Tclin CACNA1D Voltage-dependent L-type calcium channel subunit alpha-1D

Protein Summary

Description

Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1D gives rise to L-type calcium currents. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group. They are blocked by dihydropyridines (DHP), phenylalkylamines, and by benzothiazepines. Voltage-dependent calcium channels mediate the entry of calcium ions into excitable cells, and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, and gene expression. Calcium channels are multisubunit complexes composed of alpha-1, beta, alpha-2/delta, and gamma subunits. The channel activity is directed by the pore-forming alpha-1 subunit, whereas the others act as auxiliary subunits regulating this activity. The distinctive properties of the calcium channel types are related primarily to the expression of a variety of alpha-1 isoforms, namely alpha-1A, B, C, D, E, and S. This gene encodes the alpha-1D subunit. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2012]

Uniprot Accession IDs

• Q01668
• B0FYA3
• Q13916
• Q13931
• Q71UT1
• Q9UDC3

Gene Name

• CACNA1D

Ensembl ID

• ENST00000288139
• ENSP00000288139
• ENSG00000157388
• ENST00000350061
• ENSP00000288133
• ENST00000422281
• ENSP00000409174
• ENST00000645528
• ENSP00000494413

Symbol

• CACH3
• CACN4
• CACNL1A2
• CCHL1A2
• CACH3
• CACN4
• PASNA
• SANDD
• Cav1.3
• CCHL1A2
• CACNL1A2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.96
trait	0.93
protein domain	0.85
transcription factor	0.83
drug	0.72

Protein Classes

DTO Classes

Protein / Ion Channel / Calcium Channel Alpha-1 Subunit Family / Cacna1d Subfamily / Voltage-dependent L-type Calcium Channel Subunit Alpha-1d

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 406.42   (req: < 5)

Gene RIFs: 74   (req: <= 3)

Antibodies: 285   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 406.42   (req: >= 5)

Gene RIFs: 74   (req: > 3)

Antibodies: 285   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 24

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 8

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 24