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Tbio
DEFA6
Defensin-6

Protein Summary
Description
Has very low antimicrobial activity against Gram-negative and Gram-positive bacteria. May protect cells against infection with HIV-1. Defensins are a family of antimicrobial and cytotoxic peptides thought to be involved in host defense. They are abundant in the granules of neutrophils and also found in the epithelia of mucosal surfaces such as those of the intestine, respiratory tract, urinary tract, and vagina. Members of the defensin family are highly similar in protein sequence and distinguished by a conserved cysteine motif. Several alpha defensin genes appear to be clustered on chromosome 8. The protein encoded by this gene, defensin, alpha 6, is highly expressed in the secretory granules of Paneth cells of the small intestine, and likely plays a role in host defense of human bowel. [provided by RefSeq, Oct 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000297436
  • ENSP00000297436
  • ENSG00000164822
  • ENST00000646187
  • ENSP00000494361
  • ENSG00000285136

Symbol
  • DEF6
  • DEF6
  • HD-6
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.58
phenotype
0.5
cell line
0.49
cellular component
0.42
PubMedID
0.42


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 30.52   (req: < 5)
Gene RIFs: 17   (req: <= 3)
Antibodies: 88   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 30.52   (req: >= 5)
Gene RIFs: 17   (req: > 3)
Antibodies: 88   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (20)
Items per page:
1 – 5 of 20
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte percentage of leukocytes
2
6
7
98.5
monocyte percentage of leukocytes
2
6
7
98.5
basophil percentage of leukocytes
2
8
8
97.9
basophil percentage of leukocytes
2
8
8
97.9
basophil count
2
7
8
97.7
Items per page:
1 – 5 of 20
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte percentage of leukocytes
7
98.5
monocyte percentage of leukocytes
7
98.5
basophil percentage of leukocytes
8
97.9
basophil percentage of leukocytes
8
97.9
basophil count
8
97.7
Protein Structure (2 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q01524-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (7)
Alpha-defensins (R-HSA-1462054)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Alpha-defensins
Reactome
Antimicrobial peptides
Reactome
Defensins
Reactome
Immune System
Reactome
Innate Immune System
Name
Explore in Pharos
Explore in Source
Alpha-defensins
Antimicrobial peptides
Defensins
Immune System
Innate Immune System
Gene Ontology Terms (14)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Protein-Protein Interactions (57)
1 – 10 of 57
ZFPM1
Tbio
Family:  TF
Novelty:  0.01061715
p_int:  0.999999895
p_ni:  1.03e-7
p_wrong:  2e-9
Score:  0.214
Data Source:  BioPlex,STRINGDB
POTEE
Tbio
Novelty:  0.29349205
p_int:  0.999999789
p_ni:  2.1e-7
Data Source:  BioPlex
VWA1
Tbio
Novelty:  0.00212445
p_int:  0.999982285
p_ni:  0.000017715
Score:  0.186
Data Source:  BioPlex,STRINGDB
PZP
Tbio
Novelty:  0.00670076
p_int:  0.999946482
p_ni:  0.000023534
p_wrong:  0.000029984
Score:  0.332
Data Source:  BioPlex,STRINGDB
IP6K1
Tbio
Family:  Kinase
Novelty:  0.03418032
p_int:  0.999922615
p_ni:  0.000077385
Score:  0.158
Data Source:  BioPlex,STRINGDB
RBPMS2
Tbio
Novelty:  0.14005113
p_int:  0.999768427
p_ni:  0.000231573
Score:  0.189
Data Source:  BioPlex,STRINGDB
ZFYVE9
Tbio
Novelty:  0.00565862
p_int:  0.999703496
p_ni:  0.000294478
p_wrong:  0.000002026
Score:  0.188
Data Source:  BioPlex,STRINGDB
EXTL3
Tbio
Family:  Enzyme
Novelty:  0.00714713
p_int:  0.996021286
p_ni:  0.003978714
Data Source:  BioPlex
FBXO11
Tbio
Novelty:  0.02762674
p_int:  0.993497673
p_ni:  0.006502327
Data Source:  BioPlex
YAP1
Tchem
Novelty:  0.00124225
p_int:  0.979358508
p_ni:  0.020641488
p_wrong:  4e-9
Score:  0.177
Data Source:  BioPlex,STRINGDB
Publication Statistics
PubMed Score  30.52

PubMed score by year
PubTator Score  57.1

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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