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Tbio
OTUD4
OTU domain-containing protein 4

Protein Summary
Description
Deubiquitinase which hydrolyzes the isopeptide bond between the ubiquitin C-terminus and the lysine epsilon-amino group of the target protein (PubMed:23827681, PubMed:25944111, PubMed:29395066). May negatively regulate inflammatory and pathogen recognition signaling in innate immune response. Upon phosphorylation at Ser-202 and Ser-204 residues, via IL-1 receptor and Toll-like receptor signaling pathway, specifically deubiquitinates 'Lys-63'-polyubiquitinated MYD88 adapter protein triggering down-regulation of NF-kappa-B-dependent transcription of inflammatory mediators (PubMed:29395066). Independently of the catalytic activity, acts as a scaffold for alternative deubiquitinases to assemble specific deubiquitinase-substrate complexes. Associates with USP7 and USP9X deubiquitinases to stabilize alkylation repair enzyme ALKBH3, thereby promoting the repair of alkylated DNA lesions (PubMed:25944111). Alternatively spliced transcript variants have been found for this gene. The smaller prot ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000447906
  • ENSP00000395487
  • ENSG00000164164
  • ENST00000454497
  • ENSP00000409279
  • ENST00000509620
  • ENSP00000424192

Symbol
  • HIN-1
  • KIAA1046
  • HIN1
  • DUBA6
  • HSHIN1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
microRNA
0.88
virus perturbation
0.88
transcription factor perturbation
0.84
ligand (protein) perturbation
0.83
histone modification site profile
0.79


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.72   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 170   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.72   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 170   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
3
2
5
92.3
red blood cell density measurement
1
1
1
70.8
reticulocyte count
3
2
3
67
mean corpuscular volume
1
2
2
60.1
mean reticulocyte volume
1
2
2
58.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
5
92.3
red blood cell density measurement
1
70.8
reticulocyte count
3
67
mean corpuscular volume
2
60.1
mean reticulocyte volume
2
58.9
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
OTU deubiquitinase 4
701837
Mouse
MGI:1098801
73945
Rat
RGD:1305606
307774
Dog
OTU deubiquitinase 4
VGNC:44186
475455
Horse
OTU deubiquitinase 4
VGNC:21089
100070999
Species
Name
OMA
EggNOG
Inparanoid
Macaque
OTU deubiquitinase 4
Mouse
Rat
Dog
OTU deubiquitinase 4
Horse
OTU deubiquitinase 4
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q01804-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Protein-Protein Interactions (99)
1 – 10 of 99
MYCBP
Tbio
Novelty: 0.03202836
p_int: 0.999999965
p_ni: 3.5e-8
Data Source: BioPlex
TRAF1
Tbio
Novelty: 0.00526776
p_int: 0.999999098
p_ni: 9.02e-7
Score: 0.217
Data Source: BioPlex,STRINGDB
CRY2
Tbio
Novelty: 0.00156961
p_int: 0.999997964
p_ni: 0.000002036
Data Source: BioPlex
VTN
Tbio
Family: TF
Novelty: 0.00046861
p_int: 0.999994755
p_ni: 0.000005234
p_wrong: 1.2e-8
Data Source: BioPlex
HTRA4
Tbio
Family: Enzyme
Novelty: 0.09298487
p_int: 0.999993927
p_ni: 0.000006073
Score: 0.198
Data Source: BioPlex,STRINGDB
WBP2NL
Tbio
Novelty: 0.03957932
p_int: 0.998784943
p_ni: 0.001215053
p_wrong: 4e-9
Score: 0.308
Data Source: BioPlex,STRINGDB
DAZ2
Tbio
p_int: 0.998116386
p_ni: 0.001883612
p_wrong: 2e-9
Data Source: BioPlex
ODAPH
Tbio
Novelty: 0.20386223
p_int: 0.992364354
p_ni: 0.007392478
p_wrong: 0.000243168
Data Source: BioPlex
IQCN
Tdark
Novelty: 2.74045479
p_int: 0.985369627
p_ni: 0.013404646
p_wrong: 0.001225727
Data Source: BioPlex
ZBTB49
Tdark
Family: TF
Novelty: 2.32287223
p_int: 0.971821702
p_ni: 0.028178235
p_wrong: 6.3e-8
Data Source: BioPlex
Publication Statistics
PubMed Score  8.72

PubMed score by year
PubTator Score  65.66

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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