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Tbio
FLI1
Friend leukemia integration 1 transcription factor

Protein Summary
Description
Sequence-specific transcriptional activator (PubMed:24100448, PubMed:26316623, PubMed:28255014). Recognizes the DNA sequence 5'-C[CA]GGAAGT-3'. This gene encodes a transcription factor containing an ETS DNA-binding domain. The gene can undergo a t(11;22)(q24;q12) translocation with the Ewing sarcoma gene on chromosome 22, which results in a fusion gene that is present in the majority of Ewing sarcoma cases. An acute lymphoblastic leukemia-associated t(4;11)(q21;q23) translocation involving this gene has also been identified. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000281428
  • ENSP00000281428
  • ENSG00000151702
  • ENST00000344954
  • ENSP00000339627
  • ENST00000527786
  • ENSP00000433488
  • ENST00000534087
  • ENSP00000432950

Symbol
  • EWSR2
  • SIC-1
  • BDPLT21
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.9
transcription factor
0.8
PubMedID
0.78
hub protein
0.75
transcription factor binding site profile
0.73


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 137.56   (req: < 5)
Gene RIFs: 118   (req: <= 3)
Antibodies: 628   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 137.56   (req: >= 5)
Gene RIFs: 118   (req: > 3)
Antibodies: 628   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (60)
CDH5
Tbio
Novelty:  0.00072649
Score:  0.921
Data Source:  STRINGDB
GATA1
Tbio
Family:  TF
Novelty:  0.00077901
Score:  0.801
Data Source:  STRINGDB
EWSR1
Tbio
Novelty:  0.00068411
Score:  0.785
Data Source:  STRINGDB
CDC14A
Tbio
Family:  Enzyme
Novelty:  0.00416647
Score:  0.743
Data Source:  STRINGDB
SRF
Tbio
Family:  TF
Novelty:  0.00088839
Score:  0.674
Data Source:  STRINGDB
CDC34
Tbio
Novelty:  0.00650407
Score:  0.672
Data Source:  STRINGDB
CDK1
Tchem
Family:  Kinase
Novelty:  0.00040776
Score:  0.671
Data Source:  STRINGDB
FBXW7
Tbio
Novelty:  0.00180856
Score:  0.663
Data Source:  STRINGDB
RUNX1
Tbio
Family:  TF
Novelty:  0.0085181
Score:  0.657
Data Source:  STRINGDB
PHGDH
Tchem
Family:  Enzyme
Novelty:  0.00047542
Score:  0.641
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (30)
Developmental Biology (R-HSA-1266738)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Developmental Biology
Reactome
Transcriptional regulation of granulopoiesis
Name
Explore in Pharos
Explore in Source
Developmental Biology
Transcriptional regulation of granulopoiesis
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (17)
Find Similar Targets
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Sequence Alignment (ISA)
NTNU_SB
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations ()
No disease associations found
GWAS Traits (24)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet crit
2
3
3
93.8
platelet count
2
3
3
93.6
3
2
0
1.1
85.1
lymphocyte count
3
2
3
79.5
eosinophil count
1
1
1
76.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet crit
3
93.8
platelet count
3
93.6
0
1.1
85.1
lymphocyte count
3
79.5
eosinophil count
1
76.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
Fli-1 proto-oncogene, ETS transcription factor
VGNC:11772
451659
Macaque
Fli-1 proto-oncogene, ETS transcription factor
714748
Mouse
MGI:95554
14247
Rat
RGD:1309837
315532
Dog
Fli-1 proto-oncogene, ETS transcription factor
VGNC:40898
489286
Species
Name
OMA
EggNOG
Inparanoid
Chimp
Fli-1 proto-oncogene, ETS transcription factor
Macaque
Fli-1 proto-oncogene, ETS transcription factor
Mouse
Rat
Dog
Fli-1 proto-oncogene, ETS transcription factor
Publication Statistics
PubMed Score 137.56
PubMed score by year
PubTator Score 522.99
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title