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Tbio
EWSR1
RNA-binding protein EWS

Protein Summary
Description
Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes. This gene encodes a multifunctional protein that is involved in various cellular processes, including gene expression, cell signaling, and RNA processing and transport. The protein includes an N-terminal transcriptional activation domain and a C-terminal RNA-binding domain. Chromosomal translocations between this gene and various genes encoding transcription factors result in the production of chimeric proteins that are involved in tumorigenesis. These chimeric proteins usually consist of the N-terminal transcriptional activation domain of this protein fused to the C-terminal DNA-binding domain of the transcription factor protein. Mu ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000332035
  • ENSP00000331699
  • ENSG00000182944
  • ENST00000333395
  • ENSP00000327456
  • ENST00000397938
  • ENSP00000381031
  • ENST00000406548
  • ENSP00000385726
  • ENST00000414183
  • ENSP00000400142

Symbol
  • EWS
  • EWS
  • EWS-FLI1
  • bK984G1.4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
1
hub protein
0.99
kinase
0.95
transcription factor binding site profile
0.79
tissue
0.76


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1624.1   (req: < 5)
Gene RIFs: 177   (req: <= 3)
Antibodies: 504   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1624.1   (req: >= 5)
Gene RIFs: 177   (req: > 3)
Antibodies: 504   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet count
1
1
1
16.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet count
1
16.4
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Gene Ontology Terms (9)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
IntAct
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (232)
1 – 10 of 232
SFPQ
Tbio
Novelty: 0.01207637
p_int: 0.998663764
p_ni: 0.001336236
Score: 0.61
Data Source: BioPlex,STRINGDB
PRMT8
Tchem
Family: Epigenetic
Novelty: 0.04213384
p_int: 0.941844898
p_ni: 0.058155102
Score: 0.463
Data Source: BioPlex,STRINGDB
CAPN13
Tdark
Novelty: 0.27206398
p_int: 0.854608349
p_ni: 0.145391651
Score: 0.199
Data Source: BioPlex,STRINGDB
BARD1
Tbio
Novelty: 0.00513841
Score: 0.95
Data Source: STRINGDB
DHX9
Tbio
Family: Enzyme
Novelty: 0.00130907
Score: 0.928
Data Source: STRINGDB
LMNA
Tbio
Novelty: 0.00046972
Score: 0.846
Data Source: STRINGDB
TP53
Tchem
Family: TF
Novelty: 0.00001907
Score: 0.84
Data Source: STRINGDB
FLII
Tbio
Novelty: 0.00200219
Score: 0.836
Data Source: STRINGDB
TARDBP
Tbio
Novelty: 0.00165455
Score: 0.833
Data Source: STRINGDB
HNRNPA1
Tchem
Novelty: 0.0020871
Score: 0.83
Data Source: STRINGDB
Publication Statistics
PubMed Score  1624.10

PubMed score by year
PubTator Score  851.29

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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