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Tbio
IL1RL1
Interleukin-1 receptor-like 1

Protein Summary
Description
Receptor for interleukin-33 (IL-33); signaling requires association of the coreceptor IL1RAP. Its stimulation recruits MYD88, IRAK1, IRAK4, and TRAF6, followed by phosphorylation of MAPK3/ERK1 and/or MAPK1/ERK2, MAPK14, and MAPK8. Possibly involved in helper T-cell function. Isoform B: Inhibits IL-33 signaling. The protein encoded by this gene is a member of the interleukin 1 receptor family. Studies of the similar gene in mouse suggested that this receptor can be induced by proinflammatory stimuli, and may be involved in the function of helper T cells. This gene, interleukin 1 receptor, type I (IL1R1), interleukin 1 receptor, type II (IL1R2) and interleukin 1 receptor-like 2 (IL1RL2) form a cytokine receptor gene cluster in a region mapped to chromosome 2q12. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000233954
  • ENSP00000233954
  • ENSG00000115602
  • ENST00000311734
  • ENSP00000310371
  • ENST00000404917
  • ENSP00000384822
  • ENST00000427077
  • ENSP00000391120

Symbol
  • DER4
  • ST2
  • T1
  • T1
  • ST2
  • DER4
  • ST2L
  • ST2V
  • FIT-1
  • IL33R
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.98
protein domain
0.97
disease
0.81
phenotype
0.75
kinase perturbation
0.66


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 243.18   (req: < 5)
Gene RIFs: 163   (req: <= 3)
Antibodies: 497   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 243.18   (req: >= 5)
Gene RIFs: 163   (req: > 3)
Antibodies: 497   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (66)
IL33
Tbio
Novelty:  0.00072064
Score:  0.999
Data Source:  Reactome,STRINGDB
MYD88
Tbio
Novelty:  0.00037931
Score:  0.968
Data Source:  Reactome,STRINGDB
IRAK1
Tchem
Family:  Kinase
Novelty:  0.00170873
Score:  0.957
Data Source:  Reactome,STRINGDB
IRAK4
Tchem
Family:  Kinase
Novelty:  0.00344058
Score:  0.957
Data Source:  Reactome,STRINGDB
TRAF6
Tbio
Novelty:  0.00109366
Score:  0.955
Data Source:  Reactome,STRINGDB
IL13
Tclin
Novelty:  0.00021435
Score:  0.931
Data Source:  STRINGDB
IL1RAP
Tclin
Novelty:  0.01115915
Score:  0.841
Data Source:  Reactome,STRINGDB
TMED1
Tbio
Novelty:  0.11862267
Score:  0.759
Data Source:  STRINGDB
IL4
Tbio
Novelty:  0.00005852
Score:  0.741
Data Source:  STRINGDB
GATA3
Tbio
Family:  TF
Novelty:  0.00071141
Score:  0.724
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (12)
Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
Immune System
Reactome
Interleukin-1 family signaling
Reactome
Interleukin-33 signaling
Reactome
Intracellular signaling by second messengers
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
Immune System
Interleukin-1 family signaling
Interleukin-33 signaling
Intracellular signaling by second messengers
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (38)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
asthma
19
16
3
1.2
99.8
serum ST2 measurement
1
8
8
99.6
eosinophil count
8
10
10
6.4
99.6
allergic disease
7
6
4
1.1
99
childhood onset asthma
3
5
0
1.2
99
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
asthma
3
1.2
99.8
serum ST2 measurement
8
99.6
eosinophil count
10
6.4
99.6
allergic disease
4
1.1
99
childhood onset asthma
0
1.2
99
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
interleukin 1 receptor like 1
711893
Mouse
MGI:98427
17082
Rat
RGD:2894
25556
Dog
interleukin 1 receptor like 1
VGNC:41961
611442
Horse
interleukin 1 receptor like 1
VGNC:19011
100058357
Species
Name
OMA
EggNOG
Inparanoid
Macaque
interleukin 1 receptor like 1
Mouse
Rat
Dog
interleukin 1 receptor like 1
Horse
interleukin 1 receptor like 1
Publication Statistics
PubMed Score 243.18
PubMed score by year
PubTator Score 2096.11
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title