Tbio IL1RL1 Interleukin-1 receptor-like 1

Protein Summary

Description

Receptor for interleukin-33 (IL-33); signaling requires association of the coreceptor IL1RAP. Its stimulation recruits MYD88, IRAK1, IRAK4, and TRAF6, followed by phosphorylation of MAPK3/ERK1 and/or MAPK1/ERK2, MAPK14, and MAPK8. Possibly involved in helper T-cell function. Isoform B: Inhibits IL-33 signaling. The protein encoded by this gene is a member of the interleukin 1 receptor family. Studies of the similar gene in mouse suggested that this receptor can be induced by proinflammatory stimuli, and may be involved in the function of helper T cells. This gene, interleukin 1 receptor, type I (IL1R1), interleukin 1 receptor, type II (IL1R2) and interleukin 1 receptor-like 2 (IL1RL2) form a cytokine receptor gene cluster in a region mapped to chromosome 2q12. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q01638
• A8K6B3
• B4E0I3
• Q53TU7
• Q8NEJ3
• Q9ULV7
• Q9UQ44

Gene Name

• IL1RL1

Ensembl ID

• ENST00000233954
• ENSP00000233954
• ENSG00000115602
• ENST00000311734
• ENSP00000310371
• ENST00000404917
• ENSP00000384822
• ENST00000427077
• ENSP00000391120

Symbol

• DER4
• ST2
• T1
• T1
• ST2
• DER4
• ST2L
• ST2V
• FIT-1
• IL33R

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
gene perturbation	0.98
protein domain	0.97
disease	0.81
phenotype	0.75
kinase perturbation	0.66

Protein Classes

PANTHER Classes

Protein / Receptor / Cytokine Receptor / Type I Cytokine Receptor / Interleukin-1 Receptor-like 1

DTO Classes

Protein / Receptor / Cytokine Receptor / Type I Cytokine Receptor / Interleukin-1 Receptor-like 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 243.18   (req: < 5)

Gene RIFs: 223   (req: <= 3)

Antibodies: 497   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 243.18   (req: >= 5)

Gene RIFs: 223   (req: > 3)

Antibodies: 497   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0