POU5F1
POU domain, class 5, transcription factor 1
Protein Summary
Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3'). Forms a trimeric complex with SOX2 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206. Critical for early embryogenesis and for embryonic stem cell pluripotency. This gene encodes a transcription factor containing a POU homeodomain that plays a key role in embryonic development and stem cell pluripotency. Aberrant expression of this gene in adult tissues is associated with tumorigenesis. This gene can participate in a translocation with the Ewing's sarcoma gene on chromosome 21, which also leads to tumor formation. Alternative splicing, as well as usage of alternative AUG and non-AUG translation initiation codons, results in multiple isoforms. One of the AUG start codons is polymorphic in human populations. Related pseudogenes have been identified on chromosomes 1, 3, 8, 10, and 12. [provided by RefSeq, Oct 2013]
- ENST00000259915
- ENSP00000259915
- ENSG00000204531
- ENST00000376243
- ENSP00000365419
- ENSG00000206454
- ENST00000383524
- ENSP00000373016
- ENST00000412166
- ENSP00000387646
- ENSG00000229094
- ENST00000419095
- ENSP00000413622
- ENSG00000235068
- ENST00000429314
- ENSP00000387619
- ENSG00000237582
- ENST00000429603
- ENSP00000392877
- ENSG00000233911
- ENST00000433063
- ENSP00000405041
- ENST00000433348
- ENSP00000412665
- ENSG00000230336
- ENST00000434616
- ENSP00000388842
- ENST00000437747
- ENSP00000391681
- ENST00000451077
- ENSP00000391507
- ENST00000454714
- ENSP00000400047
- OCT3
- OCT4
- OTF3
- OCT3
- OCT4
- OTF3
- OTF4
- OTF-3
- Oct-3
- Oct-4
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
virus | 0.98 | ||
viral protein | 0.93 | ||
protein domain | 0.92 | ||
disease | 0.79 | ||
PubMedID | 0.78 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 3258.01 (req: < 5)
Gene RIFs: 483 (req: <= 3)
Antibodies: 1330 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 3258.01 (req: >= 5)
Gene RIFs: 483 (req: > 3)
Antibodies: 1330 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 31
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (445)
Nearest Tclin Targets (2)
Upstream (2)
1 – 2 of 2
Pathways (14)
Reactome (4)
KEGG (1)
PathwayCommons (1)
WikiPathways (8)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Developmental Biology | ||||
Reactome | POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation | ||||
Reactome | POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation | ||||
Reactome | Transcriptional regulation of pluripotent stem cells | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Developmental Biology | ||||
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation | ||||
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation | ||||
Transcriptional regulation of pluripotent stem cells | ||||
Viral Interactions (0)
Gene Ontology Terms (37)
Functions (11)
Components (6)
Processes (20)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | HGNC | |||
Inferred from Direct Assay (IDA) | HGNC | |||
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | MGI | |||
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Physical Interaction (IPI) | BHF-UCL | |||
Inferred from Physical Interaction (IPI) | BHF-UCL | |||
Inferred from High Throughput Direct Assay (HDA) | UniProtKB | |||
Disease Associations ()
GWAS Traits (714)
Items per page:
1 – 5 of 714
GWAS Trait | EFO ID | ENSG ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|---|
leukocyte count | 9 | 9 | 13 | 99.4 | ||||||
leukocyte count | 9 | 9 | 13 | 99.4 | ||||||
leukocyte count | 9 | 9 | 13 | 99.4 | ||||||
leukocyte count | 9 | 9 | 13 | 99.4 | ||||||
leukocyte count | 9 | 9 | 13 | 99.4 | ||||||
Items per page:
1 – 5 of 714
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
leukocyte count | 13 | 99.4 | |||||
leukocyte count | 13 | 99.4 | |||||
leukocyte count | 13 | 99.4 | |||||
leukocyte count | 13 | 99.4 | |||||
leukocyte count | 13 | 99.4 | |||||
Find similar targets by:
IDG Resources
Orthologs (2)
1 – 2 of 2
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | POU class 5 homeobox 1 | 744263 | ||||||
Macaque | POU class 5 homeobox 1 | 714760 | ||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | POU class 5 homeobox 1 | |||||
Macaque | POU class 5 homeobox 1 | |||||
Publication Statistics
PubMed Score 3258.01
PubMed score by year
PubTator Score 2141.86
PubTator score by year
Related Publications
Text Mined References (539)
GeneRif Annotations (483)
Items per page:
0 of 0
PMID | Year | Title |
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