Tbio SATB1 DNA-binding protein SATB1

Protein Summary

Description

Crucial silencing factor contributing to the initiation of X inactivation mediated by Xist RNA that occurs during embryogenesis and in lymphoma (By similarity). Binds to DNA at special AT-rich sequences, the consensus SATB1-binding sequence (CSBS), at nuclear matrix- or scaffold-associated regions. Thought to recognize the sugar-phosphate structure of double-stranded DNA. Transcriptional repressor controlling nuclear and viral gene expression in a phosphorylated and acetylated status-dependent manner, by binding to matrix attachment regions (MARs) of DNA and inducing a local chromatin-loop remodeling. Acts as a docking site for several chromatin remodeling enzymes (e.g. PML at the MHC-I locus) and also by recruiting corepressors (HDACs) or coactivators (HATs) directly to promoters and enhancers. Modulates genes that are essential in the maturation of the immune T-cell CD8SP from thymocytes. Required for the switching of fetal globin species, and beta- and gamma-globin genes regulation during erythroid differentiation. Plays a role in chromatin organization and nuclear architecture during apoptosis. Interacts with the unique region (UR) of cytomegalovirus (CMV). Alu-like motifs and SATB1-binding sites provide a unique chromatin context which seems preferentially targeted by the HIV-1 integration machinery. Moreover, HIV-1 Tat may overcome SATB1-mediated repression of IL2 and IL2RA (interleukin) in T-cells by binding to the same domain than HDAC1. Delineates specific epigenetic modifications at target gene loci, directly up-regulating metastasis-associated genes while down-regulating tumor-suppressor genes. Reprograms chromatin organization and the transcription profiles of breast tumors to promote growth and metastasis. This gene encodes a matrix protein which binds nuclear matrix and scaffold-associating DNAs through a unique nuclear architecture. The protein recruits chromatin-remodeling factors in order to regulate chromatin structure and gene expression. [provided by RefSeq, Apr 2016]

Uniprot Accession IDs

• Q01826
• B3KXF1
• C9JTR6
• Q59EQ0

Gene Name

• SATB1

Ensembl ID

• ENST00000338745
• ENSP00000341024
• ENSG00000182568
• ENST00000417717
• ENSP00000399518
• ENST00000454909
• ENSP00000399708

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
PubMedID	0.99
transcription factor perturbation	0.96
gene perturbation	0.92
biological process	0.88
disease perturbation	0.87

Protein Classes

PANTHER Classes

Protein / Transcription Factor / Helix-turn-helix Transcription Factor / Lambda Repressor-like Transcription Factor / Dna-binding Protein Satb1

Protein / Transcription Factor / Helix-turn-helix Transcription Factor / Homeodomain Transcription Factor / Dna-binding Protein Satb1

Protein / Nucleic Acid Binding / Dna-binding Protein Satb1

DTO Classes

Protein / Transcription Factor / Helix-turn-helix Transcription Factor / Lambda Repressor-like Transcription Factor / Dna-binding Protein Satb1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 316.06   (req: < 5)

Gene RIFs: 126   (req: <= 3)

Antibodies: 445   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 316.06   (req: >= 5)

Gene RIFs: 126   (req: > 3)

Antibodies: 445   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Expression Data (0 Tissues)

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No expression data found

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Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (88)

Explore Interacting Targets

1 – 10 of 88

• See Interactions on String-DB

SATB2

Tbio

Family:  TF

Novelty:  0.00405935

p_int:  0.999999989

p_ni:  1.1e-8

p_wrong:  1e-9

Data Source:  BioPlex

TRIM47

Tbio

Novelty:  0.01631355

p_int:  0.999999975

p_ni:  2e-9

p_wrong:  2.3e-8

Data Source:  BioPlex

P4HA3

Tbio

Family:  Enzyme

Novelty:  0.03832564

p_int:  0.999996194

p_ni:  0.000003802

p_wrong:  4e-9

Data Source:  BioPlex

QPRT

Tbio

Family:  Enzyme

Novelty:  0.00781554

p_int:  0.999986087

p_ni:  0.000009813

p_wrong:  0.0000041

Score:  0.212

Data Source:  BioPlex,STRINGDB

SCYL1

Tbio

Family:  Kinase

Novelty:  0.03774351

p_int:  0.994218458

p_ni:  0.005780281

p_wrong:  0.000001261

Data Source:  BioPlex

NEMF

Tbio

Novelty:  0.05052246

p_int:  0.990832409

p_ni:  0.009167591

p_wrong:  1e-9

Data Source:  BioPlex

S100A4

Tchem

Novelty:  0.00136919

p_int:  0.988887757

p_ni:  0.011111334

p_wrong:  9.1e-7

Score:  0.159

Data Source:  BioPlex,STRINGDB

RBM12

Tbio

Novelty:  0.10430477

p_int:  0.90156331

p_ni:  0.04947976

p_wrong:  0.048956931

Data Source:  BioPlex

TLE1

Tbio

Novelty:  0.00594261

p_int:  0.824943778

p_ni:  0.17505612

p_wrong:  1.02e-7

Data Source:  BioPlex

CASP6

Tchem

Family:  Enzyme

Novelty:  0.00234346

Score:  0.957

Data Source:  Reactome,STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (20)

Reactome (9)

PathwayCommons (1)

WikiPathways (10)

Apoptosis (R-HSA-109581)

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1 – 5 of 9

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Apoptosis	177 targets	R-HSA-109581
Reactome	Apoptotic cleavage of cellular proteins	38 targets	R-HSA-111465
Reactome	Apoptotic execution phase	52 targets	R-HSA-75153
Reactome	Metabolism of proteins	2050 targets	R-HSA-392499
Reactome	Post-translational protein modification	1450 targets	R-HSA-597592

Name	Explore in Pharos	Explore in Source
Apoptosis	177 targets	R-HSA-109581
Apoptotic cleavage of cellular proteins	38 targets	R-HSA-111465
Apoptotic execution phase	52 targets	R-HSA-75153
Metabolism of proteins	2050 targets	R-HSA-392499
Post-translational protein modification	1450 targets	R-HSA-597592

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (22)

Functions (6)

Components (6)

Processes (10)

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10

1 – 6 of 6

GO Term	Evidence	Assigned by
DNA-binding transcription repressor activity, RNA polymerase II-specific	Inferred from Direct Assay (IDA)	NTNU_SB
RNA polymerase II regulatory region sequence-specific DNA binding	Inferred from Direct Assay (IDA)	NTNU_SB
sequence-specific DNA binding	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
DNA-binding transcription factor activity, RNA polymerase II-specific	Inferred from Sequence Alignment (ISA)	NTNU_SB
double-stranded DNA binding	Traceable Author Statement (TAS)	ProtInc
chromatin binding	Inferred from Electronic Annotation (IEA)	Ensembl

Disease Associations ()

No disease associations found

GWAS Traits (5)

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5

1 – 5 of 5

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
platelet count	EFO_0004309	3	1	2	2.8	84.9
mean platelet volume	EFO_0004584	2	1	2		79.9
platelet crit	EFO_0007985	1	1	1		56.8
cigarettes per day measurement	EFO_0006525	1	1	1		29
self reported educational attainment	EFO_0004784	1	1	1		24.5

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 5 of 5

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
platelet count	EFO_0004309	2	2.8	84.9
mean platelet volume	EFO_0004584	2		79.9
platelet crit	EFO_0007985	1		56.8
cigarettes per day measurement	EFO_0006525	1		29
self reported educational attainment	EFO_0004784	1		24.5

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UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
Acetylation
Alternative splicing
Chromatin regulator
Chromosomal rearrangement
Complete proteome
DNA-binding
Homeobox
Host-virus interaction
Isopeptide bond

GWAS Trait Find Similar Targets

No Header	No Header
cigarettes per day measurement
mean platelet volume
platelet count
platelet crit
self reported educational attainment

MGI Phenotype Find Similar Targets

No Header	No Header
adipose tissue phenotype
behavior/neurological phenotype
cellular phenotype
endocrine/exocrine gland phenotype
growth/size/body region phenotype
hematopoietic system phenotype
immune system phenotype
mortality/aging
nervous system phenotype
skeleton phenotype

IDG Resources

No IDG generated resources found

Orthologs (11)

1 – 5 of 11

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Macaque	SATB homeobox 1		696862
Mouse	special AT-rich sequence binding protein 1	MGI:105084	20230
Rat	SATB homeobox 1	RGD:1305561	316164
Dog	SATB homeobox 1	VGNC:45875	485650
Horse	SATB homeobox 1	VGNC:22700	100033929

Species	Name	OMA	EggNOG	Inparanoid
Macaque	SATB homeobox 1
Mouse	special AT-rich sequence binding protein 1
Rat	SATB homeobox 1
Dog	SATB homeobox 1
Horse	SATB homeobox 1

Publication Statistics

PubMed Score 316.06

PubMed score by year

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PubTator Score 194.13

PubTator score by year

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Related Publications

Text Mined References (148)

GeneRif Annotations (126)

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10

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PMID	Year	Title