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Tchem
MYT1
Myelin transcription factor 1

Protein Summary
Description
Binds to the promoter region of genes encoding proteolipid proteins of the central nervous system. May play a role in the development of neurons and oligodendroglia in the CNS. May regulate a critical transition point in oligodendrocyte lineage development by modulating oligodendrocyte progenitor proliferation relative to terminal differentiation and up-regulation of myelin gene transcription. The protein encoded by this gene is a member of a family of neural specific, zinc finger-containing DNA-binding proteins. The protein binds to the promoter regions of proteolipid proteins of the central nervous system and plays a role in the developing nervous system. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000328439
  • ENSP00000327465
  • ENSG00000196132
  • ENST00000536311
  • ENSP00000442412
  • ENST00000613234
  • ENSP00000477771
  • ENSG00000276876
  • ENST00000616648
  • ENSP00000483021

Symbol
  • KIAA0835
  • KIAA1050
  • MTF1
  • MYTI
  • PLPB1
  • MTF1
  • MYTI
  • NZF2
  • PLPB1
  • ZC2H2C1
  • ZC2HC4A
  • C20orf36
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
0.95
cell type or tissue
0.77
gene perturbation
0.76
molecular function
0.7
transcription factor
0.56


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 27.37   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 278   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 27.37   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 278   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Approved Drugs (1)
1 – 1 of 1
dasatinib
chemical structure image
Active Ligands (1)
1 – 1 of 1
CHEMBL49120
chemical structure image
GWAS Traits (10)
Items per page:
1 – 5 of 10
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
1.1
86
1
1
0
1.1
86
self reported educational attainment
1
1
1
57.8
self reported educational attainment
1
1
1
57.8
mathematical ability
1
1
1
52
Items per page:
1 – 5 of 10
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
86
0
1.1
86
self reported educational attainment
1
57.8
self reported educational attainment
1
57.8
mathematical ability
1
52
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
myelin transcription factor 1
719050
Mouse
MGI:1100535
17932
Rat
RGD:1304899
362291
Dog
myelin transcription factor 1
VGNC:43591
485987
Horse
myelin transcription factor 1
VGNC:20528
100051884
Species
Name
OMA
EggNOG
Inparanoid
Macaque
myelin transcription factor 1
Mouse
Rat
Dog
myelin transcription factor 1
Horse
myelin transcription factor 1
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q01538-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (4)
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
WikiPathways
Integrated Breast Cancer Pathway
WikiPathways
MECP2 and Associated Rett Syndrome
WikiPathways
G1 to S cell cycle control
WikiPathways
Oligodendrocyte Specification and differentiation(including remyelination), leading to Myelin Components for CNS
Name
Explore in Pharos
Explore in Source
Integrated Breast Cancer Pathway
MECP2 and Associated Rett Syndrome
G1 to S cell cycle control
Oligodendrocyte Specification and differentiation(including remyelination), leading to Myelin Components for CNS
Gene Ontology Terms (12)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence Alignment (ISA)
NTNU_SB
Non-traceable Author Statement (NAS)
UniProtKB
Non-traceable Author Statement (NAS)
UniProtKB
Protein-Protein Interactions (40)
1 – 10 of 40
CDK1
Tchem
Family: Kinase
Novelty: 0.00040776
Score: 0.975
Data Source: STRINGDB
PIN1
Tchem
Family: Enzyme
Novelty: 0.00957198
Score: 0.944
Data Source: STRINGDB
CCNB1
Tchem
Novelty: 0.0005503
Score: 0.94
Data Source: STRINGDB
RPS6KA1
Tchem
Family: Kinase
Novelty: 0.00178073
Score: 0.921
Data Source: STRINGDB
MAPK3
Tchem
Family: Kinase
Novelty: 0.00012969
Score: 0.904
Data Source: STRINGDB
MAPK1
Tchem
Family: Kinase
Novelty: 0.00061058
Score: 0.902
Data Source: STRINGDB
PI4KA
Tchem
Family: Kinase
Novelty: 0.01701469
Score: 0.9
Data Source: STRINGDB
PLP1
Tbio
Novelty: 0.00129083
Score: 0.779
Data Source: STRINGDB
PKMYT1
Tchem
Family: Kinase
Novelty: 0.03025516
Score: 0.758
Data Source: STRINGDB
ZFHX4
Tbio
Family: TF
Novelty: 0.06538087
Score: 0.675
Data Source: STRINGDB
Publication Statistics
PubMed Score  27.37

PubMed score by year
PubTator Score  50.81

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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