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Tclin
MC1R
Melanocyte-stimulating hormone receptor

Protein Summary
Description
Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. This intronless gene encodes the receptor protein for melanocyte-stimulating hormone (MSH). The encoded protein, a seven pass transmembrane G protein coupled receptor, controls melanogenesis. Two types of melanin exist: red pheomelanin and black eumelanin. Gene mutations that lead to a loss in function are associated with increased pheomelanin production, which leads to lighter skin and hair color. Eumelanin is photoprotective but pheomelanin may contribute to UV-induced skin damage by generating free radicals upon UV radiation. Binding of MSH to its receptor activates the receptor and stimulates eumelanin synthesis. This receptor is a major determining factor in sun sensitivity and is a genetic risk factor for melanoma and non-melanoma skin cancer. Over 30 variant alleles have been identified which correlate with skin and hair color, providing ev ...more
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.91
trait
0.86
gene perturbation
0.78
transcription factor binding site profile
0.75
phenotype
0.73


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1109.98   (req: < 5)
Gene RIFs: 252   (req: <= 3)
Antibodies: 316   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1109.98   (req: >= 5)
Gene RIFs: 252   (req: > 3)
Antibodies: 316   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 19
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 229
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
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ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Active Ligands (229)
CHEMBL2070245
Rendered image for CHEMBL2070245
CHEMBL2070251
Rendered image for CHEMBL2070251
CHEMBL2070243
Rendered image for CHEMBL2070243
CHEMBL4093140
Rendered image for CHEMBL4093140
CHEMBL3601428
Rendered image for CHEMBL3601428
CHEMBL3600918
Rendered image for CHEMBL3600918
CHEMBL4212762
Rendered image for CHEMBL4212762
Protein-Protein Interactions (205)
POMC
Tbio
Novelty:  0.00002436
Score:  0.993
Data Source:  Reactome,STRINGDB
ASIP
Tbio
Novelty:  0.0139136
Score:  0.988
Data Source:  STRINGDB
NPS
Tbio
Novelty:  0.00692108
Score:  0.969
Data Source:  STRINGDB
CRH
Tbio
Novelty:  0.000147
Score:  0.945
Data Source:  STRINGDB
MC4R
Tclin
Family:  GPCR
Novelty:  0.00091593
Score:  0.938
Data Source:  STRINGDB
CRHR1
Tclin
Family:  GPCR
Novelty:  0.00101773
Score:  0.932
Data Source:  STRINGDB
FSHR
Tclin
Family:  GPCR
Novelty:  0.00123929
Score:  0.927
Data Source:  STRINGDB
GCG
Tchem
Novelty:  0.00004879
Score:  0.926
Data Source:  STRINGDB
GNG13
Tbio
Novelty:  0.13011919
Score:  0.925
Data Source:  STRINGDB
CRHR2
Tchem
Family:  GPCR
Novelty:  0.00245379
Score:  0.925
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (11)
Class A/1 (Rhodopsin-like receptors) (R-HSA-373076)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
G alpha (s) signalling events
Reactome
GPCR downstream signalling
Reactome
GPCR ligand binding
Reactome
Peptide ligand-binding receptors
Name
Explore in Pharos
Explore in Source
Class A/1 (Rhodopsin-like receptors)
G alpha (s) signalling events
GPCR downstream signalling
GPCR ligand binding
Peptide ligand-binding receptors
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (21)
Find Similar Targets
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
UniProtKB
Traceable Author Statement (TAS)
BHF-UCL
Traceable Author Statement (TAS)
ProtInc
Disease Associations (null)
No disease associations found
GWAS Traits (36)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hair color
10
32
1
2.4
100
suntan
3
9
9
99.8
hair colour measurement
2
7
7
99.2
4
3
2
1.4
99.2
2
5
0
1.4
99.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hair color
1
2.4
100
suntan
9
99.8
hair colour measurement
7
99.2
2
1.4
99.2
0
1.4
99.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (5)
1 – 5 of 5
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:99456
17199
Horse
melanocortin 1 receptor
100136907
Cow
melanocortin 1 receptor
281298
Pig
melanocortin 1 receptor
494018
Zebrafish
ZDB-GENE-030502-1
353151
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Horse
melanocortin 1 receptor
Cow
melanocortin 1 receptor
Pig
melanocortin 1 receptor
Zebrafish
Publication Statistics
PubMed Score 1109.98
PubMed score by year
PubTator Score 593.67
PubTator score by year
Patents
Patents by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title