You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
DEFA5
Defensin-5

Protein Summary
Description
Has antimicrobial activity against Gram-negative and Gram-positive bacteria. Defensins are thought to kill microbes by permeabilizing their plasma membrane. All DEFA5 peptides exert antimicrobial activities, but their potency is affected by peptide processing. Defensins are a family of antimicrobial and cytotoxic peptides thought to be involved in host defense. They are abundant in the granules of neutrophils and also found in the epithelia of mucosal surfaces such as those of the intestine, respiratory tract, urinary tract, and vagina. Members of the defensin family are highly similar in protein sequence and distinguished by a conserved cysteine motif. Several of the alpha defensin genes appear to be clustered on chromosome 8. The protein encoded by this gene, defensin, alpha 5, is highly expressed in the secretory granules of Paneth cells of the ileum. [provided by RefSeq, Oct 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000330590
  • ENSP00000329890
  • ENSG00000164816
  • ENST00000647159
  • ENSP00000494799
  • ENSG00000285251

Symbol
  • DEF5
  • DEF5
  • HD-5
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.93
biological term
0.63
cellular component
0.59
protein domain
0.58
phenotype
0.57


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 127.84   (req: < 5)
Gene RIFs: 54   (req: <= 3)
Antibodies: 232   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 127.84   (req: >= 5)
Gene RIFs: 54   (req: > 3)
Antibodies: 232   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (121)
ARHGAP19
Tbio
Family:  Enzyme
Novelty:  0.19587262
p_int:  0.999999998
p_ni:  1e-9
Data Source:  BioPlex
SHLD2
Tbio
Novelty:  0.55336226
p_int:  0.99999881
p_ni:  9.3e-8
p_wrong:  0.000001097
Score:  0.187
Data Source:  BioPlex,STRINGDB
WAPL
Tbio
Novelty:  0.01598061
p_int:  0.999998019
p_ni:  0.000001981
Data Source:  BioPlex
SUSD5
Tdark
Novelty:  1.0992718
p_int:  0.999993115
p_ni:  0.000006885
Data Source:  BioPlex
HSPA14
Tbio
Novelty:  0.01714625
p_int:  0.99999262
p_ni:  0.00000738
Data Source:  BioPlex
CILP2
Tbio
Novelty:  0.07992715
p_int:  0.999988924
p_ni:  3.53e-7
p_wrong:  0.000010723
Data Source:  BioPlex
GLCE
Tbio
Family:  Enzyme
Novelty:  0.0497423
p_int:  0.999984485
p_ni:  0.000015514
p_wrong:  1e-9
Data Source:  BioPlex
IP6K1
Tbio
Family:  Kinase
Novelty:  0.03418032
p_int:  0.999974782
p_ni:  0.000025218
Data Source:  BioPlex
ZBTB33
Tbio
Family:  TF
Novelty:  0.01327474
p_int:  0.99994452
p_ni:  0.00005548
Data Source:  BioPlex
CEP170B
Tdark
Novelty:  0.30498676
p_int:  0.999928311
p_ni:  0.000066615
p_wrong:  0.000005074
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (7)
Alpha-defensins (R-HSA-1462054)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Alpha-defensins
Reactome
Antimicrobial peptides
Reactome
Defensins
Reactome
Immune System
Reactome
Innate Immune System
Name
Explore in Pharos
Explore in Source
Alpha-defensins
Antimicrobial peptides
Defensins
Immune System
Innate Immune System
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (20)
Items per page:
1 – 5 of 20
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte percentage of leukocytes
2
6
7
98.4
monocyte percentage of leukocytes
2
6
7
98.4
basophil count
3
8
10
98.3
basophil count
3
8
10
98.3
basophil percentage of leukocytes
2
7
7
97.8
Items per page:
1 – 5 of 20
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte percentage of leukocytes
7
98.4
monocyte percentage of leukocytes
7
98.4
basophil count
10
98.3
basophil count
10
98.3
basophil percentage of leukocytes
7
97.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Publication Statistics
PubMed Score 127.84
PubMed score by year
PubTator Score 116.67
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title