Protein Summary
The association of the DR1/DRAP1 heterodimer with TBP results in a functional repression of both activated and basal transcription of class II genes. This interaction precludes the formation of a transcription-competent complex by inhibiting the association of TFIIA and/or TFIIB with TBP. Can bind to DNA on its own. Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4. This gene encodes a TBP- (TATA box-binding protein) associated phosphoprotein that represses both basal and activated levels of transcription. The encoded protein is phosphorylated in vivo and this phosphorylation affects its interaction with TBP. This protein contains a histone fold motif at the amino terminus, a TBP-binding domain, and a glutamine- and alanine-rich region. The binding of DR1 repressor complexes to TBP-promoter complexes may establish a mechanism in which an altered DNA conformation, together with the formation of higher order complexes, inhibits the ass ...more
- ENST00000370267
- ENSP00000359290
- ENSG00000117505
- ENST00000370272
- ENSP00000359295
- NC2
- NC2B
- NCB2
- NC2-BETA
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
disease perturbation | 0.95 | ||
virus perturbation | 0.85 | ||
transcription factor binding site profile | 0.79 | ||
kinase perturbation | 0.71 | ||
tissue sample | 0.71 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 710.7 (req: < 5)
Gene RIFs: 11 (req: <= 3)
Antibodies: 186 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 710.7 (req: >= 5)
Gene RIFs: 11 (req: > 3)
Antibodies: 186 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 13
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (95)
TADA2A
Family: TF
Novelty: 0.07665459
p_int: 0.99999999
p_ni: 1e-8
Score: 0.961
Data Source: BioPlex,STRINGDB
KAT14
Novelty: 0.17168043
p_int: 0.999999978
p_ni: 2.2e-8
Score: 0.953
Data Source: BioPlex,STRINGDB
KAT2B
Family: Epigenetic
Novelty: 0.00172126
p_int: 0.999999945
p_ni: 5.5e-8
Score: 0.956
Data Source: BioPlex,STRINGDB
DRAP1
Novelty: 0.05872031
p_int: 0.999999906
p_ni: 9.4e-8
Score: 0.997
Data Source: BioPlex,STRINGDB
ZZZ3
Family: TF
Novelty: 0.23862921
p_int: 0.999999661
p_ni: 3.39e-7
Score: 0.908
Data Source: BioPlex,STRINGDB
YEATS2
Novelty: 0.17584498
p_int: 0.999999569
p_ni: 4.31e-7
Score: 0.975
Data Source: BioPlex,STRINGDB
KAT2A
Family: Epigenetic
Novelty: 0.00238831
p_int: 0.99999942
p_ni: 5.8e-7
Score: 0.958
Data Source: BioPlex,STRINGDB
SGF29
Family: Epigenetic
Novelty: 0.0426456
p_int: 0.999982644
p_ni: 0.000017356
Score: 0.971
Data Source: BioPlex,STRINGDB
MIER1
Novelty: 0.00357772
p_int: 0.999595359
p_ni: 0.000404628
p_wrong: 1.3e-8
Score: 0.212
Data Source: BioPlex,STRINGDB
MBIP
Novelty: 0.05807454
p_int: 0.995217426
p_ni: 0.004782574
Score: 0.992
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (3)
Reactome (3)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Chromatin modifying enzymes | ||||
Reactome | Chromatin organization | ||||
Reactome | HATs acetylate histones | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Chromatin modifying enzymes | ||||
Chromatin organization | ||||
HATs acetylate histones | ||||
Viral Interactions (0)
Gene Ontology Terms (16)
Functions (7)
Components (3)
Processes (6)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Sequence Model (ISM) | NTNU_SB | |||
Traceable Author Statement (TAS) | ProtInc | |||
Traceable Author Statement (TAS) | ProtInc | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Disease Associations ()
GWAS Traits (20)
Items per page:
1 – 5 of 20
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
high density lipoprotein cholesterol measurement | 5 | 4 | 7 | 93.2 | |||||
eosinophil count | 2 | 1 | 2 | 79 | |||||
self reported educational attainment | 1 | 1 | 1 | 70.5 | |||||
alkaline phosphatase measurement | 2 | 1 | 1 | 7 | 64.4 | ||||
triglyceride measurement | 2 | 2 | 2 | 57.7 | |||||
Items per page:
1 – 5 of 20
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
high density lipoprotein cholesterol measurement | 7 | 93.2 | |||||
eosinophil count | 2 | 79 | |||||
self reported educational attainment | 1 | 70.5 | |||||
alkaline phosphatase measurement | 1 | 7 | 64.4 | ||||
triglyceride measurement | 2 | 57.7 | |||||
Find similar targets by:
IDG Resources
Orthologs (15)
1 – 5 of 15
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | down-regulator of transcription 1 | VGNC:11312 | 457031 | |||||
Mouse | MGI:1100515 | 13486 | ||||||
Rat | RGD:1305201 | 289881 | ||||||
Dog | down-regulator of transcription 1 | VGNC:40087 | 479943 | |||||
Horse | down-regulator of transcription 1 | VGNC:17308 | 100059248 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | down-regulator of transcription 1 | |||||
Mouse | ||||||
Rat | ||||||
Dog | down-regulator of transcription 1 | |||||
Horse | down-regulator of transcription 1 | |||||
Publication Statistics
PubMed Score 710.70
PubMed score by year
PubTator Score 650.07
PubTator score by year
Related Publications
Text Mined References (30)
GeneRif Annotations (11)
Items per page:
0 of 0
PMID | Year | Title |
---|