You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
IL1RL1
Interleukin-1 receptor-like 1

Protein Summary
Description
Receptor for interleukin-33 (IL-33); signaling requires association of the coreceptor IL1RAP. Its stimulation recruits MYD88, IRAK1, IRAK4, and TRAF6, followed by phosphorylation of MAPK3/ERK1 and/or MAPK1/ERK2, MAPK14, and MAPK8. Possibly involved in helper T-cell function. Isoform B: Inhibits IL-33 signaling. The protein encoded by this gene is a member of the interleukin 1 receptor family. Studies of the similar gene in mouse suggested that this receptor can be induced by proinflammatory stimuli, and may be involved in the function of helper T cells. This gene, interleukin 1 receptor, type I (IL1R1), interleukin 1 receptor, type II (IL1R2) and interleukin 1 receptor-like 2 (IL1RL2) form a cytokine receptor gene cluster in a region mapped to chromosome 2q12. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000233954
  • ENSP00000233954
  • ENSG00000115602
  • ENST00000311734
  • ENSP00000310371
  • ENST00000404917
  • ENSP00000384822
  • ENST00000427077
  • ENSP00000391120

Symbol
  • DER4
  • ST2
  • T1
  • T1
  • ST2
  • DER4
  • ST2L
  • ST2V
  • FIT-1
  • IL33R
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.98
protein domain
0.97
disease
0.81
phenotype
0.75
kinase perturbation
0.66


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 243.18   (req: < 5)
Gene RIFs: 219   (req: <= 3)
Antibodies: 497   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 243.18   (req: >= 5)
Gene RIFs: 219   (req: > 3)
Antibodies: 497   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0