Tchem MYT1 Myelin transcription factor 1

Protein Summary

Description

Binds to the promoter region of genes encoding proteolipid proteins of the central nervous system. May play a role in the development of neurons and oligodendroglia in the CNS. May regulate a critical transition point in oligodendrocyte lineage development by modulating oligodendrocyte progenitor proliferation relative to terminal differentiation and up-regulation of myelin gene transcription. The protein encoded by this gene is a member of a family of neural specific, zinc finger-containing DNA-binding proteins. The protein binds to the promoter regions of proteolipid proteins of the central nervous system and plays a role in the developing nervous system. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q01538
• E1P5H0
• F5H7M8
• O94922
• Q7Z5W2
• Q9UPV2
• MyT1

Gene Name

• MYT1

Ensembl ID

• ENST00000328439
• ENSP00000327465
• ENSG00000196132
• ENST00000536311
• ENSP00000442412
• ENST00000613234
• ENSP00000477771
• ENSG00000276876
• ENST00000616648
• ENSP00000483021

Symbol

• KIAA0835
• KIAA1050
• MTF1
• MYTI
• PLPB1
• MTF1
• MYTI
• NZF2
• PLPB1
• ZC2H2C1
• ZC2HC4A
• C20orf36

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
co-expressed gene	0.95
cell type or tissue	0.77
gene perturbation	0.76
molecular function	0.7
transcription factor	0.56

Protein Classes

PANTHER Classes

Protein / Transcription Factor / Zinc Finger Transcription Factor / Myelin Transcription Factor 1

DTO Classes

Protein / Transcription Factor / Zinc Finger Transcription Factor / Myelin Transcription Factor 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 31.07   (req: < 5)

Gene RIFs: 13   (req: <= 3)

Antibodies: 278   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 31.07   (req: >= 5)

Gene RIFs: 13   (req: > 3)

Antibodies: 278   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1