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Tbio
EXOSC10
Exosome component 10

Protein Summary
Description
Putative catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pat ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000304457
  • ENSP00000307307
  • ENSG00000171824
  • ENST00000376936
  • ENSP00000366135

Symbol
  • PMSCL
  • PMSCL2
  • RRP6
  • p2
  • p3
  • p4
  • RRP6
  • PMSCL
  • Rrp6p
  • PM-Scl
  • PMSCL2
  • PM/Scl-100
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
1
hub protein
0.9
histone modification site profile
0.83
protein domain
0.73
kinase perturbation
0.71


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 315.34   (req: < 5)
Gene RIFs: 15   (req: <= 3)
Antibodies: 167   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 315.34   (req: >= 5)
Gene RIFs: 15   (req: > 3)
Antibodies: 167   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (18)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
Alopecia
1
4
4
97.2
balding measurement
2
2
2
95.8
3
3
1
1.3
95.7
corneal topography
4
2
4
92.6
heel bone mineral density
3
3
4
89.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
Alopecia
4
97.2
balding measurement
2
95.8
1
1.3
95.7
corneal topography
4
92.6
heel bone mineral density
4
89.3
Orthologs (16)
1 – 5 of 16
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
exosome component 10
VGNC:538
457944
Macaque
exosome component 10
714153
Mouse
MGI:1355322
50912
Rat
RGD:1593248
313707
Dog
exosome component 10
VGNC:40522
478233
Species
Name
OMA
EggNOG
Inparanoid
Chimp
exosome component 10
Macaque
exosome component 10
Mouse
Rat
Dog
exosome component 10
Protein Structure (6 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q01780-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 6
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (5)
Major pathway of rRNA processing in the nucleolus and cytosol (R-HSA-6791226)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Major pathway of rRNA processing in the nucleolus and cytosol
Reactome
Metabolism of RNA
Reactome
rRNA processing
Reactome
rRNA processing in the nucleus and cytosol
Name
Explore in Pharos
Explore in Source
Major pathway of rRNA processing in the nucleolus and cytosol
Metabolism of RNA
rRNA processing
rRNA processing in the nucleus and cytosol
Gene Ontology Terms (26)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Mutant Phenotype (IMP)
BHF-UCL
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred by Curator (IC)
BHF-UCL
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (400)
1 – 10 of 400
C1D
Tbio
Novelty:  0.00997109
p_int:  0.999997815
p_ni:  0.000002185
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
EXOSC3
Tbio
Novelty:  0.03072164
p_int:  0.99999136
p_ni:  0.00000864
Score:  0.999
Data Source:  BioPlex,STRINGDB
EXOSC7
Tbio
Family:  Enzyme
Novelty:  0.07422851
p_int:  0.999988508
p_ni:  0.000011492
Score:  0.999
Data Source:  BioPlex,STRINGDB
EXOSC8
Tbio
Family:  Enzyme
Novelty:  0.02013403
p_int:  0.999882937
p_ni:  0.000117063
Score:  0.999
Data Source:  BioPlex,STRINGDB
MPHOSPH6
Tbio
Family:  Enzyme
Novelty:  0.24387167
p_int:  0.999872872
p_ni:  0.000127128
Score:  0.995
Data Source:  BioPlex,Reactome,STRINGDB
EXOSC1
Tbio
Novelty:  0.01386842
p_int:  0.999826612
p_ni:  0.000173388
Score:  0.999
Data Source:  BioPlex,STRINGDB
ZC3H18
Tdark
Novelty:  0.3515546
p_int:  0.972850552
p_ni:  0.027149448
Score:  0.379
Data Source:  BioPlex,STRINGDB
RPL18A
Tbio
Novelty:  0.04612948
p_int:  0.854498212
p_ni:  0.145501788
Score:  0.95
Data Source:  BioPlex,STRINGDB
DIS3
Tbio
Family:  Enzyme
Novelty:  0.00961238
Score:  0.999
Data Source:  STRINGDB
MTREX
Tbio
Novelty:  0.01358024
Score:  0.999
Data Source:  Reactome,STRINGDB
Publication Statistics
PubMed Score  315.34

PubMed score by year
PubTator Score  593.57

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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