Tclin MC2R Adrenocorticotropic hormone receptor

Protein Summary

Description

Receptor for corticotropin (ACTH). This receptor is mediated by G proteins (G(s)) which activate adenylate cyclase (cAMP). MC2R encodes one member of the five-member G-protein associated melanocortin receptor family. Melanocortins (melanocyte-stimulating hormones and adrenocorticotropic hormone) are peptides derived from pro-opiomelanocortin (POMC). MC2R is selectively activated by adrenocorticotropic hormone, whereas the other four melanocortin receptors recognize a variety of melanocortin ligands. Mutations in MC2R can result in familial glucocorticoid deficiency. Alternate transcript variants have been found for this gene. [provided by RefSeq, May 2014]

Uniprot Accession IDs

• Q01718
• A8K016
• Q3MI45
• Q504X6
• ACTH receptor

Gene Name

• MC2R

Ensembl ID

• ENST00000327606
• ENSP00000333821
• ENSG00000185231

Symbol

• ACTHR
• ACTHR

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
co-expressed gene	0.99
cell type or tissue	0.72
gene perturbation	0.68
microRNA	0.62
protein domain	0.58

Protein Classes

PANTHER Classes

Protein / Receptor / G-protein Coupled Receptor / Adrenocorticotropic Hormone Receptor

DTO Classes

Protein / G-protein Coupled Receptor / Class A Rhodopsin Like / Melanocortin Receptor / Adrenocorticotropic Hormone Receptor

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 248.14   (req: < 5)

Gene RIFs: 63   (req: <= 3)

Antibodies: 262   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 248.14   (req: >= 5)

Gene RIFs: 63   (req: > 3)

Antibodies: 262   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 3