Tbio POU5F1 POU domain, class 5, transcription factor 1

Protein Summary

Description

Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3'). Forms a trimeric complex with SOX2 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206. Critical for early embryogenesis and for embryonic stem cell pluripotency. This gene encodes a transcription factor containing a POU homeodomain that plays a key role in embryonic development and stem cell pluripotency. Aberrant expression of this gene in adult tissues is associated with tumorigenesis. This gene can participate in a translocation with the Ewing's sarcoma gene on chromosome 21, which also leads to tumor formation. Alternative splicing, as well as usage of alternative AUG and non-AUG translation initiation codons, results in multiple isoforms. One of the AUG start codons is polymorphic in human populations. Related pseudogenes have been identified on chromosomes 1, 3, 8, 10, and 12. [provided by RefSeq, Oct 2013]

Uniprot Accession IDs

• Q01860
• A6NCS1
• A6NLL8
• D2IYK4
• P31359
• Q15167
• Q15168
• Q16422
• Q5STF3
• Q5STF4

Gene Name

• POU5F1

Ensembl ID

• ENST00000259915
• ENSP00000259915
• ENSG00000204531
• ENST00000376243
• ENSP00000365419
• ENSG00000206454
• ENST00000383524
• ENSP00000373016
• ENST00000412166
• ENSP00000387646
• ENSG00000229094
• ENST00000419095
• ENSP00000413622
• ENSG00000235068
• ENST00000429314
• ENSP00000387619
• ENSG00000237582
• ENST00000429603
• ENSP00000392877
• ENSG00000233911
• ENST00000433063
• ENSP00000405041
• ENST00000433348
• ENSP00000412665
• ENSG00000230336
• ENST00000434616
• ENSP00000388842
• ENST00000437747
• ENSP00000391681
• ENST00000451077
• ENSP00000391507
• ENST00000454714
• ENSP00000400047

Symbol

• OCT3
• OCT4
• OTF3
• OCT3
• OCT4
• OTF3
• OTF4
• OTF-3
• Oct-3
• Oct-4

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
virus	0.98
viral protein	0.93
protein domain	0.92
disease	0.79
PubMedID	0.78

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3178.45   (req: < 5)

Gene RIFs: 483   (req: <= 3)

Antibodies: 1330   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3178.45   (req: >= 5)

Gene RIFs: 483   (req: > 3)

Antibodies: 1330   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 31

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

GWAS Traits (58)

Items per page:

5

1 – 5 of 58

GWAS Trait	EFO ID	ENSG ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
psoriatic arthritis	EFO_0003778	ENSG00000233911	1	1	0	11.6	96.2
psoriatic arthritis	EFO_0003778	ENSG00000230336	1	1	0	11.6	96.2
psoriatic arthritis	EFO_0003778	ENSG00000229094	1	1	0	11.6	96.2
psoriatic arthritis	EFO_0003778	ENSG00000206454	1	1	0	11.6	96.2
psoriatic arthritis	EFO_0003778	ENSG00000204531	1	1	0	11.6	96.2

Items per page:

5

1 – 5 of 58

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
psoriatic arthritis	EFO_0003778	0	11.6	96.2
psoriatic arthritis	EFO_0003778	0	11.6	96.2
psoriatic arthritis	EFO_0003778	0	11.6	96.2
psoriatic arthritis	EFO_0003778	0	11.6	96.2
psoriatic arthritis	EFO_0003778	0	11.6	96.2

Reset Zoom  Beta Count   Odds Ratio

Orthologs (2)

1 – 2 of 2

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	POU class 5 homeobox 1		744263
Macaque	POU class 5 homeobox 1		714760

Species	Name	OMA	EggNOG	Inparanoid
Chimp	POU class 5 homeobox 1
Macaque	POU class 5 homeobox 1

Protein Structure (0 Structures, 1 AlphaFold Model)

Representation

  axes   backbone   ball+stick   cartoon   rocket   rope   spacefill

Color Scheme

  target   atomindex   bfactor   chainname   electrostatic   element   hydrophobicity   resname   sstruc

AF-Q01860-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (14)

Reactome (4)

KEGG (1)

PathwayCommons (1)

WikiPathways (8)

Developmental Biology (R-HSA-1266738)

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Find Similar Targets

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5

1 – 4 of 4

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Developmental Biology	1055 targets	R-HSA-1266738
Reactome	POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation	13 targets	R-HSA-2892247
Reactome	POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation	10 targets	R-HSA-2892245
Reactome	Transcriptional regulation of pluripotent stem cells	31 targets	R-HSA-452723

Name	Explore in Pharos	Explore in Source
Developmental Biology	1055 targets	R-HSA-1266738
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation	13 targets	R-HSA-2892247
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation	10 targets	R-HSA-2892245
Transcriptional regulation of pluripotent stem cells	31 targets	R-HSA-452723

Gene Ontology Terms (37)

Functions (11)

Components (6)

Processes (20)

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Items per page:

10

1 – 10 of 11

GO Term	Evidence	Assigned by
DNA binding	Inferred from Direct Assay (IDA)	HGNC
DNA-binding transcription factor activity	Inferred from Direct Assay (IDA)	HGNC
DNA-binding transcription repressor activity, RNA polymerase II-specific	Inferred from Direct Assay (IDA)	BHF-UCL
miRNA binding	Inferred from Direct Assay (IDA)	UniProtKB
sequence-specific DNA binding	Inferred from Direct Assay (IDA)	MGI
transcription regulatory region DNA binding	Inferred from Direct Assay (IDA)	BHF-UCL
transcription regulatory region sequence-specific DNA binding	Inferred from Direct Assay (IDA)	BHF-UCL
transcription factor binding	Inferred from Physical Interaction (IPI)	BHF-UCL
ubiquitin protein ligase binding	Inferred from Physical Interaction (IPI)	BHF-UCL
RNA binding	Inferred from High Throughput Direct Assay (HDA)	UniProtKB

Protein-Protein Interactions (445)

Explore Interacting Targets

1 – 10 of 445

• See Interactions on String-DB

SOX2

Tbio

Family: TF

Novelty: 0.00037089

Score: 0.999

Data Source: Reactome,STRINGDB

NANOG

Tbio

Family: TF

Novelty: 0.00054893

Score: 0.999

Data Source: Reactome,STRINGDB

LIN28A

Tbio

Family: TF

Novelty: 0.00199524

Score: 0.996

Data Source: STRINGDB

KLF4

Tbio

Family: TF

Novelty: 0.00076828

Score: 0.994

Data Source: STRINGDB

SALL4

Tbio

Family: TF

Novelty: 0.00354374

Score: 0.994

Data Source: STRINGDB

TDGF1

Tbio

Novelty: 0.00527099

Score: 0.987

Data Source: STRINGDB

FOXD3

Tbio

Family: TF

Novelty: 0.00550321

Score: 0.984

Data Source: STRINGDB

FGF2

Tchem

Novelty: 0.00007856

Score: 0.979

Data Source: STRINGDB

DPPA4

Tbio

Novelty: 0.05764302

Score: 0.975

Data Source: STRINGDB

PRDM14

Tbio

Family: TF; Epigenetic

Novelty: 0.01776592

Score: 0.973

Data Source: STRINGDB

Publication Statistics

PubMed Score  3178.45

PubMed score by year

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PubTator Score  2141.86

PubTator score by year

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Amino Acid Sequence

Residue Counts

Protein Sequence

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UniProt Keyword Find Similar Targets

Alternative splicing
Complete proteome
Cytoplasm
Developmental protein
DNA-binding
Homeobox
Isopeptide bond
Nucleus
Phosphoprotein
Polymorphism

GWAS Trait Find Similar Targets

hemoglobin measurement
HIV-1 infection
lymphocyte count
mean platelet volume
membranous glomerulonephritis
monocyte percentage of leukocytes
parental longevity
psoriasis
psoriatic arthritis
reticulocyte measurement

MGI Phenotype Find Similar Targets

cellular phenotype
embryo phenotype
endocrine/exocrine gland phenotype
mortality/aging
reproductive system phenotype