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Tbio
IL1RL1
Interleukin-1 receptor-like 1

Protein Summary
Description
Receptor for interleukin-33 (IL-33); signaling requires association of the coreceptor IL1RAP. Its stimulation recruits MYD88, IRAK1, IRAK4, and TRAF6, followed by phosphorylation of MAPK3/ERK1 and/or MAPK1/ERK2, MAPK14, and MAPK8. Possibly involved in helper T-cell function. Isoform B: Inhibits IL-33 signaling. The protein encoded by this gene is a member of the interleukin 1 receptor family. Studies of the similar gene in mouse suggested that this receptor can be induced by proinflammatory stimuli, and may be involved in the function of helper T cells. This gene, interleukin 1 receptor, type I (IL1R1), interleukin 1 receptor, type II (IL1R2) and interleukin 1 receptor-like 2 (IL1RL2) form a cytokine receptor gene cluster in a region mapped to chromosome 2q12. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000233954
  • ENSP00000233954
  • ENSG00000115602
  • ENST00000311734
  • ENSP00000310371
  • ENST00000404917
  • ENSP00000384822
  • ENST00000427077
  • ENSP00000391120

Symbol
  • DER4
  • ST2
  • T1
  • T1
  • ST2
  • DER4
  • ST2L
  • ST2V
  • FIT-1
  • IL33R
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.98
protein domain
0.97
disease
0.81
phenotype
0.75
kinase perturbation
0.66


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 191.88   (req: < 5)
Gene RIFs: 163   (req: <= 3)
Antibodies: 497   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 191.88   (req: >= 5)
Gene RIFs: 163   (req: > 3)
Antibodies: 497   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (36)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil count
6
9
8
6.4
99.7
17
14
1
1.2
99.3
serum ST2 measurement
1
8
8
99.1
eosinophil percentage of leukocytes
2
5
5
98.6
childhood onset asthma
3
5
0
1.2
98.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil count
8
6.4
99.7
1
1.2
99.3
serum ST2 measurement
8
99.1
eosinophil percentage of leukocytes
5
98.6
childhood onset asthma
0
1.2
98.6
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
interleukin 1 receptor like 1
711893
Mouse
MGI:98427
17082
Rat
RGD:2894
25556
Dog
interleukin 1 receptor like 1
VGNC:41961
611442
Horse
interleukin 1 receptor like 1
VGNC:19011
100058357
Species
Name
OMA
EggNOG
Inparanoid
Macaque
interleukin 1 receptor like 1
Mouse
Rat
Dog
interleukin 1 receptor like 1
Horse
interleukin 1 receptor like 1
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q01638-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (12)
Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
Immune System
Reactome
Interleukin-1 family signaling
Reactome
Interleukin-33 signaling
Reactome
Intracellular signaling by second messengers
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
Immune System
Interleukin-1 family signaling
Interleukin-33 signaling
Intracellular signaling by second messengers
Gene Ontology Terms (15)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
UniProtKB
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (66)
1 – 10 of 66
IL33
Tbio
Novelty:  0.00072064
Score:  0.999
Data Source:  Reactome,STRINGDB
MYD88
Tbio
Novelty:  0.00037931
Score:  0.968
Data Source:  Reactome,STRINGDB
IRAK1
Tchem
Family:  Kinase
Novelty:  0.00170873
Score:  0.957
Data Source:  Reactome,STRINGDB
IRAK4
Tchem
Family:  Kinase
Novelty:  0.00344058
Score:  0.957
Data Source:  Reactome,STRINGDB
TRAF6
Tbio
Novelty:  0.00109366
Score:  0.955
Data Source:  Reactome,STRINGDB
IL13
Tbio
Novelty:  0.00021435
Score:  0.931
Data Source:  STRINGDB
IL1RAP
Tclin
Novelty:  0.01115915
Score:  0.841
Data Source:  Reactome,STRINGDB
TMED1
Tbio
Novelty:  0.11862267
Score:  0.759
Data Source:  STRINGDB
IL4
Tbio
Novelty:  0.00005852
Score:  0.741
Data Source:  STRINGDB
GATA3
Tbio
Family:  TF
Novelty:  0.00071141
Score:  0.724
Data Source:  STRINGDB
Publication Statistics
PubMed Score  191.88

PubMed score by year
PubTator Score  2096.11

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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