
Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3'). Forms a trimeric complex with SOX2 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206. Critical for early embryogenesis and for embryonic stem cell pluripotency. This gene encodes a transcription factor containing a POU homeodomain that plays a key role in embryonic development and stem cell pluripotency. Aberrant expression of this gene in adult tissues is associated with tumorigenesis. This gene can participate in a translocation with the Ewing's sarcoma gene on chromosome 21, which also leads to tumor formation. Alternative splicing, as well as usage of alternative AUG and non-AUG translation initiation codons, results in multiple isoforms. One of the AUG start codons is polymorphic in human populations. Related pseudogenes have been identified on chromosomes 1, 3, 8, 10, and 12. [provided by RefSeq, Oct 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000259915
  • ENSP00000259915
  • ENSG00000204531
  • ENST00000376243
  • ENSP00000365419
  • ENSG00000206454
  • ENST00000383524
  • ENSP00000373016
  • ENST00000412166
  • ENSP00000387646
  • ENSG00000229094
  • ENST00000419095
  • ENSP00000413622
  • ENSG00000235068
  • ENST00000429314
  • ENSP00000387619
  • ENSG00000237582
  • ENST00000429603
  • ENSP00000392877
  • ENSG00000233911
  • ENST00000433063
  • ENSP00000405041
  • ENST00000433348
  • ENSP00000412665
  • ENSG00000230336
  • ENST00000434616
  • ENSP00000388842
  • ENST00000437747
  • ENSP00000391681
  • ENST00000451077
  • ENSP00000391507
  • ENST00000454714
  • ENSP00000400047

Symbol
  • OCT3
  • OCT4
  • OTF3
  • OCT3
  • OCT4
  • OTF3
  • OTF4
  • OTF-3
  • Oct-3
  • Oct-4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus
0.98
viral protein
0.93
protein domain
0.92
disease
0.79
PubMedID
0.78


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2330.04   (req: < 5)
View Publications
Gene RIFs: 483   (req: <= 3)
View Gene RIFs
Antibodies: 1330   (req: <= 50)
View Antibodies
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2330.04   (req: >= 5)
Gene RIFs: 483   (req: > 3)
Antibodies: 1330   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 31
View GO Terms
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Pathways (14)
Developmental Biology (R-HSA-1266738)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Developmental Biology
1055 targets
R-HSA-1266738
Reactome
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation
13 targets
R-HSA-2892247
Reactome
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation
10 targets
R-HSA-2892245
Reactome
Transcriptional regulation of pluripotent stem cells
31 targets
R-HSA-452723
Name
Explore in Pharos
Explore in Source
Developmental Biology
1055 targets
R-HSA-1266738
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation
13 targets
R-HSA-2892247
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation
10 targets
R-HSA-2892245
Transcriptional regulation of pluripotent stem cells
31 targets
R-HSA-452723
Gene Ontology Terms (37)
Items per page:
10
1 – 10 of 11
GO Term
Evidence
Assigned by
DNA binding
Inferred from Direct Assay (IDA)
HGNC
DNA-binding transcription factor activity
Inferred from Direct Assay (IDA)
HGNC
DNA-binding transcription repressor activity, RNA polymerase II-specific
Inferred from Direct Assay (IDA)
BHF-UCL
miRNA binding
Inferred from Direct Assay (IDA)
UniProtKB
sequence-specific DNA binding
Inferred from Direct Assay (IDA)
MGI
transcription regulatory region DNA binding
Inferred from Direct Assay (IDA)
BHF-UCL
transcription regulatory region sequence-specific DNA binding
Inferred from Direct Assay (IDA)
BHF-UCL
transcription factor binding
Inferred from Physical Interaction (IPI)
BHF-UCL
ubiquitin protein ligase binding
Inferred from Physical Interaction (IPI)
BHF-UCL
RNA binding
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Protein-Protein Interactions (445)
1 – 10 of 445
SOX2
Tbio
Family: TF
Novelty: 0.00050367
Score: 0.999
Data Source: Reactome,STRINGDB
NANOG
Tbio
Family: TF
Novelty: 0.00073323
Score: 0.999
Data Source: Reactome,STRINGDB
LIN28A
Tbio
Family: TF
Novelty: 0.00264555
Score: 0.996
Data Source: STRINGDB
KLF4
Tbio
Family: TF
Novelty: 0.00109098
Score: 0.994
Data Source: STRINGDB
SALL4
Tbio
Family: TF
Novelty: 0.00211387
Score: 0.994
Data Source: STRINGDB
TDGF1
Tbio
Novelty: 0.00598943
Score: 0.987
Data Source: STRINGDB
FOXD3
Tbio
Family: TF
Novelty: 0.00191678
Score: 0.984
Data Source: STRINGDB
FGF2
Tchem
Novelty: 0.00009754
Score: 0.979
Data Source: STRINGDB
DPPA4
Tbio
Novelty: 0.09606623
Score: 0.975
Data Source: STRINGDB
PRDM14
Tbio
Family: TF; Epigenetic
Novelty: 0.02121506
Score: 0.973
Data Source: STRINGDB
Publication Statistics
PubMed Score  2330.04

PubMed score by year
PubTator Score  2141.86

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer