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Tchem
HMGCS1
Hydroxymethylglutaryl-CoA synthase, cytoplasmic

Protein Summary
Description
This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000325110
  • ENSP00000322706
  • ENSG00000112972
  • ENST00000433297
  • ENSP00000399402

Symbol
  • HMGCS
  • HMGCS
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.96
small molecule perturbation
0.95
disease perturbation
0.93
gene perturbation
0.93
protein domain
0.85


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 81.69   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 208   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 81.69   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 208   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 22
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Active Ligands (1)
1 – 1 of 1
L-659,699
chemical structure image
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
2
1
2
36.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
2
36.5
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
3-hydroxy-3-methylglutaryl-CoA synthase 1
VGNC:4035
461892
Macaque
3-hydroxy-3-methylglutaryl-CoA synthase 1
702553
Mouse
MGI:107592
208715
Rat
RGD:70970
29637
Dog
3-hydroxy-3-methylglutaryl-CoA synthase 1
479344
Species
Name
OMA
EggNOG
Inparanoid
Chimp
3-hydroxy-3-methylglutaryl-CoA synthase 1
Macaque
3-hydroxy-3-methylglutaryl-CoA synthase 1
Mouse
Rat
Dog
3-hydroxy-3-methylglutaryl-CoA synthase 1
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q01581-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (27)
Activation of gene expression by SREBF (SREBP) (R-HSA-2426168)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of gene expression by SREBF (SREBP)
Reactome
Cholesterol biosynthesis
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
Metabolism of steroids
Name
Explore in Pharos
Explore in Source
Activation of gene expression by SREBF (SREBP)
Cholesterol biosynthesis
Metabolism
Metabolism of lipids
Metabolism of steroids
Gene Ontology Terms (24)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (168)
1 – 10 of 168
CDK15
Tchem
Family: Kinase
Novelty: 0.3870338
p_int: 0.998945929
p_ni: 0.00105407
Data Source: BioPlex
IL17F
Tbio
Novelty: 0.00223549
p_int: 0.998571666
p_ni: 0.001426859
p_wrong: 0.000001475
Data Source: BioPlex
MBD5
Tbio
Family: Epigenetic
Novelty: 0.03015349
p_int: 0.998370519
p_ni: 0.001629472
p_wrong: 9e-9
Score: 0.169
Data Source: BioPlex,STRINGDB
SPANXB1
Tbio
Novelty: 0.19187624
p_int: 0.997034414
p_ni: 0.002963353
p_wrong: 0.000002233
Data Source: BioPlex
FAM24B
Tdark
Novelty: 1.04675689
p_int: 0.996195783
p_ni: 0.002693141
p_wrong: 0.001111076
Data Source: BioPlex
SDC1
Tbio
Novelty: 0.00044792
p_int: 0.995351117
p_ni: 0.004648866
p_wrong: 1.8e-8
Data Source: BioPlex
OR5F1
Tdark
Family: oGPCR
Novelty: 13
p_int: 0.988543713
p_ni: 0.011446564
p_wrong: 0.000009723
Score: 0.198
Data Source: BioPlex,STRINGDB
NFYA
Tbio
Family: TF
Novelty: 0.00507094
p_int: 0.988067329
p_ni: 0.011932671
Score: 0.956
Data Source: BioPlex,STRINGDB
FGB
Tbio
Novelty: 0.00437751
p_int: 0.968648715
p_ni: 0.031346878
p_wrong: 0.000004407
Score: 0.218
Data Source: BioPlex,STRINGDB
SLC22A5
Tbio
Family: Transporter
Novelty: 0.00290828
p_int: 0.958393039
p_ni: 0.041599653
p_wrong: 0.000007309
Score: 0.296
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  81.69

PubMed score by year
PubTator Score  14.93

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer