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Tchem
HMGCS1
Hydroxymethylglutaryl-CoA synthase, cytoplasmic

Protein Summary
Description
This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000325110
  • ENSP00000322706
  • ENSG00000112972
  • ENST00000433297
  • ENSP00000399402

Symbol
  • HMGCS
  • HMGCS
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.96
small molecule perturbation
0.95
disease perturbation
0.93
gene perturbation
0.93
protein domain
0.85


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 47.58   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 208   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 47.58   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 208   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 22
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Active Ligands (1)
1 – 1 of 1
L-659,699
chemical structure image
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (27)
Activation of gene expression by SREBF (SREBP) (R-HSA-2426168)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of gene expression by SREBF (SREBP)
Reactome
Cholesterol biosynthesis
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
Metabolism of steroids
Name
Explore in Pharos
Explore in Source
Activation of gene expression by SREBF (SREBP)
Cholesterol biosynthesis
Metabolism
Metabolism of lipids
Metabolism of steroids
Gene Ontology Terms (24)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (168)
1 – 10 of 168
CDK15
Tchem
Family: Kinase
Novelty: 3.88235294
p_int: 0.998945929
p_ni: 0.00105407
Data Source: BioPlex
IL17F
Tbio
Novelty: 0.00311315
p_int: 0.998571666
p_ni: 0.001426859
p_wrong: 0.000001475
Data Source: BioPlex
MBD5
Tbio
Family: Epigenetic
Novelty: 0.03239638
p_int: 0.998370519
p_ni: 0.001629472
p_wrong: 9e-9
Score: 0.169
Data Source: BioPlex,STRINGDB
SPANXB1
Tbio
Novelty: 0.25954499
p_int: 0.997034414
p_ni: 0.002963353
p_wrong: 0.000002233
Data Source: BioPlex
FAM24B
Tdark
p_int: 0.996195783
p_ni: 0.002693141
p_wrong: 0.001111076
Data Source: BioPlex
SDC1
Tbio
Novelty: 0.0006457
p_int: 0.995351117
p_ni: 0.004648866
p_wrong: 1.8e-8
Data Source: BioPlex
OR5F1
Tdark
Family: oGPCR
p_int: 0.988543713
p_ni: 0.011446564
p_wrong: 0.000009723
Score: 0.198
Data Source: BioPlex,STRINGDB
NFYA
Tbio
Family: TF
Novelty: 0.00782217
p_int: 0.988067329
p_ni: 0.011932671
Score: 0.956
Data Source: BioPlex,STRINGDB
FGB
Tbio
Novelty: 0.00757235
p_int: 0.968648715
p_ni: 0.031346878
p_wrong: 0.000004407
Score: 0.218
Data Source: BioPlex,STRINGDB
SLC22A5
Tbio
Family: Transporter
Novelty: 0.00325441
p_int: 0.958393039
p_ni: 0.041599653
p_wrong: 0.000007309
Score: 0.296
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  47.58

PubMed score by year
PubTator Score  14.93

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer