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Tclin
MC2R
Adrenocorticotropic hormone receptor

Protein Summary
Description
Receptor for corticotropin (ACTH). This receptor is mediated by G proteins (G(s)) which activate adenylate cyclase (cAMP). MC2R encodes one member of the five-member G-protein associated melanocortin receptor family. Melanocortins (melanocyte-stimulating hormones and adrenocorticotropic hormone) are peptides derived from pro-opiomelanocortin (POMC). MC2R is selectively activated by adrenocorticotropic hormone, whereas the other four melanocortin receptors recognize a variety of melanocortin ligands. Mutations in MC2R can result in familial glucocorticoid deficiency. Alternate transcript variants have been found for this gene. [provided by RefSeq, May 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000327606
  • ENSP00000333821
  • ENSG00000185231

Symbol
  • ACTHR
  • ACTHR
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
0.99
cell type or tissue
0.72
gene perturbation
0.68
microRNA
0.62
protein domain
0.58


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 205.97   (req: < 5)
Gene RIFs: 55   (req: <= 3)
Antibodies: 262   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 205.97   (req: >= 5)
Gene RIFs: 55   (req: > 3)
Antibodies: 262   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 3
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
parental longevity
1
1
1
29.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
parental longevity
1
29.7
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
melanocortin 2 receptor
701312
Mouse
MGI:96928
17200
Rat
RGD:628649
282839
Dog
melanocortin 2 receptor
VGNC:43066
100855756
Horse
melanocortin 2 receptor
VGNC:20020
100057018
Species
Name
OMA
EggNOG
Inparanoid
Macaque
melanocortin 2 receptor
Mouse
Rat
Dog
melanocortin 2 receptor
Horse
melanocortin 2 receptor
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q01718-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (18)
Class A/1 (Rhodopsin-like receptors) (R-HSA-373076)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 11
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD)
Reactome
Disease
Reactome
Diseases of metabolism
Reactome
G alpha (s) signalling events
Name
Explore in Pharos
Explore in Source
Class A/1 (Rhodopsin-like receptors)
Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD)
Disease
Diseases of metabolism
G alpha (s) signalling events
Protein-Protein Interactions (181)
1 – 10 of 181
POMC
Tbio
Novelty: 0.00002436
Score: 0.997
Data Source: Reactome,STRINGDB
MRAP
Tbio
Novelty: 0.00628223
Score: 0.992
Data Source: STRINGDB
CRH
Tbio
Novelty: 0.000147
Score: 0.978
Data Source: STRINGDB
NPS
Tbio
Novelty: 0.00692108
Score: 0.971
Data Source: STRINGDB
CRHR1
Tclin
Family: GPCR
Novelty: 0.00101773
Score: 0.958
Data Source: STRINGDB
CRHR2
Tbio
Family: GPCR
Novelty: 0.00245379
Score: 0.946
Data Source: STRINGDB
GIPR
Tchem
Family: GPCR
Novelty: 0.00961809
Score: 0.942
Data Source: STRINGDB
GNAS
Tbio
Novelty: 0.00284739
Score: 0.934
Data Source: STRINGDB
GNAS
Tbio
Novelty: 0.00284739
Score: 0.934
Data Source: STRINGDB
GNAS
Tbio
Novelty: 0.00284739
Score: 0.934
Data Source: STRINGDB
Publication Statistics
PubMed Score  205.97

PubMed score by year
PubTator Score  247.82

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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