SATB1
DNA-binding protein SATB1
Protein Classes
Protein Summary
Crucial silencing factor contributing to the initiation of X inactivation mediated by Xist RNA that occurs during embryogenesis and in lymphoma (By similarity). Binds to DNA at special AT-rich sequences, the consensus SATB1-binding sequence (CSBS), at nuclear matrix- or scaffold-associated regions. Thought to recognize the sugar-phosphate structure of double-stranded DNA. Transcriptional repressor controlling nuclear and viral gene expression in a phosphorylated and acetylated status-dependent manner, by binding to matrix attachment regions (MARs) of DNA and inducing a local chromatin-loop remodeling. Acts as a docking site for several chromatin remodeling enzymes (e.g. PML at the MHC-I locus) and also by recruiting corepressors (HDACs) or coactivators (HATs) directly to promoters and enhancers. Modulates genes that are essential in the maturation of the immune T-cell CD8SP from thymocytes. Required for the switching of fetal globin species, and beta- and gamma-globin genes regulation ...more
- ENST00000338745
- ENSP00000341024
- ENSG00000182568
- ENST00000417717
- ENSP00000399518
- ENST00000454909
- ENSP00000399708
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
PubMedID | 0.99 | ||
transcription factor perturbation | 0.96 | ||
gene perturbation | 0.92 | ||
biological process | 0.88 | ||
disease perturbation | 0.87 | ||
Related Tools
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 306.65 (req: < 5)
Gene RIFs: 126 (req: <= 3)
Antibodies: 445 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 306.65 (req: >= 5)
Gene RIFs: 126 (req: > 3)
Antibodies: 445 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 16
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Orthologs (11)
1 – 5 of 11
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Macaque | SATB homeobox 1 | 696862 | ||||||
Mouse | MGI:105084 | 20230 | ||||||
Rat | RGD:1305561 | 316164 | ||||||
Dog | SATB homeobox 1 | VGNC:45875 | 485650 | |||||
Horse | SATB homeobox 1 | VGNC:22700 | 100033929 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Macaque | SATB homeobox 1 | |||||
Mouse | ||||||
Rat | ||||||
Dog | SATB homeobox 1 | |||||
Horse | SATB homeobox 1 | |||||
Protein Data Bank (7)
1 – 5 of 7
PDB Structure Id | Ligand | Method | Resolution (Å) | M.W. (kDa) | Pub Year | Title |
|---|
PDB Structure Id | M.W. | Resolution | Pub Year |
|---|
Pathways (20)
Reactome (9)
PathwayCommons (1)
WikiPathways (10)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 5 of 9
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Apoptosis | ||||
Reactome | Apoptotic cleavage of cellular proteins | ||||
Reactome | Apoptotic execution phase | ||||
Reactome | Metabolism of proteins | ||||
Reactome | Post-translational protein modification | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Apoptosis | ||||
Apoptotic cleavage of cellular proteins | ||||
Apoptotic execution phase | ||||
Metabolism of proteins | ||||
Post-translational protein modification | ||||
Gene Ontology Terms (22)
Functions (6)
Components (6)
Processes (10)
Items per page:
10
1 – 6 of 6
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | NTNU_SB | |||
Inferred from Direct Assay (IDA) | NTNU_SB | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Sequence Alignment (ISA) | NTNU_SB | |||
Traceable Author Statement (TAS) | ProtInc | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Protein-Protein Interactions (88)
1 – 10 of 88
SATB2
Family: TF
Novelty: 0.00405935
p_int: 0.999999989
p_ni: 1.1e-8
p_wrong: 1e-9
Data Source: BioPlex
TRIM47
Novelty: 0.01631355
p_int: 0.999999975
p_ni: 2e-9
p_wrong: 2.3e-8
Data Source: BioPlex
P4HA3
Family: Enzyme
Novelty: 0.03832564
p_int: 0.999996194
p_ni: 0.000003802
p_wrong: 4e-9
Data Source: BioPlex
QPRT
Family: Enzyme
Novelty: 0.00781554
p_int: 0.999986087
p_ni: 0.000009813
p_wrong: 0.0000041
Score: 0.212
Data Source: BioPlex,STRINGDB
SCYL1
Family: Kinase
Novelty: 0.03774351
p_int: 0.994218458
p_ni: 0.005780281
p_wrong: 0.000001261
Data Source: BioPlex
NEMF
Novelty: 0.05052246
p_int: 0.990832409
p_ni: 0.009167591
p_wrong: 1e-9
Data Source: BioPlex
S100A4
Novelty: 0.00136919
p_int: 0.988887757
p_ni: 0.011111334
p_wrong: 9.1e-7
Score: 0.159
Data Source: BioPlex,STRINGDB
RBM12
Novelty: 0.10430477
p_int: 0.90156331
p_ni: 0.04947976
p_wrong: 0.048956931
Data Source: BioPlex
TLE1
Novelty: 0.00594261
p_int: 0.824943778
p_ni: 0.17505612
p_wrong: 1.02e-7
Data Source: BioPlex
CASP6
Family: Enzyme
Novelty: 0.00234346
Score: 0.957
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score 306.65
PubMed score by year
PubTator Score 194.13
PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
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