Tchem HMGCS1 Hydroxymethylglutaryl-CoA synthase, cytoplasmic

Protein Summary

Description

This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.

Uniprot Accession IDs

• Q01581
• B2RDL8
• HMG-CoA synthase

Gene Name

• HMGCS1

Ensembl ID

• ENST00000325110
• ENSP00000322706
• ENSG00000112972
• ENST00000433297
• ENSP00000399402

Symbol

• HMGCS
• HMGCS

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor perturbation	0.96
small molecule perturbation	0.95
disease perturbation	0.93
gene perturbation	0.93
protein domain	0.85

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 102.66   (req: < 5)

Gene RIFs: 18   (req: <= 3)

Antibodies: 208   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 102.66   (req: >= 5)

Gene RIFs: 18   (req: > 3)

Antibodies: 208   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 22

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0