Tclin MC1R Melanocyte-stimulating hormone receptor

Protein Summary

Description

Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. This intronless gene encodes the receptor protein for melanocyte-stimulating hormone (MSH). The encoded protein, a seven pass transmembrane G protein coupled receptor, controls melanogenesis. Two types of melanin exist: red pheomelanin and black eumelanin. Gene mutations that lead to a loss in function are associated with increased pheomelanin production, which leads to lighter skin and hair color. Eumelanin is photoprotective but pheomelanin may contribute to UV-induced skin damage by generating free radicals upon UV radiation. Binding of MSH to its receptor activates the receptor and stimulates eumelanin synthesis. This receptor is a major determining factor in sun sensitivity and is a genetic risk factor for melanoma and non-melanoma skin cancer. Over 30 variant alleles have been identified which correlate with skin and hair color, providing evidence that this gene is an important component in determining normal human pigment variation. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q01726
• Q66K38
• Q6UR93
• Q8WWX6
• Q8WWX7
• Q96I33
• Q96RU4
• Q9UBF7
• Q9UN58
• Q9UN59
• Q9UN60
• Q9UN61
• Q9UN62
• MSH-R

Gene Name

• MC1R

Ensembl ID

• ENST00000555147
• ENSP00000451605
• ENSG00000258839
• ENST00000639847
• ENSP00000492011

Symbol

• MSHR
• CMM5
• MSH-R
• SHEP2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0.91
trait	0.86
gene perturbation	0.78
transcription factor binding site profile	0.75
phenotype	0.73

Protein Classes

PANTHER Classes

Protein / Receptor / G-protein Coupled Receptor / Melanocyte-stimulating Hormone Receptor

DTO Classes

Protein / G-protein Coupled Receptor / Class A Rhodopsin Like / Melanocortin Receptor / Melanocyte-stimulating Hormone Receptor

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1109.98   (req: < 5)

Gene RIFs: 291   (req: <= 3)

Antibodies: 316   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1109.98   (req: >= 5)

Gene RIFs: 291   (req: > 3)

Antibodies: 316   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 19

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 229

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1