Tbio DR1 Protein Dr1

Protein Summary

Description

The association of the DR1/DRAP1 heterodimer with TBP results in a functional repression of both activated and basal transcription of class II genes. This interaction precludes the formation of a transcription-competent complex by inhibiting the association of TFIIA and/or TFIIB with TBP. Can bind to DNA on its own. Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4. This gene encodes a TBP- (TATA box-binding protein) associated phosphoprotein that represses both basal and activated levels of transcription. The encoded protein is phosphorylated in vivo and this phosphorylation affects its interaction with TBP. This protein contains a histone fold motif at the amino terminus, a TBP-binding domain, and a glutamine- and alanine-rich region. The binding of DR1 repressor complexes to TBP-promoter complexes may establish a mechanism in which an altered DNA conformation, together with the formation of higher order complexes, inhibits the assembly of the preinitiation complex and controls the rate of RNA polymerase II transcription. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q01658

Gene Name

• DR1

Ensembl ID

• ENST00000370267
• ENSP00000359290
• ENSG00000117505
• ENST00000370272
• ENSP00000359295

Symbol

• NC2
• NC2B
• NCB2
• NC2-BETA

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	0.95
virus perturbation	0.85
transcription factor binding site profile	0.79
kinase perturbation	0.71
tissue sample	0.71

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 710.7   (req: < 5)

Gene RIFs: 11   (req: <= 3)

Antibodies: 186   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 710.7   (req: >= 5)

Gene RIFs: 11   (req: > 3)

Antibodies: 186   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Expression Data (0 Tissues)

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No expression data found

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Target Illumination GWAS Analytics (TIGA)

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (95)

Explore Interacting Targets

1 – 10 of 95

• See Interactions on String-DB

TADA2A

Tbio

Family:  TF

Novelty:  0.07665459

p_int:  0.99999999

p_ni:  1e-8

Score:  0.961

Data Source:  BioPlex,STRINGDB

KAT14

Tbio

Novelty:  0.17168043

p_int:  0.999999978

p_ni:  2.2e-8

Score:  0.953

Data Source:  BioPlex,STRINGDB

KAT2B

Tchem

Family:  Epigenetic

Novelty:  0.00172126

p_int:  0.999999945

p_ni:  5.5e-8

Score:  0.956

Data Source:  BioPlex,STRINGDB

DRAP1

Tbio

Novelty:  0.05872031

p_int:  0.999999906

p_ni:  9.4e-8

Score:  0.997

Data Source:  BioPlex,STRINGDB

ZZZ3

Tdark

Family:  TF

Novelty:  0.23862921

p_int:  0.999999661

p_ni:  3.39e-7

Score:  0.908

Data Source:  BioPlex,STRINGDB

YEATS2

Tbio

Novelty:  0.17584498

p_int:  0.999999569

p_ni:  4.31e-7

Score:  0.975

Data Source:  BioPlex,STRINGDB

KAT2A

Tchem

Family:  Epigenetic

Novelty:  0.00238831

p_int:  0.99999942

p_ni:  5.8e-7

Score:  0.958

Data Source:  BioPlex,STRINGDB

SGF29

Tbio

Family:  Epigenetic

Novelty:  0.0426456

p_int:  0.999982644

p_ni:  0.000017356

Score:  0.971

Data Source:  BioPlex,STRINGDB

MIER1

Tbio

Novelty:  0.00357772

p_int:  0.999595359

p_ni:  0.000404628

p_wrong:  1.3e-8

Score:  0.212

Data Source:  BioPlex,STRINGDB

MBIP

Tbio

Novelty:  0.05807454

p_int:  0.995217426

p_ni:  0.004782574

Score:  0.992

Data Source:  BioPlex,STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (3)

Reactome (3)

Chromatin modifying enzymes (R-HSA-3247509)

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1 – 3 of 3

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Chromatin modifying enzymes	238 targets	R-HSA-3247509
Reactome	Chromatin organization	238 targets	R-HSA-4839726
Reactome	HATs acetylate histones	107 targets	R-HSA-3214847

Name	Explore in Pharos	Explore in Source
Chromatin modifying enzymes	238 targets	R-HSA-3247509
Chromatin organization	238 targets	R-HSA-4839726
HATs acetylate histones	107 targets	R-HSA-3214847

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (16)

Functions (7)

Components (3)

Processes (6)

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1 – 7 of 7

GO Term	Evidence	Assigned by
TBP-class protein binding	Inferred from Direct Assay (IDA)	BHF-UCL
core promoter binding	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
transcription corepressor activity	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
DNA-binding transcription factor activity, RNA polymerase II-specific	Inferred from Sequence Model (ISM)	NTNU_SB
DNA binding	Traceable Author Statement (TAS)	ProtInc
transcription factor binding	Traceable Author Statement (TAS)	ProtInc
protein heterodimerization activity	Inferred from Electronic Annotation (IEA)	InterPro

Disease Associations ()

No disease associations found

GWAS Traits (20)

• Explore on Target Illumination GWAS Analytics (TIGA)

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1 – 5 of 20

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
high density lipoprotein cholesterol measurement	EFO_0004612	5	4	7		93.2
eosinophil count	EFO_0004842	2	1	2		79
self reported educational attainment	EFO_0004784	1	1	1		70.5
alkaline phosphatase measurement	EFO_0004533	2	1	1	7	64.4
triglyceride measurement	EFO_0004530	2	2	2		57.7

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 5 of 20

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
high density lipoprotein cholesterol measurement	EFO_0004612	7		93.2
eosinophil count	EFO_0004842	2		79
self reported educational attainment	EFO_0004784	1		70.5
alkaline phosphatase measurement	EFO_0004533	1	7	64.4
triglyceride measurement	EFO_0004530	2		57.7

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UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
Acetylation
Complete proteome
Direct protein sequencing
DNA-binding
Nucleus
Phosphoprotein
Polymorphism
Reference proteome
Repressor

GWAS Trait Find Similar Targets

No Header	No Header
alkaline phosphatase measurement
apolipoprotein A 1 measurement
C-reactive protein measurement
eosinophil count
eosinophil percentage of granulocytes
eosinophil percentage of leukocytes
glucose measurement
high density lipoprotein cholesterol measurement
mathematical ability
mean corpuscular hemoglobin concentration

IDG Resources

No IDG generated resources found

Orthologs (15)

1 – 5 of 15

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	down-regulator of transcription 1	VGNC:11312	457031
Mouse	down-regulator of transcription 1	MGI:1100515	13486
Rat	down-regulator of transcription 1	RGD:1305201	289881
Dog	down-regulator of transcription 1	VGNC:40087	479943
Horse	down-regulator of transcription 1	VGNC:17308	100059248

Species	Name	OMA	EggNOG	Inparanoid
Chimp	down-regulator of transcription 1
Mouse	down-regulator of transcription 1
Rat	down-regulator of transcription 1
Dog	down-regulator of transcription 1
Horse	down-regulator of transcription 1

Publication Statistics

PubMed Score 710.70

PubMed score by year

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PubTator Score 650.07

PubTator score by year

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Related Publications

Text Mined References (30)

GeneRif Annotations (11)

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PMID	Year	Title