FLI1
Friend leukemia integration 1 transcription factor
Protein Summary
Sequence-specific transcriptional activator (PubMed:24100448, PubMed:26316623, PubMed:28255014). Recognizes the DNA sequence 5'-C[CA]GGAAGT-3'. This gene encodes a transcription factor containing an ETS DNA-binding domain. The gene can undergo a t(11;22)(q24;q12) translocation with the Ewing sarcoma gene on chromosome 22, which results in a fusion gene that is present in the majority of Ewing sarcoma cases. An acute lymphoblastic leukemia-associated t(4;11)(q21;q23) translocation involving this gene has also been identified. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]
- ENST00000281428
- ENSP00000281428
- ENSG00000151702
- ENST00000344954
- ENSP00000339627
- ENST00000527786
- ENSP00000433488
- ENST00000534087
- ENSP00000432950
- EWSR2
- SIC-1
- BDPLT21
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
molecular function | 0.9 | ||
transcription factor | 0.8 | ||
PubMedID | 0.78 | ||
hub protein | 0.75 | ||
transcription factor binding site profile | 0.73 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 180.09 (req: < 5)
Gene RIFs: 157 (req: <= 3)
Antibodies: 628 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 180.09 (req: >= 5)
Gene RIFs: 157 (req: > 3)
Antibodies: 628 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 14
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0