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Tbio
DR1
Protein Dr1

Protein Summary
Description
The association of the DR1/DRAP1 heterodimer with TBP results in a functional repression of both activated and basal transcription of class II genes. This interaction precludes the formation of a transcription-competent complex by inhibiting the association of TFIIA and/or TFIIB with TBP. Can bind to DNA on its own. Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4. This gene encodes a TBP- (TATA box-binding protein) associated phosphoprotein that represses both basal and activated levels of transcription. The encoded protein is phosphorylated in vivo and this phosphorylation affects its interaction with TBP. This protein contains a histone fold motif at the amino terminus, a TBP-binding domain, and a glutamine- and alanine-rich region. The binding of DR1 repressor complexes to TBP-promoter complexes may establish a mechanism in which an altered DNA conformation, together with the formation of higher order complexes, inhibits the ass ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000370267
  • ENSP00000359290
  • ENSG00000117505
  • ENST00000370272
  • ENSP00000359295

Symbol
  • NC2
  • NC2B
  • NCB2
  • NC2-BETA
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.95
virus perturbation
0.85
transcription factor binding site profile
0.79
kinase perturbation
0.71
tissue sample
0.71


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 710.7   (req: < 5)
Gene RIFs: 11   (req: <= 3)
Antibodies: 186   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 710.7   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 186   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (95)
TADA2A
Tbio
Family:  TF
Novelty:  0.07665459
p_int:  0.99999999
p_ni:  1e-8
Score:  0.961
Data Source:  BioPlex,STRINGDB
KAT14
Tbio
Novelty:  0.17168043
p_int:  0.999999978
p_ni:  2.2e-8
Score:  0.953
Data Source:  BioPlex,STRINGDB
KAT2B
Tchem
Family:  Epigenetic
Novelty:  0.00172126
p_int:  0.999999945
p_ni:  5.5e-8
Score:  0.956
Data Source:  BioPlex,STRINGDB
DRAP1
Tbio
Novelty:  0.05872031
p_int:  0.999999906
p_ni:  9.4e-8
Score:  0.997
Data Source:  BioPlex,STRINGDB
ZZZ3
Tdark
Family:  TF
Novelty:  0.23862921
p_int:  0.999999661
p_ni:  3.39e-7
Score:  0.908
Data Source:  BioPlex,STRINGDB
YEATS2
Tbio
Novelty:  0.17584498
p_int:  0.999999569
p_ni:  4.31e-7
Score:  0.975
Data Source:  BioPlex,STRINGDB
KAT2A
Tchem
Family:  Epigenetic
Novelty:  0.00238831
p_int:  0.99999942
p_ni:  5.8e-7
Score:  0.958
Data Source:  BioPlex,STRINGDB
SGF29
Tbio
Family:  Epigenetic
Novelty:  0.0426456
p_int:  0.999982644
p_ni:  0.000017356
Score:  0.971
Data Source:  BioPlex,STRINGDB
MIER1
Tbio
Novelty:  0.00357772
p_int:  0.999595359
p_ni:  0.000404628
p_wrong:  1.3e-8
Score:  0.212
Data Source:  BioPlex,STRINGDB
MBIP
Tbio
Novelty:  0.05807454
p_int:  0.995217426
p_ni:  0.004782574
Score:  0.992
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (3)
Chromatin modifying enzymes (R-HSA-3247509)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Chromatin modifying enzymes
Reactome
Chromatin organization
Reactome
HATs acetylate histones
Name
Explore in Pharos
Explore in Source
Chromatin modifying enzymes
Chromatin organization
HATs acetylate histones
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (16)
Find Similar Targets
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence Model (ISM)
NTNU_SB
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations ()
No disease associations found
GWAS Traits (20)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
5
4
7
93.2
eosinophil count
2
1
2
79
self reported educational attainment
1
1
1
70.5
alkaline phosphatase measurement
2
1
1
7
64.4
triglyceride measurement
2
2
2
57.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
7
93.2
eosinophil count
2
79
self reported educational attainment
1
70.5
alkaline phosphatase measurement
1
7
64.4
triglyceride measurement
2
57.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
down-regulator of transcription 1
VGNC:11312
457031
Mouse
MGI:1100515
13486
Rat
RGD:1305201
289881
Dog
down-regulator of transcription 1
VGNC:40087
479943
Horse
down-regulator of transcription 1
VGNC:17308
100059248
Species
Name
OMA
EggNOG
Inparanoid
Chimp
down-regulator of transcription 1
Mouse
Rat
Dog
down-regulator of transcription 1
Horse
down-regulator of transcription 1
Publication Statistics
PubMed Score 710.70
PubMed score by year
PubTator Score 650.07
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title