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Tclin
MC1R
Melanocyte-stimulating hormone receptor

Protein Summary
Description
Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. This intronless gene encodes the receptor protein for melanocyte-stimulating hormone (MSH). The encoded protein, a seven pass transmembrane G protein coupled receptor, controls melanogenesis. Two types of melanin exist: red pheomelanin and black eumelanin. Gene mutations that lead to a loss in function are associated with increased pheomelanin production, which leads to lighter skin and hair color. Eumelanin is photoprotective but pheomelanin may contribute to UV-induced skin damage by generating free radicals upon UV radiation. Binding of MSH to its receptor activates the receptor and stimulates eumelanin synthesis. This receptor is a major determining factor in sun sensitivity and is a genetic risk factor for melanoma and non-melanoma skin cancer. Over 30 variant alleles have been identified which correlate with skin and hair color, providing ev ...more
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.91
trait
0.86
gene perturbation
0.78
transcription factor binding site profile
0.75
phenotype
0.73


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 810.76   (req: < 5)
Gene RIFs: 252   (req: <= 3)
Antibodies: 316   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 810.76   (req: >= 5)
Gene RIFs: 252   (req: > 3)
Antibodies: 316   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 19
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 128
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Approved Drugs (1)
1 – 1 of 1
afamelanotide
chemical structure image
Pathways (11)
Class A/1 (Rhodopsin-like receptors) (R-HSA-373076)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
G alpha (s) signalling events
Reactome
GPCR downstream signalling
Reactome
GPCR ligand binding
Reactome
Peptide ligand-binding receptors
Name
Explore in Pharos
Explore in Source
Class A/1 (Rhodopsin-like receptors)
G alpha (s) signalling events
GPCR downstream signalling
GPCR ligand binding
Peptide ligand-binding receptors
Protein-Protein Interactions (205)
1 – 10 of 205
POMC
Tbio
Novelty: 0.00002654
Score: 0.993
Data Source: Reactome,STRINGDB
ASIP
Tbio
Novelty: 0.01705144
Score: 0.988
Data Source: STRINGDB
NPS
Tbio
Novelty: 0.00011983
Score: 0.969
Data Source: STRINGDB
CRH
Tbio
Novelty: 0.00017805
Score: 0.945
Data Source: STRINGDB
MC4R
Tclin
Family: GPCR
Novelty: 0.00104053
Score: 0.938
Data Source: STRINGDB
CRHR1
Tclin
Family: GPCR
Novelty: 0.00121307
Score: 0.932
Data Source: STRINGDB
FSHR
Tclin
Family: GPCR
Novelty: 0.00142021
Score: 0.927
Data Source: STRINGDB
GCG
Tchem
Novelty: 0.00005614
Score: 0.926
Data Source: STRINGDB
GNG13
Tbio
Novelty: 0.14784205
Score: 0.925
Data Source: STRINGDB
CRHR2
Tbio
Family: GPCR
Novelty: 0.00324955
Score: 0.925
Data Source: STRINGDB
Publication Statistics
PubMed Score  810.76

PubMed score by year
PubTator Score  593.67

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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